Data processing, analysis method of gene expression data to identify endogenous reference genes

ABSTRACT

Disclosed are data processing and analysis methods for gene expression data for identifying endogenous reference genes and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in amplifying the identified endogenous reference genes. Introduced with the concepts of “Zero&#39;s proportion” and CV, the method allows different datasets to be integrally analyzed, thereby searching for novel reference genes. By the method, 2,087 genes are first found as housekeeping genes which are expressed in most tissues, and the usefulness thereof in the relative quantification of different target genes is determined by analyzing their expression stability. Of the 2,087 genes, 13 genes show higher expression stability with lower expression levels across a wide range of samples than traditional reference genes such as GAPDH and ACTS, and therefore are suitable for the normalization of universal genes having relatively low expression levels.

RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.13/631,279 filed on Sep. 28, 2012 and U.S. application Ser. No.12/521,498, filed on Jun. 26, 2009, which is the U.S. national phasepursuant to 35 U.S.C. § 371, of PCT international application Ser. No.PCT/KR2007/006890, filed Dec. 27, 2007, designating the United Statesand published in English on Jul. 3, 2008 as publication WO 2008/078969A1, which claims priority to Korean application Ser. No.10-2006-0134883, filed Dec. 27, 2006. The entire contents of theaforementioned patent applications are incorporated herein by thisreference.

SEQUENCE LISTING

The instant application contains a Sequence Listing which has beensubmitted in ASCII format via EFS-Web and is hereby incorporated byreference in its entirety. Said ASCII copy, created on May 24, 2013, isnamed 84346-CON-301519_ST25.txt and is 8,058 bytes in size.

TECHNICAL FIELD

The present invention relates to a data processing and analysis methodof gene expression data for identifying endogenous reference genes and acomposition for the quantitative analysis of gene expression, comprisinga pair of primers and/or probes useful in the amplification of theidentified endogenous reference genes. More particularly, the presentinvention relates to a data processing and analysis method foridentifying novel endogenous reference genes using gene expression datafrom EST, SAGE and microarray datasets with zero's proportion andcoefficient of variation, and a composition for the quantitativeanalysis of gene expression, comprising a pair of primers and/or probesuseful in the amplification of the identified endogenous referencegenes.

BACKGROUND ART

As many as 50,000-100,000 genes can be found in each human cell, but areselectively used in each cell. Of them, a significant number of genesare involved in basic functions and routine cellular metabolic processesrequired for the sustenance of the cell. Such genes are calledhousekeeping genes (hereinafter referred to as “HKG”). In various geneexpression analysis methods utilizing the quantification of messengerRNA (hereinafter referred to as “mRNA”) to determine expression levelsof specific or multiple genes with the aim of identifying the functionsof specific genes, searching for genes directed to specific functions,profiling the gene expression of organisms under specific conditions,and describing other biological purposes, endogenous reference genesmean housekeeping genes useful in the normalization of the mRNA levelfor the relative quantification of genes of interest.

Endogenous reference genes are most widely used to normalize mRNA levelfor accurate comparison of gene expression between different samples(Vandesompele J et al., Genome Biol 3(7), p. RESEARCH0034, 2002).Endogenous reference genes are usually used in gene expression analysistechniques ranging from conventional reverse transcriptase polymerasechain reaction (hereinafter referred to as “RT-PCR”) to recentlydeveloped quantitative real time PCR (hereinafter referred to as“qRT-PCT”), serial analysis of gene expression (hereinafter referred toas “SAGE”) and microarray. Traditional reference genes such asglyceraldehyde-3-phosphate dehydrogenase (hereinafter referred to as“GAPDH”) and β-actin (hereinafter referred to as “ACTB”) have been usedwithout proper validation, assuming that they are expressed at constantlevels across different samples, irrespectively cell or tissue type andare not regulated by experimental treatment.

However, it is well known that the expression of traditional referencegenes may vary among different tissues and cell types and can beregulated by experimental conditions, including sample treatment,developmental stage and pathological states (Bereta J and Bereta M,Biochem Biophys Res Commun 217(1)363-369, 1995; Tricarico C et al., AnalBiochem 309(2):293-300, 2002; Thellin O et al., J Biotechnol75(2-3):291-295, 1999; Rubie C et al., Mol Cell Probes 19(2):101-109,2005; Schmittgen T D and Zakrajsek B A, J Biochem Biophys Methods46(1-2):69-81, 2000; Zhong H and JSimons W, Biochem Biophys Res Commun259(3):523-526, 1999; Selvey S et al., Mol Cell Probes 15(5):307-311,2001; Wu Y Y and LRees J, Acta Derm Venereol 80(1):2-3, 2000; Lee P D etal., Genome Res 12(2):292-297, 2002; Hamalainen H K et al., Anal Biochem299(1):63-70, 2001). The use of inappropriate reference genes in therelative quantification of gene expression may result in biasedexpression profiles. This concern has already been raised by manyresearchers (Tricarico C et al., Anal Biochem 309(2):293-300 2002; DhedaK et al., Anal Biochem 344(1):141-143, 2005; de Kok J B et al., LabInvest 85(1):154-159, 2005; Brunner A M et al., BMC Plant Biol 4:14,2004). Particularly, the selection of proper endogenous reference genesis essential for accurate measurement in qRT-PCR, which is a reliablemethod for detecting gene expression with high sensitivity and accuracythough accurate normalization, and may not be required in qualitativeanalysis such as northern blot or conventional RT-PCR (Huggett J et al.,Genes Immun 6(4):279-284, 2005).

With the acknowledgement of the importance of the proper validation oftraditional reference genes and the identification of more suitablereference genes, a number of studies have been undertaken to select themost suitable genes among commonly used reference genes in specificexperimental conditions, or to identify novel genes, which are superiorto the traditional genes that are universally used for mRNAquantification. However, most of the previous studies have been focusedon the selection (validation) of the most stable genes among commonlyused reference genes in specific experimental systems or a given set oflimited tissue samples (Goidin D et al., Anal Biochem 295(1):17-21,2001; Haller F et al., Anal Biochem 335(1):1-9, 2004; Ohl F et al., JMol Med 83(12):1014-1024, 2005; Radonic A et al., Biochem Biophys ResCommun 313(4):856-862, 2004). Some programs are now available foridentifying the most appropriate genes among multiple reference genesusing qRT-PCR results (Vandesompele J et al., Genome Biol 3(7), p.RESEARCH0034, 2002; Pfaffl M W et al., Biotechnol Lett 26(6):509-15,2004; Andersen C L et al., Cancer Res 64(15):5245-5250, 2004).

In addition, novel endogenous reference genes have been found mostly onthe basis of microarray data (Hamalainen H K et al., Anal Biochem299(1):63-70, 2001; Hoerndli F J et al., Anal Biochem 335(1):30-41,2004; Czechowski T et al., Plant Physiol 139(1):5-17, 2005; Jin P etal., BMC Genomics, 5(1):55, 2004; Kobayashi M S et al., J. Neurosci Res76(4):512-518, 2004; Shulzhenko N et al., Biochem Biophys Res Commun337(1):306-12, 2005). As is well-known, the microarray technique hassome problems and limitations (errors) due to the potential forinaccurate cross hybridization between probes and unintendedtranscripts, the potential for differences in hybridization efficiencybetween probe sets, and the potential for the incorrect annotation oftranscripts (Haverty P M et al., Bioinformatics 20(18):3431-3441, 2004;van Ruissen F et al., BMC Genomics 6:91, 2005). The microarray techniquealso allows the detection of expression of genes only on the chip, incontrast to expressed sequence tag (hereinafter referred to as “EST”)and SAGE, in which the expression profiles of whole transcripts insamples (cDNA libraries) can be measured (van Ruissen F et al., BMCGenomics 6:91, 2005). The use of gene expression data from differentplatforms together is expected to complement the limitation ofindividual platforms. For example, SAGE is far more sensitive than ESTfor detecting low-abundance transcripts (Sun M et al., BMC Genomics5(1):1-4, 2004).

Even if an ideal endogenous reference gene does not exist, it ispossible to find a more ideal endogenous reference gene applicable tomost experimental conditions than traditional reference genes throughvarious, large gene expression data.

Leading to the present invention, intensive and thorough research onaccurate comparison of gene expression among different samples,conducted by the present inventors, resulted in the finding that geneexpression datasets constructed from microarray data, in addition to ESTand SAGE data, are useful in searching for endogenous reference genes,and that novel reference genes identified using the datasets aresuperior to previously used genes and show more stable expression acrossa wide range of samples, thus being universally useful for thenormalization of gene expression, rather than being limited for use onspecific tissue samples or in specific studies.

DISCLOSURE Technical Problem

Therefore, it is an object of the present invention to provide a methodof processing and analyzing gene expression data, with a statisticalconcept introduced thereinto, to identify endogenous reference geneswhich are superior to traditional reference genes in terms of expressionstability across a wide range of samples, thus being universally usefulfor the normalization of gene expression, and a composition for thequantitative analysis of gene expression, comprising a pair of primersand/or probes useful in the amplification of the identified endogenousreference genes.

Technical Solution

In order to accomplish the above objects, the present invention providesa method for selecting candidate endogenous reference genes (ERG),comprising: 1) computing expression levels of genes from EST, SAGE andmicroarray datasets; and 2) identifying genes which are constitutivelyexpressed across a wide range of tissues using the computed geneexpression levels of step 1) and zero (0)'s proportions thereof.

Also, the present invention provides a composition for detecting atleast one candidate endogenous reference gene selected according to thepresent invention, comprising a detection reagent applicable toamplification of the candidate endogenous reference gene.

Also, there is provided a method for quantifying an expression level ofa gene of interest, comprising: 1) performing real-time PCR to amplifythe gene of interest with a pair of primers and/or probes and thenperforming real-time PCR to amplify the a candidate endogenous referencegene with the composition; and 2) normalizing the expression level ofthe gene of interest relative to that of the candidate endogenousreference gene.

Furthermore, there is provided a method for selecting guide genes,comprising: measuring the candidate endogenous reference genes selectedusing the method for coefficient of variation (CV); and ranking theendogenous reference genes in an ascending order of CV.

Also, the present invention provides a composition for detecting atleast one guide reference gene identified according to the presentinvention, comprising a detection reagent applicable to amplification ofthe guide gene.

There is provided a method for quantifying an expression level of atarget gene, comprising: 1) synthesizing cDNA from RNA of a subject; 2)performing real-time PCR to amplify the target gene using a pair ofprimers and/or probes, with the cDNA serving as a template and thenperforming real-time PCR to amplify the candidate endogenous referencegene using the composition; and 3) normalizing an expression level ofthe target gene to that of the candidate endogenous reference gene ofstep 2).

Moreover, there is provided a method for identifying the amplificationof a target gene in genomic DNA, comprising: 1) amplifying the targetgene with a pair of primers or probes through real-time PCR, with agenomic DNA of a subject serving as a template and then performingreal-time PCR to amplify the candidate endogenous reference gene withthe composition; and 2) normalizing an expression level of the targetgene to that of the candidate endogenous reference gene.

Advantageous Effects

Introduced with the concepts of ‘Zero's proportion’ and CV, the methodof the present invention allows different datasets to be integrallyanalyzed, thereby searching for novel reference genes. By the method,2,087 genes were first found as housekeeping genes which are expressedin most tissues, and the usefulness thereof in the relativequantification of different target genes was determined by analyzingtheir expression stability. Out of the 2,087 genes, 13 genes were foundto show higher expression stability with lower expression levels acrossa wide range of samples than traditional reference genes such as GAPDHand ACTB, and therefore are suitable for the normalization of universalgenes having relatively low expression levels.

DESCRIPTION OF DRAWINGS

FIG. 1 is a schematic view showing a process of identifying endogenousreference genes (ERGs).

FIG. 2 is a graph showing a functional distribution of candidate ERGsclassified according to FunCat (Functional Classification Catalogue):

Numeral: numbers of genes

A: protein fate (folding, modification, destination); B: cellulartransport, transport facilitation and transport route; C: transcription;D: cellular communication/signal transduction mechanism; E: cell cycleand DNA processing; F: protein synthesis; G: metabolism; H: energy; I:cell fate; J: interaction with cellular environment; K: interaction withenvironment (systemic); L: organ differentiation; M: development(systemic); N: protein activity regulation; 0: tissue differentiation;P: Biogenesis of cellular components; Q: cell rescue, defense andvirulence; and R: cell type differentiation.

FIG. 3 shows correlations of gene expression of 2,087 candidates ERGamong four datasets [EST (expressed sequence tag), ShortSAGE, LongSAGEand microarray datasets].

FIG. 4 shows correlations of CV (coefficient of variation %) of 2,087candidates ERGs among four datasets (EST, ShortSAGE, LongSAGE andmicroarray datasets).

FIG. 5 is a graph showing the comparison of gene expression between thecandidate ERGs, selected according to the present invention, andnon-candidate ERGs among each dataset:

Box and Whisker plots: expression distribution expressed as natural logvalue (1n);

Bottom surface of box: corresponding to 25% of the total expressionlevels in ascending order; and

Top surface of box: corresponding to 75% of the total expression levelsin ascending order.

FIG. 6 shows the comparison of gene expression between the 13 ERGs ofthe present invention and 13 arbitrarily selected traditional ERGs.

FIG. 7 shows the comparison of CV (%) between the 13 ERGs of the presentinvention and 13 arbitrarily selected traditional ERGs.

FIG. 8 is a graph showing mRNA level distributions of the novel andtraditional ERGs, determined by real-time PCR, in 48 samples includingfrozen human tissues and cancer cell lines.

FIG. 9 shows mRNA level distributions, expressed as Cp values determinedusing real-time PCR, of the novel and traditional ERGs in 48 samples(including frozen human tissues and cancer cell lines) and 60 FFPE(formalin-fixed paraffin-embedded) tissues. In the boxes, the middlelines represent median values of Cp, and the bottom and the top surfacescorrespond to 25% and 75% of the total Cp values in ascending order,respectively.

BEST MODE

The terms used herein are defined before embodiments of the presentinvention are described in detail.

The term “candidate reference gene”, as used herein, is intended torefer to a gene, selected using the method of the present invention,which shows a housekeeping gene (HKG)'s properties of beingconstitutively expressed across a wide range of tissues.

The term “guide gene”, as used herein, is intended to refer to a gene,selected from among candidate reference genes, which shows as low anexpression level and variation in expression level as most transcriptswithin cells, which is also expressed as “reference gene” or “endogenousreference gene”.

In accordance with an aspect thereof, the present invention provides amethod for selecting candidate endogenous reference genes (ERG),comprising:

1) computing expression levels of genes from EST, SAGE and microarraydatasets; and

2) identifying genes which are constitutively expressed across a widerange of tissues using the computed gene expression levels of step 1)and zero (0)'s proportions thereof.

Endogenous reference genes (ERG) are most widely used to normalize mRNAlevels for an accurate comparison of gene expression between differentsamples. ERG is usually applied to gene expression analysis, such asRT-PCR (reverse transcriptase polymerase chain reaction), qRT-PCR(quantitative real time PCR), SAGE (serial analysis of gene expression)and microarray. Traditional reference genes, such asglyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB),have been used without proper validation, assuming that they areexpressed at constant levels across different samples irrespectively thevarious origins thereof, and are not regulated according to experimentalconditions. However, it is well known that the expression of traditionalreference genes may differ from one tissue or cell type to another andcan be regulated by experimental conditions, including sample treatment,developmental stage and pathological states.

In order to search for candidate housekeeping genes (HKG) whoseexpression is maintained on similar levels in most tissues, first,datasets were constructed using EST and SAGE human gene expression datacollected from the publicly available CGAP site (The Cancer GenomeProject, http://cgap.nci.nih.gov/) and microarray gene expression dataobtained from the GeneExpress Oncology Datasuite™ of Gene Logic Inc.,based on the Affymetrix Human Genome U133 array set. Although theabove-mentioned databases were combined to construct new datasets, itshould be noted that availability is not limited to the databases. Usingthe expression data from the datasets, the expression level of a givengene is determined according to the following Mathematical Formulas 1and 2. The EST (expressed sequence tag) expression levels and the SAGEexpression levels of a gene in a given library can be calculatedaccording to Mathematical Formulas 1 and 2, respectively

$\begin{matrix}{{{ETS}\mspace{14mu} {gene}\mspace{14mu} {expression}} = {\frac{\begin{matrix}{{No}\mspace{14mu} {of}\mspace{14mu} {EST}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}} \\{{Gene}\mspace{14mu} {in}\mspace{14mu} {Library}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {ESTs}\mspace{14mu} {in}\mspace{14mu} {Library}} \times 1\text{,}000\text{,}000}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 1} >} \\{{{Sage}\mspace{14mu} {gene}\mspace{14mu} {expression}} = {\frac{\begin{matrix}{{No}\mspace{14mu} {of}\mspace{14mu} {Tags}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}} \\{{Gene}\mspace{14mu} {in}\mspace{14mu} {Library}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {Tags}\mspace{14mu} {in}\mspace{14mu} {Library}} \times 1\text{,}000\text{,}000}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 2} >}\end{matrix}$

In accordance with the present invention, data from the differentdatabases were analyzed to determine their integrity and to identifycommonality therebetween. In this regard, the concept of zero (0)'sproportion is introduced to determine the possibility that a given genemight be a housekeeping gene (HKG), which is ubiquitously expressedacross most tissues.

$\begin{matrix}{{{0'}s\mspace{14mu} {Proportion}} = \frac{\begin{matrix}{{{No}.\mspace{14mu} {of}}\mspace{14mu} {Tissues}\mspace{14mu} {with}\mspace{14mu} {No}} \\{{Expression}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}\mspace{14mu} {Gene}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {Tissues}}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 3} >}\end{matrix}$

As expressed by Mathematical Formula 3, zero (0)'s proportion is definedas the ratio of the number of the tissues with no expression of a givengene to the total number of tissues. The lower the 0's proportion is,the higher is the possibility that the given gene might be an HKG.Utilizing the concept of 0's proportion, genes which have low 0'sproportions in EST, ShortSAGE, and LongSAGE datasets were sorted. 2,087genes common to the 3 datasets were selected and categorized as“candidate reference genes” or “candidate ERGs”. The genes which havelow 0's proportions refer to genes with 0's proportions less than 0.4for EST, 0.1 for ShortSAGE, and 0.3 for LongSAGE. The mean geneexpression values and CV (%) of the 2,087 candidate reference genes werecalculated using another dataset, Affymetrix HG-U133, as well as in ESTand SAGE datasets. The expression data of 1,990 UniGene clusters (geneexpression data for 5,238 different probe sets, 5317 fragments)corresponding to 2,087 ERGs were obtained.

As a result, a significant correlation of the mean expression values isobserved among all of the four datasets (EST (expressed sequence tag),ShortSAGE, LongSAGE and microarray dataset)) (see FIG. 3). Correlationanalysis on CV showed lower agreement between datasets than on the meangene expression levels, although a significant correlation was detected(see FIG. 4).

In addition, the candidate ERGs were compared with non-ERGs with regardto gene expression in each dataset. As we expected, the mean geneexpression level of the candidate ERGs was significantly higher thanthat of non-ERGs in all of the four datasets (p<0.0001) (see FIG. 5).

In accordance with another aspect thereof, the present inventionprovides a composition for detecting at least one candidate endogenousreference gene selected according to the present invention, comprising adetection reagent applicable to amplification of the candidateendogenous reference gene.

The candidate endogenous reference gene useful in the present inventionis one or more genes selected from a group consisting of Accession No.Hs 120(PRDX6), Accession No. Hs 142(SULT1A1), Accession No. Hs202(BZRP), Accession No. Hs 429(ATP5G3), Accession No. Hs 695(CSTB),Accession No. Hs 808(HNRPF), Accession No. Hs 861(MAPK3), Accession No.Hs 1063(SNRPC), Accession No. Hs 1103(TGFB1), Accession No. Hs2430(TCFL1), Accession No. Hs 2533(ALDH9A1), Accession No. Hs2795(LDHA), Accession No. Hs 2853(PCBP1), Accession No. Hs 3100(KARS),Accession No. Hs 3254(MRPL23), Accession No. Hs 3353(G3BP), AccessionNo. Hs 3416(ADFP), Accession No. Hs 439(STOML2), Accession No. Hs3530(FUSIP1), Accession No. Hs 3989(PLXNB2), Accession No. Hs4055(KLF6), Accession No. Hs 4742(GPAA1), Accession No. Hs 4747(DKC1),Accession No. Hs 4766(FAM32A), Accession No. Hs 4859(CCNL1), AccessionNo. Hs 4997(RBM23), Accession No. Hs 4998(TMOD3), Accession No. Hs5062(TM4SF8), Accession No. Hs 5086(MGC10433), Accession No. Hs5120(DNCL1), Accession No. Hs 5158(ILK), Accession No. Hs5245(FLJ20643), Accession No. Hs 5258(MAGED1), Accession No. Hs5268(ZDHHC4), Accession No. Hs 5298(ADIPOR1), Accession No. Hs5308(UBA52), Accession No. Hs 5324(C2orf25), Accession No. Hs5345(RNPEPL1), Accession No. Hs 5662(GNB2L1), Accession No. Hs5710(CREG1), Accession No. Hs 5719(CNAP1), Accession No. Hs 5912(FBXO7),Accession No. Hs 5947(RAB8A), Accession No. Hs 6396(JTB), Accession No.Hs 6454(RGS19IP1), Accession No. Hs 6459(GPR172A), Accession No. Hs6551(ATP6AP1), Accession No. Hs 6891(SFRS6), Accession No. Hs7101(ANAPCS), Accession No. Hs 7236(NOSIP), Accession No. Hs7476(ATP6V0B), Accession No. Hs 7527(DKFZP566E144), Accession No. Hs7744(NDUFV1), Accession No. Hs 7753(CALU), Accession No. Hs 7768(FIBP),Accession No. Hs 7862(PNRC2), Accession No. Hs 7910(RYBP), Accession No.Hs 7917(HIG1), Accession No. Hs 8102(RPS20), Accession No. Hs8372(UQCR), Accession No. Hs 8737(WDR6), Accession No. Hs 8752(TMEM4),Accession No. Hs 8765(DDX42), Accession No. Hs 8859(CANT1), AccessionNo. Hs 8867(CYR61), Accession No. Hs 9003(FLJ13868), Accession No. Hs9015(MGC52000), Accession No. Hs 9043(C14orf120), Accession No. Hs9234(NIFIE14), Accession No. Hs 9235(NME4), Accession No. Hs9527(C2orf28), Accession No. Hs 9534(SEC11L1), Accession No. Hs9573(ABCF1), Accession No. Hs 9589(UBQLN1), Accession No. Hs9788(NDFIP1), Accession No. Hs 9825(CGI-128), Accession No. Hs9857(DCXR), Accession No. Hs 10326(COPE), Accession No. Hs 10842(RAN),Accession No. Hs 10848(BMS1L), Accession No. Hs 11125(SPCS1), AccessionNo. Hs 11184(UBE2R2), Accession No. Hs 11223(IDH1), Accession No. Hs11355(TMPO), Accession No. Hs 11463(UMP-CMPK), Accession No. Hs12013(ABCE1), Accession No. Hs 12084(TUFM), Accession No. Hs12102(SNX3), Accession No. Hs 12107(BC-2), Accession No. Hs12109(WDR39), Accession No. Hs 12144(KIAA1033), Accession No. Hs12152(SRPRB), Accession No. Hs 12272(BECN1), Accession No. Hs12341(ADAR), Accession No. Hs 12457(NUP133), Accession No. Hs12865(NSFL1C), Accession No. Hs 13662(MGC5508), Accession No. Hs14317(NOLA3), Accession No. Hs 14333(FLJ10349), Accession No. Hs14745(C10orf9), Accession No. Hs 14839(POLR2G), Accession No. Hs14846(SLC7A1), Accession No. Hs 14894(TGOLN2), Accession No. Hs15277(C16orf33), Accession No. Hs 15591(COPS6), Accession No. Hs15738(RAB7), Accession No. Hs 16059(HSPC009), Accession No. Hs16130(E2-230K), Accession No. Hs 16349(KIAA0431), Accession No. Hs17118(FLJ11730), Accession No. Hs 17250(MGC4767), Accession No. Hs17680(FUCA2), Accession No. Hs 17731(FLJ12892), Accession No. Hs17883(PPM1G), Accession No. Hs 18069(LGMN), Accession No. Hs18128(C20orf44), Accession No. Hs 18349(MRPL15), Accession No. Hs19673(MAF1), Accession No. Hs 20013(P29), Accession No. Hs 20107(KNS2),Accession No. Hs 20157(CDK5RAP3), Accession No. Hs 20521(HRMT1L2),Accession No. Hs 20529(LOC127262), Accession No. Hs 20573(IGF1R),Accession No. Hs 20716(TIMM17A), Accession No. Hs 22393(DENR), AccessionNo. Hs 22543(UBE3A), Accession No. Hs 22546(CYBASC3), Accession No. Hs22616(KIAA0664), Accession No. Hs 23033(LOC92912), Accession No. Hs23111(FARSLA), Accession No. Hs 23978(SAFB), Accession No. Hs24301(POLR2E), Accession No. Hs 24379(TRAPPC1), Accession No. Hs24601(FBLN1), Accession No. Hs 24950(RGSS), Accession No. Hs25155(NET1), Accession No. Hs 25450(SLC29A1), Accession No. Hs25723(MTVR1), Accession No. Hs 26010(PFKP), Accession No. Hs26023(FOXJ3), Accession No. Hs 26136(MGC14156), Accession No. Hs26232(MAN2C1), Accession No. Hs 26403(GSTZ1), Accession No. Hs26518(TM4SF7), Accession No. Hs 27222(NOLA2), Accession No. Hs28491(SAT), Accession No. Hs 28914(APRT), Accession No. Hs 29203(GBL),Accession No. Hs 29665(CLSTN1), Accession No. Hs 30011(MGC2963),Accession No. Hs 30026(HSPC182), Accession No. Hs 30345(TRAP1),Accession No. Hs 30954(PMVK), Accession No. Hs 31053(CKAP1), AccessionNo. Hs 31334(C20orf14), Accession No. Hs 31387(DKFZP564J0123), AccessionNo. Hs 34045(CDCA4), Accession No. Hs 34576(TAX1BP1), Accession No. Hs34906(BLOC1S2), Accession No. Hs 35052(TEGT), Accession No. Hs35828(MARK3), Accession No. Hs 36587(PPP1R7), Accession No. Hs36927(HSPH1), Accession No. Hs 37616(STRA13), Accession No. Hs37916(DPP7), Accession No. Hs 42806(Cab45), Accession No. Hs43297(MTPN), Accession No. Hs 47062(POLR2I), Accession No. Hs50098(NDUFA4), Accession No. Hs 50308(HIP2), Accession No. Hs50425(TEBP), Accession No. Hs 53066(HSPBP1), Accession No. Hs54277(FAM50A), Accession No. Hs 54457(CD81), Accession No. Hs54642(MAT2B), Accession No. Hs 54649(RY1), Accession No. Hs55682(EIF3S7), Accession No. Hs 55847(MRPL51), Accession No. Hs58488(CTNNAL1), Accession No. Hs 58992(SMC4L1), Accession No. Hs59486(HSDL2), Accession No. Hs 61812(PTPN12), Accession No. Hs65234(DDX27), Accession No. Hs 65238(RNF40), Accession No. Hs66048(BPY2IP1), Accession No. Hs 66915(C22orf16), Accession No. Hs68714(SFRS1), Accession No. Hs 9293(HEXB), Accession No. Hs69554(RNF126), Accession No. Hs 69855(UNR), Accession No. Hs71465(SQLE), Accession No. Hs 71787(MRPS7), Accession No. Hs73527(CSNK2B), Accession No. Hs 73722(APEX1), Accession No. Hs73799(GNAI3), Accession No. Hs 73965(SFRS2), Accession No. Hs74047(ETFB), Accession No. Hs 74050(FVT1), Accession No. Hs74137(TMP21), Accession No. Hs 74375(DVL1), Accession No. Hs74405(YWHAQ), Accession No. Hs 74471(GJA1), Accession No. Hs74563(OAZ2), Accession No. Hs 74564(SSR2), Accession No. Hs 74576(GDI1),Accession No. Hs 75056(TIMM13), Accession No. Hs 75061(MARCKSL1),Accession No. Hs 75066(TSN), Accession No. Hs 75087(FASTK), AccessionNo. Hs 75117(ILF2), Accession No. Hs 75133(TFAM), Accession No. Hs75139(ARFIP2), Accession No. Hs 75189(DAP), Accession No. Hs75227(NDUFA9), Accession No. Hs 75243(BRD2), Accession No. Hs75249(ARL6IP), Accession No. Hs 75254(IRF3), Accession No. Hs75318(TUBA1), Accession No. Hs 75348(PSME1), Accession No. Hs75438(QDPR), Accession No. Hs 75527(ADSL), Accession No. Hs75724(COPB2), Accession No. Hs 75798(C20orf111), Accession No. Hs75841(C12orf8), Accession No. Hs 75890(MBTPS1), Accession No. Hs75914(RNP24), Accession No. Hs 76111(DAG1), Accession No. Hs76394(ECHS1), Accession No. Hs 76480(UBL4), Accession No. Hs76662(ZDHHC16), Accession No. Hs 76686(GPX1), Accession No. Hs76847(GANAB), Accession No. Hs 77060(PSMB6), Accession No. Hs77269(GNAI2), Accession No. Hs 77313(CDK10), Accession No. Hs77422(PLP2), Accession No. Hs 77558(HMGN3), Accession No. Hs77578(USP9X), Accession No. Hs 77793(CSK), Accession No. Hs77897(SF3A3), Accession No. Hs 77961(HLA-B), Accession No. Hs77978(DKFZp761I2123), Accession No. Hs 78466(PSMD8), Accession No. Hs78601(UROD), Accession No. Hs 78771(PGK1), Accession No. Hs78880(ILVBL), Accession No. Hs 78888(DBI), Accession No. Hs 78989(ADHS),Accession No. Hs 79064(DHPS), Accession No. Hs 79081(PPP1CC), AccessionNo. Hs 79088(RCN2), Accession No. Hs 79101(CCNG1), Accession No. Hs79110(NCL), Accession No. Hs 79322(QARS), Accession No. Hs79335(SMARCD1), Accession No. Hs 79387(PSMC5), Accession No. Hs79402(POLR2C), Accession No. Hs 79411(RPA2), Accession No. Hs79625(C20orf149), Accession No. Hs 80545(RPL37), Accession No. Hs80919(SYPL), Accession No. Hs 80986(ATP5G1), Accession No. Hs81328(NFKBIA), Accession No. Hs 81424(SUMO1), Accession No. Hs81848(RAD21), Accession No. Hs 81964(SEC24C), Accession No. Hs82201(CSNK2A2), Accession No. Hs 82327(GSS), Accession No. Hs82719(MGC21416), Accession No. Hs 82793(PSMB3), Accession No. Hs82887(PPP1R11), Accession No. Hs 82890(DAD1), Accession No. Hs82916(CCT6A), Accession No. Hs 82927(AMPD2), Accession No. Hs83190(FASN), Accession No. Hs 83347(AAMP), Accession No. Hs83383(PRDX4), Accession No. Hs 83734(STX4A), Accession No. Hs83753(SNRPB), Accession No. Hs 83765(DHFR), Accession No. Hs83916(NDUFA5), Accession No. Hs 84359(GABARAP), Accession No. Hs84753(FLJ12442), Accession No. Hs 85155(ZFP36L1), Accession No. Hs85769(ERBP), Accession No. Hs 85962(DERPC), Accession No. Hs86131(FADD), Accession No. Hs 87752(MSN), Accession No. Hs 89545(PSMB4),Accession No. Hs 89643(TKT), Accession No. Hs 89649(EPHX1), AccessionNo. Hs 89781(UBTF), Accession No. Hs 89864(SKIV2L), Accession No. Hs90061(PGRMC1), Accession No. Hs 90093(HSPA4), Accession No. Hs90107(ADRM1), Accession No. Hs 90443(NDUFS8), Accession No. Hs91142(KHSRP), Accession No. Hs 91531(MLLT6), Accession No. Hs93659(ERP70), Accession No. Hs 93832(L0054499), Accession No. Hs95577(CDK4), Accession No. Hs 96530(COX11), Accession No. Hs96852(FLJ121128), Accession No. Hs 96996(HNRPA0), Accession No. Hs97616(SH3GL1), Accession No. Hs 97887(RCN1), Accession No. Hs98751(FUBP3), Accession No. Hs 98791(ACTR1B), Accession No. Hs102696(MCTS1), Accession No. Hs 102798(PSMA1), Accession No. Hs103561(ARL6IP4), Accession No. Hs 103834(MGC5576), Accession No. Hs104839(TIMP2), Accession No. Hs 105547(NPDC1), Accession No. Hs106185(RALGDS), Accession No. Hs 106876(ATP6VOD1), Accession No. Hs106909(ANAPC13), Accession No. Hs 107003(CCNBlIP1), Accession No. Hs107101(FLJ131031), Accession No. Hs 107387(C7orf20), Accession No. Hs107393(C3orf4), Accession No. Hs 108029(SH3BGRL), Accession No. Hs108080(CSRP1), Accession No. Hs 108371(E2F4), Accession No. Hs108408(APH-1A), Accession No. Hs 108957(RPS27L), Accession No. Hs108969(PTD008), Accession No. Hs 109051(SH3BGRL3), Accession No. Hs109052(C14orf2), Accession No. Hs 109672(SIAT7F), Accession No. Hs109798(C6orf48), Accession No. Hs 110695(SF3B5), Accession No. Hs110849(ESRRA), Accession No. Hs 111286(MRPS11), Accession No. Hs111577(ITM2C), Accession No. Hs 111801(ARS2), Accession No. Hs112058(SIVA), Accession No. Hs 112318(TOMM7), Accession No. Hs112955(NUDT5), Accession No. Hs 114033(SSR1), Accession No. Hs114286(CD9), Accession No. Hs 114412(TXNL1), Accession No. Hs115474(RFC3), Accession No. Hs 115792(EXOSC7), Accession No. Hs116448(GLS), Accession No. Hs 117176(PABPN1), Accession No. Hs117715(ST5), Accession No. Hs 118110(BST2), Accession No. Hs118400(FSCN1), Accession No. Hs 118463(PNPLA2), Accession No. Hs118638(NME1), Accession No. Hs 118722(FUT8), Accession No. Hs118964(p66a1pha), Accession No. Hs 118983(GSDMDC1), Accession No. Hs19177(ARF3), Accession No. Hs 119192(H2AFZ), Accession No. Hs119251(UQCRC1), Accession No. Hs 119591(AP2S1), Accession No. Hs119598(RPL3), Accession No. Hs 120323(DNAPTP6), Accession No. Hs121088(NUP153), Accession No. Hs 121549(CDIPT), Accession No. Hs122363(WIPI-2), Accession No. Hs 122523(SND1), Accession No. Hs124126(ARPC1A), Accession No. Hs 124147(FBXL11), Accession No. Hs124246(C10orf119), Accession No. Hs 124366(BBX), Accession No. Hs125113(CCT8), Accession No. Hs 125867(EVL), Accession No. Hs125898(GNAS), Accession No. Hs 126497(AEBP2), Accession No. Hs126774(RAMP), Accession No. Hs 126938(NAPA), Accession No. Hs127092(DHX38), Accession No. Hs 127249(EAP30), Accession No. Hs127386(MAMDC2), Accession No. Hs 127764(RABSC), Accession No. Hs128065(CTSC), Accession No. Hs 128199(SEPT11), Accession No. Hs128548(WDR1), Accession No. Hs 129634(CINP), Accession No. Hs129673(EIF4A1), Accession No. Hs 130031(TRIO), Accession No. Hs130098(DDX23), Accession No. Hs 130293(CROP), Accession No. Hs130413(TM9SF2), Accession No. Hs 131226(BNIP3L), Accession No. Hs132497(PRNPIP), Accession No. Hs 132513 HSD17B12), Accession No. Hs133892(TPM1), Accession No. Hs 134074(SLC35E1), Accession No. Hs134688(PSMD13), Accession No. Hs 135406(CEBPZ), Accession No. Hs136905(UREB1), Accession No. Hs 136947(RALY), Accession No. Hs137510(NCOR2), Accession No. Hs 138860(ARHGAP1), Accession No. Hs139896(MAEA), Accession No. Hs 140452(M6PRBP1), Accession No. Hs142442(HP1-BP74), Accession No. Hs 143187(DDX49), Accession No. Hs143766(DRPLA), Accession No. Hs 143873(S100A10), Accession No. Hs144058(EBSP), Accession No. Hs 144468(MGC3234), Accession No. Hs144835(EEF1G), Accession No. Hs 144868(VTI1B), Accession No. Hs144941(MUF1), Accession No. Hs 144949(ZNF313), Accession No. Hs144980(SCAMP4), Accession No. Hs 145049(PLEKHM2), Accession No. Hs145442(MAP2K1), Accession No. Hs 145575(UBL3), Accession No. Hs146070(TPM3), Accession No. Hs 146393(HERPUD1), Accession No. Hs146602(QP-C), Accession No. Hs 146804(SPIN), Accession No. Hs146806(CUL1), Accession No. Hs 147433(PCNA), Accession No. Hs148078(RBAF600), Accession No. Hs 148272(CCM2), Accession No. Hs148330(ARF4), Accession No. Hs 148340(PTPRG), Accession No. Hs148670(RHOBTB1), Accession No. Hs 149004(FBXO31), Accession No. Hs149957(RPS6KA1), Accession No. Hs 149983(PEX14), Accession No. Hs150107(BIRC6), Accession No. Hs 150540(BC002942), Accession No. Hs150580(SUI1), Accession No. Hs 150837(TXNDC5), Accession No. Hs151134(OXA1L), Accession No. Hs 151220(KIAA0992), Accession No. Hs151413(GMFB), Accession No. Hs 151787(U5-116KD), Accession No. Hs152536(p44S10), Accession No. Hs 153177(RPS28), Accession No. Hs154023(TXNDC4), Accession No. Hs 154073(SLC35B1), Accession No. Hs155165(ZFPL1), Accession No. Hs 155218(HNRPUL1), Accession No. Hs155396(NFE2L2), Accession No. Hs 155829(KIAA0676), Accession No. Hs156171(PSMC6), Accession No. Hs 156367(RPS29), Accession No. Hs156667(KIAA1536), Accession No. Hs 157160(MRPS34), Accession No. Hs157351(PTD004), Accession No. Hs 157379(H2AFV), Accession No. Hs157394(HAGH), Accession No. Hs 159014(PRPF4B), Accession No. Hs159118(AMD1), Accession No. Hs 159130(RAF1), Accession No. Hs159161(ARHGDIA), Accession No. Hs 159699(FBXO21), Accession No. Hs159799(THRAP2), Accession No. Hs 160958(CDC37), Accession No. Hs161357(PDHB), Accession No. Hs 162032(HBP1), Accession No. Hs162233(CHD4), Accession No. Hs 162877(PACSIN2), Accession No. Hs163645(MOCS2), Accession No. Hs 163776(UBE2J1), Accession No. Hs163893(PICALM), Accession No. Hs 165195(VAPA), Accession No. Hs166011(CTNND1), Accession No. Hs 166204(PHF1), Accession No. Hs166463(HNRPU), Accession No. Hs 166924(SEC13L1), Accession No. Hs166975(SFRS5), Accession No. Hs 167535(SRP54), Accession No. Hs168073(TRPC4AP), Accession No. Hs 168799(METTL3), Accession No. Hs169611(DIABLO), Accession No. Hs 169718(CNN2), Accession No. Hs170107(UQCRFS1), Accession No. Hs 170131(NFIC), Accession No. Hs170553(CNOT7), Accession No. Hs 170622(CFL1), Accession No. Hs171626(SKP1A), Accession No. Hs 172550(PTBP1), Accession No. Hs172755(BRP44L), Accession No. Hs 172928(COL1A1), Accession No. Hs173024(NYREN18), Accession No. Hs 173162(NOC4), Accession No. Hs173381(DPYSL2), Accession No. Hs 173464(FKBP8), Accession No. Hs173611(NDUFS2), Accession No. Hs 173705(LOC401152), Accession No. Hs173724(CKB), Accession No. Hs 174050(EDF1), Accession No. Hs174195(IFITM2), Accession No. Hs 175473(AK1), Accession No. Hs175955(YT521), Accession No. Hs 177530(ATPSE), Accession No. Hs177766(PARP1), Accession No. Hs 178551(RPL8), Accession No. Hs178728(MBD3), Accession No. Hs 179986(FLOT1), Accession No. Hs180141(CFL2), Accession No. Hs 180312(MRPS16), Accession No. Hs180414(HSPA8), Accession No. Hs 180877(H3F3B), Accession No. Hs180903(384D8-2), Accession No. Hs 180909(PRDX1), Accession No. Hs180933(CXXC1), Accession No. Hs 181046(DUSP3), Accession No. Hs181112(MED4), Accession No. Hs 181163(HMGN2), Accession No. Hs181244(HLA-A), Accession No. Hs 181368(PRPF8), Accession No. Hs181444(TMEM9), Accession No. Hs 182255(NHP2L1), Accession No. Hs182626(C22orf5), Accession No. Hs 182885(SLC35B2), Accession No. Hs183684(EIF4G2), Accession No. Hs 183706(ADD1), Accession No. Hs183800(RANGAP1), Accession No. Hs 183850(DCTD), Accession No. Hs183994(PPP1CA), Accession No. Hs 184062(C20orf24), Accession No. Hs184211(PMPCB), Accession No. Hs 184233(HSPA9B), Accession No. Hs184492(ELAVL1), Accession No. Hs 185172(GNB2), Accession No. Hs185597(SPG7), Accession No. Hs 187199(MALAT1), Accession No. Hs187635(RPS15A), Accession No. Hs 187763(BRD4), Accession No. Hs187866(SDFR1), Accession No. Hs 187946(SLC20A1), Accession No. Hs188501(PAFAH1B2), Accession No. Hs 188614(PLEKHA5), Accession No. Hs188879(RBM6), Accession No. Hs 188882(NUDT3), Accession No. Hs189075(PTK9), Accession No. Hs 189119(CXXC5), Accession No. Hs189329(SMURF1), Accession No. Hs 189716(NDUFAB1), Accession No. Hs189772(CCT2), Accession No. Hs 190028(GSTO1), Accession No. Hs190086(MRCL3), Accession No. Hs 190334(RAP1A), Accession No. Hs190384(COPS4), Accession No. Hs 190722(HSPC142), Accession No. Hs190904(STRN4), Accession No. Hs 191186(TTC17), Accession No. Hs191346(SEPT7), Accession No. Hs 191518(DHX9), Accession No. Hs191987(UBE2J2), Accession No. Hs 192316(CDC2L1), Accession No. Hs192374(TRA1), Accession No. Hs 192425(EIF3S8), Accession No. Hs193118(RAI17), Accession No. Hs 193163(BIN1), Accession No. Hs193491(TUBB6), Accession No. Hs 194329(TCEAL4), Accession No. Hs194718(ZNF265), Accession No. Hs 195464(FLNA), Accession No. Hs195642(C17orf27), Accession No. Hs 196983(SSFA2), Accession No. Hs198281(PKM2), Accession No. Hs 199561(RANBP2), Accession No. Hs199625(HAX1), Accession No. Hs 200063(HDAC7A), Accession No. Hs200600(SCAMP3), Accession No. Hs 200804(SDCBP), Accession No. Hs201253(ch-TOG), Accession No. Hs 201390(WDR45L), Accession No. Hs201712(GLG1), Accession No. Hs 202011(GK001), Accession No. Hs202085(VDAC1), Accession No. Hs 202166(HNRPH1), Accession No. Hs202179(SMN2), Accession No. Hs 203099(KIAA0261), Accession No. Hs203910(SGTA), Accession No. Hs 204041(AHSA1), Accession No. Hs204773(MEP50), Accession No. Hs 205163(MRPL3), Accession No. Hs206500(CTTN), Accession No. Hs 206824(MGC71993), Accession No. Hs208597(CTBP1), Accession No. Hs 209983(STMN1), Accession No. Hs210469(ELMO2), Accession No. Hs 210532(KIAA0141), Accession No. Hs211463(DNM2), Accession No. Hs 211594(PSMC4), Accession No. Hs211914(NDUFS7), Accession No. Hs 212102(TXNDC7), Accession No. Hs212395(CIZ1), Accession No. Hs 213061(NUCKS), Accession No. Hs213470(PSMB7), Accession No. Hs 213541, Accession No. Hs213666(KIAA0460), Accession No. Hs 213724(SUPT16H), Accession No. Hs216653(FBXO9), Accession No. Hs 220950(FOXO3A), Accession No. Hs221847(SLC38A2), Accession No. Hs 222510(DAZAP1), Accession No. Hs223141(DDX21), Accession No. Hs 224607(SDC1), Accession No. Hs226007(RDH11), Accession No. Hs 226117(H1F0), Accession No. Hs226755(YWHAH), Accession No. Hs 227067(ATAD3A), Accession No. Hs227253(TOMM70A), Accession No. Hs 227777(PTP4A1), Accession No. Hs229641(PC4), Accession No. Hs 231295(PITPNC1), Accession No. Hs231616(HSPCO23), Accession No. Hs 232194(KIAA0174), Accession No. Hs232543(PDCD4), Accession No. Hs 233458(NFYC), Accession No. Hs233552(CDC2L5), Accession No. Hs 233952(PSMA7), Accession No. Hs234521(MAPKAPK3), Accession No. Hs 236030(SMARCC2), Accession No. Hs237536(MGC20781), Accession No. Hs 237971(XTP3TPA), Accession No. Hs238839(SCYL1), Accession No. Hs 240170(MGC2731), Accession No. Hs241336(ATPIF1), Accession No. Hs 241543(POLDIP2), Accession No. Hs241558(ARIH2), Accession No. Hs 241575(GNPTG), Accession No. Hs241576(DERL1), Accession No. Hs 241579(SERPINH1), Accession No. Hs242458(SPG21), Accession No. Hs 242947(DGKI), Accession No. Hs246112(ASCC3L1), Accession No. Hs 246310(ATP5J), Accession No. Hs246413(CPNE1), Accession No. Hs 246781(FBXO11), Accession No. Hs247077(RHOA), Accession No. Hs 247186(FBS1), Accession No. Hs247975(HSPD1), Accession No. Hs 248267(MPST), Accession No. Hs248941(TAF9), Accession No. Hs 49600(DLGAP4), Accession No. Hs250009(ARL10C), Accession No. Hs 250429(SUPT6H), Accession No. Hs250758(PSMC3), Accession No. Hs 250899(HSBP1), Accession No. Hs250905(L0051234), Accession No. Hs 251531(PSMA4), Accession No. Hs252457(MVD), Accession No. Hs 252713(TTC15), Accession No. Hs 252967DKFZp566C0424), Accession No. Hs 253726(PAPOLA), Accession No. Hs253903(STOM), Accession No. Hs 254042(BAT1), Accession No. Hs255015(VPS24), Accession No. Hs 255093(PFKL), Accession No. Hs255932(XRN2), Accession No. Hs 255935(BTG1), Accession No. Hs255973(CRI1), Accession No. Hs 256301(MGC13170), Accession No. Hs256549(NUBP2), Accession No. Hs 257008(PLD3), Accession No. Hs257341(SAV1), Accession No. Hs 57761(SH3BP5), Accession No. Hs258551(DNPEP), Accession No. Hs 258563(FEZ2), Accession No. Hs 258798C10orf86), Accession No. Hs 259461(PALM2-AKAP2), Accession No. Hs260603(PIP5K2B), Accession No. Hs 262823(FLJ10326), Accession No. Hs265829(ITGA3), Accession No. Hs 268488(KIAA1185), Accession No. Hs268530(GPS1), Accession No. Hs 268742(C13orf12), Accession No. Hs268849(GLO1), Accession No. Hs 268939(MATR3), Accession No. Hs269528(MAK3), Accession No. Hs 269577(PTPRA), Accession No. Hs269782(GNAQ), Accession No. Hs 269944(MTCH2), Accession No. Hs270291(ACTN4), Accession No. Hs 270428(SUCLG1), Accession No. Hs270525(LASS5), Accession No. Hs 270869(ZNF410), Accession No. Hs271135(ATP5C1), Accession No. Hs 271695(NOB1P), Accession No. Hs272062(PTPRF), Accession No. Hs 272168(TDE1), Accession No. Hs272630(ATP6V1D), Accession No. Hs 272927(SEC23A), Accession No. Hs273077(TMEM14B), Accession No. Hs 274184(TFE3), Accession No. Hs274772(C15orf15), Accession No. Hs 274873(CARS), Accession No. Hs275243(S100A6), Accession No. Hs 275775(SEPP1), Accession No. Hs275865(PCNP), Accession No. Hs 276878(NUP93), Accession No. Hs277035(MGLL), Accession No. Hs 277517(C11orf2), Accession No. Hs278186(ARHGEF1), Accession No. Hs 278362(MEA), Accession No. Hs278426(PDAP1), Accession No. Hs 278429(C9orf78), Accession No. Hs278500(GNPDA1), Accession No. Hs 278569(SNX17), Accession No. Hs278573(CD59), Accession No. Hs 278721(SLC39A7), Accession No. Hs279061(C17orf25), Accession No. Hs 279245(TACC1), Accession No. Hs279257(PCMT1), Accession No. Hs 279413(POLD1), Accession No. Hs279529(PX19), Accession No. Hs 279583(DREV1), Accession No. Hs279623(SEPX1), Accession No. Hs 279640(TPR), Accession No. Hs279652(MRPL4), Accession No. Hs 279669(TUBG1), Accession No. Hs279696(SUMF2), Accession No. Hs 279806(DDX5), Accession No. Hs79836(COMMD9), Accession No. Hs 279920(YWHAB), Accession No. Hs279929(TMED9), Accession No. Hs 80202(SBF1), Accession No. Hs280342(PRKAR1A), Accession No. Hs 280378(SNRPB2), Accession No. Hs282410(CALM1), Accession No. Hs 282700(SPCS2), Accession No. Hs282901(RNPC2), Accession No. Hs 282998(RBM9), Accession No. Hs283111(C14orf124), Accession No. Hs 283454(BNIP2), Accession No. Hs283521(RHEB), Accession No. Hs 283610(APG4B), Accession No. Hs283652(IDI1), Accession No. Hs 283739(UBQLN4), Accession No. Hs284208(ANKRD25), Accession No. Hs 284279(HMOX2), Accession No. Hs284286(MRPS24), Accession No. Hs 284491(PDXK), Accession No. Hs285354(MAX), Accession No. Hs 285976(LASS2), Accession No. Hs286221(ARF1), Accession No. Hs 286226(MYO1C), Accession No. Hs288193(KPNA4), Accession No. Hs 288856(PFDN5), Accession No. Hs288969(HSCARG), Accession No. Hs 289008(C6orf68), Accession No. Hs289092(COTL1), Accession No. Hs 289123(DCTN2), Accession No. Hs289271(CYC1), Accession No. Hs 290243(GBF1), Accession No. Hs290404(SLC25A3), Accession No. Hs 290758(DDB1), Accession No. Hs291587(ARID1B), Accession No. Hs 292026(EIF4E2), Accession No. Hs292063(EIF4B), Accession No. Hs 292078(LARP), Accession No. Hs292265(ZMYND11), Accession No. Hs 292457, Accession No. Hs292493(G22P1), Accession No. Hs 292524(CCNH), Accession No. Hs292579(PTDSS1), Accession No. Hs 293563(FLJ12666), Accession No. Hs295917(ATP6V1B2), Accession No. Hs 297324(TIMP3), Accession No. Hs298198(CKLFSF3), Accession No. Hs 298280(ATP5A1), Accession No. Hs298654(DUSP6), Accession No. Hs 299002(FBL), Accession No. Hs299055(GDI2), Accession No. Hs 300141(RPL39), Accession No. Hs300684(RCP9), Accession No. Hs 300772(TPM2), Accession No. Hs 300816RAB1B), Accession No. Hs 300834(GALNT2), Accession No. Hs 301404(RBM3),Accession No. Hs 301412(Ufc1), Accession No. Hs 302742(MRPS6), AccessionNo. Hs 302903(UBE2I), Accession No. Hs 303676(G3BP2), Accession No. Hs304192(DSTN), Accession No. Hs 304682(CST3), Accession No. Hs306123(MAGEF1), Accession No. Hs 306242(RANBP9), Accession No. Hs306329(ZA20D3), Accession No. Hs 306425(IBTK), Accession No. Hs308122(ITPK1), Accession No. Hs 308340(NUP188), Accession No. Hs308709(GRP58), Accession No. Hs 309090(SFRS7), Accession No. Hs309231(C6orf153), Accession No. Hs 309641(RNFLJ1), Accession No. Hs309753(STARD3NL), Accession No. Hs 309849(C14orf159), Accession No. Hs310542(TOMM40), Accession No. Hs 310645(RAB1A), Accession No. Hs311072(MRPS35), Accession No. Hs 311346(CMAS), Accession No. Hs311609(DDX39), Accession No. Hs 311640(RPS27A), Accession No. Hs312098(ADAM15), Accession No. Hs 313847(TXNDC11), Accession No. Hs314263(BAZ2A), Accession No. Hs 314359(EIF3S12), Accession No. Hs315177(IFRD2), Accession No. Hs 315230(GC20), Accession No. Hs319334(NASP), Accession No. Hs 321391(MGC4549), Accession No. Hs321541(RAB11A), Accession No. Hs 323363(APG9L1), Accession No. Hs323489(FLJ120758), Accession No. Hs 324250(NDUFB2), Accession No. Hs324844(VKORC1), Accession No. Hs 325650(EHD2), Accession No. Hs326387(MORF4L2), Accession No. Hs 330384(CORO1C), Accession No. Hs331431(SCC-112), Accession No. Hs 333388(EEF1D), Accession No. Hs333579(HSPC152), Accession No. Hs 333786(PSMA2), Accession No. Hs333823(MRPL13), Accession No. Hs 334017(K-ALPHA-1), Accession No. Hs334479(TRAF7), Accession No. Hs 334534(GNS), Accession No. Hs334587(RBPMS), Accession No. Hs 334713(BMSC-UbP), Accession No. Hs334851(LASP1), Accession No. Hs 334868(PPP2R5E), Accession No. Hs335003(ANKRD11), Accession No. Hs 335057(SEPT2), Accession No. Hs335163(KIAA1102), Accession No. Hs 335918(FDPS), Accession No. Hs337295(STIP1), Accession No. Hs 337766(TXNRD1), Accession No. Hs339278(COPB), Accession No. Hs 339639(COX7A2L), Accession No. Hs339697(GRINA), Accession No. Hs 343911(E124), Accession No. Hs345694(KCMF1), Accession No. Hs 346868(EBNA1BP2), Accession No. Hs348418(DR1), Accession No. Hs 349656(SCARB2), Accession No. Hs350194(ZMAT2), Accession No. Hs 350229(CASC3), Accession No. Hs350268(IRF2BP2), Accession No. Hs 350364(C9orf10OS), Accession No. Hs350927(SLC25A6), Accession No. Hs 351099(FLJ10241), Accession No. Hs351296(L0051035), Accession No. Hs 351316(TM4SF1), Accession No. Hs351474(PAQR4), Accession No. Hs 351680, Accession No. Hs 351875(COX6C),Accession No. Hs 352341(STCH), Accession No. Hs 352656(GHITM), AccessionNo. Hs 352768(PSMB1), Accession No. Hs 354056(POR), Accession No. Hs355141(TNIP1), Accession No. Hs 355606(MGC23909), Accession No. Hs355643(RNPS1), Accession No. Hs 355708(FLJ120507), Accession No. Hs355750(MGC5306), Accession No. Hs 355753(DKFZp586M1819), Accession No.Hs 355867(MARS), Accession No. Hs 355927(VDAC2), Accession No. Hs355934(SFPQ), Accession No. Hs 355983(BZW1), Accession No. Hs356061(MAP1LC3B), Accession No. Hs 356096(FLJ10350), Accession No. Hs356190(UBB), Accession No. Hs 356270(SDHD), Accession No. Hs356285(HMGN1), Accession No. Hs 356331(PPIA), Accession No. Hs356366(RPS2), Accession No. Hs 356371(RPL28), Accession No. Hs356377(LOC149603), Accession No. Hs 356467(MGC2747), Accession No. Hs356501(PHF6), Accession No. Hs 356502(RPLP1), Accession No. Hs356549(SNRPD3), Accession No. Hs 356630(NUTF2), Accession No. Hs356647(SNX6), Accession No. Hs 356654(PSMC1), Accession No. Hs 567660,Accession No. Hs 356769(MAN2B1), Accession No. Hs 356799, Accession No.Hs 357901(SOX4), Accession No. Hs 362728(SEP15), Accession No. Hs365116(U2AF1), Accession No. Hs 368084(LRPPRC), Accession No. Hs368149(CCT7), Accession No. Hs 368157(PYGB), Accession No. Hs368240(DYRK1A), Accession No. Hs 68264(PPP2R5C), Accession No. Hs368376(SRPR), Accession No. Hs 368402(L0051337), Accession No. Hs368404(EXT2), Accession No. Hs 368525(PDLIM1), Accession No. Hs368598(LEREPO4), Accession No. Hs 368934(MGC40157), Accession No. Hs368985(TRIP12), Accession No. Hs 369017(RAB2), Accession No. Hs369052(SELT), Accession No. Hs 369068(DNCLI2), Accession No. Hs369125(PSMD14), Accession No. Hs 369285(DKFZP434B168), Accession No. Hs369356(MLL5), Accession No. Hs 369606(CPSF6), Accession No. Hs369607(GAK), Accession No. Hs 369614(COPS2), Accession No. Hs369615(FLJ120551), Accession No. Hs 369761(DAZAP2), Accession No. Hs369785(MGC2749), Accession No. Hs 369920(RAP1B), Accession No. Hs370024(SEC31L1), Accession No. Hs 370247(APLP2), Accession No. Hs370292(BCCIP), Accession No. Hs 370312(FNTA), Accession No. Hs370408(COMT), Accession No. Hs 370581(CAP1), Accession No. Hs370770(XPO1), Accession No. Hs 370771(CDKN1A), Accession No. Hs370895(RPN2), Accession No. Hs 370927(PRO1855), Accession No. Hs370937(TAPBP), Accession No. Hs 371001(EIF3S9), Accession No. Hs371416(CARM1), Accession No. Hs 371563(RAB14), Accession No. Hs371788(DKFZP547E1010), Accession No. Hs 371889(ATP1A1), Accession No. Hs372003(C9orf10), Accession No. Hs 372050(SMAP-5), Accession No. Hs372286(CUL3), Accession No. Hs 372331(SPTAN1), Accession No. Hs372541(KBTBD2), Accession No. Hs 372616(ARL1), Accession No. Hs372914(NDRG1), Accession No. Hs 373550(TGIF), Accession No. Hs373741(HM13), Accession No. Hs 373763(HNRPR), Accession No. Hs373952(CAMTA2), Accession No. Hs 373959(VGLL4), Accession No. Hs374043(ASXL1), Accession No. Hs 374257(SIAT4A), Accession No. Hs374378(CKS1B), Accession No. Hs 374477(EWSR1), Accession No. Hs374503(MORF4L1), Accession No. Hs 374588(RPL17), Accession No. Hs374596(TPT1), Accession No. Hs 374650(IFITM3), Accession No. Hs374973(PRPF4), Accession No. Hs 375001(TLN1), Accession No. Hs375108(CD24), Accession No. Hs 375217(RNF31), Accession No. Hs376046(BTN3A2), Accession No. Hs 376933(GUK1), Accession No. Hs377155(LYRIC), Accession No. Hs 378103(RPS5), Accession No. Hs378532(HBS1L), Accession No. Hs 378808(eIF2A), Accession No. Hs380403(PCGF4), Accession No. Hs 380774(DDX3X), Accession No. Hs380953(RPL38), Accession No. Hs 380973(SUMO2), Accession No. Hs381008(HLA-E), Accession No. Hs 381058(KIAA0146), Accession No. Hs381072(PPIF), Accession No. Hs 381123(RPL21), Accession No. Hs381126(RPS14), Accession No. Hs 381189(CBX3), Accession No. Hs 381219,Accession No. Hs 381256(GLTP), Accession No. Hs 382044(MRPS2), AccessionNo. Hs 382168(NCOA3), Accession No. Hs 385913(ANP32E), Accession No. Hs385986(UBE2B), Accession No. Hs 386434(ANXA7), Accession No. Hs386465(CHERP), Accession No. Hs 386939(USP7), Accession No. Hs387208(FAU), Accession No. Hs 387804(PABPC1), Accession No. Hs388034(RXRB), Accession No. Hs 388654(ATP6V1G1), Accession No. Hs388664(RPL11), Accession No. Hs 388739(XRCCS), Accession No. Hs388927(YY1), Accession No. Hs 388956(C19orf22), Accession No. Hs389037(MCM3APAS), Accession No. Hs 389107(ATP6VOC), Accession No. Hs389171(PINK1), Accession No. Hs 389649(DDX48), Accession No. Hs389734(TCEAL8), Accession No. Hs 389996(CHCHD2), Accession No. Hs390667(GSTK1), Accession No. Hs 393201(ACTR2), Accession No. Hs395482(PTK2), Accession No. Hs 396644(PAIP2), Accession No. Hs396740(NIP30), Accession No. Hs 396783(SLC9A3R1), Accession No. Hs397609(RPS16), Accession No. Hs 399800(AKAP8L), Accession No. Hs400295(RPL30), Accession No. Hs 401509(RBM10), Accession No. Hs401903(COX5A), Accession No. Hs 401929(RPL10), Accession No. Hs403917(STK24), Accession No. Hs 404056(EIF3S1), Accession No. Hs404321(GARS), Accession No. Hs 405144(SFRS3), Accession No. Hs405410(OGT), Accession No. Hs 405514(LOC284058), Accession No. Hs405590(EIF3S6), Accession No. Hs 405880(MRPS21), Accession No. Hs405942(LOC339229), Accession No. Hs 406062(NDUFA11), Accession No. Hs406068(UBE2M), Accession No. Hs 406096(ZA20D2), Accession No. Hs406277(SF3A1), Accession No. Hs 406300(RPL23), Accession No. Hs406423(SF3B2), Accession No. Hs 406510(ATP5B), Accession No. Hs406520(LOC389541), Accession No. Hs 406534(HMG20B), Accession No. Hs406590(PGR1), Accession No. Hs 406620(RPS10), Accession No. Hs406683(RPS15), Accession No. Hs 406799(RAB18), Accession No. Hs406840(SLC35A4), Accession No. Hs 407368(C19orf13), Accession No. Hs407580(PKP4), Accession No. Hs 407995(MIF), Accession No. Hs408018(RPL36), Accession No. Hs 408073(RPS6), Accession No. Hs408236(TXNL5), Accession No. Hs 408257(NDUFS6), Accession No. Hs408293(KAB), Accession No. Hs 408324(FLJ10769), Accession No. Hs408428(CHES1), Accession No. Hs 408581(SVIL), Accession No. Hs408909(GOLPH3), Accession No. Hs 409140(ATP5O), Accession No. Hs409223(SSR4), Accession No. Hs 409230(AGPAT1), Accession No. Hs409834(PHPT1), Accession No. Hs 410197(IDH3G), Accession No. Hs410596(HAN11), Accession No. Hs 410817(RPL13), Accession No. Hs411480(AUP1), Accession No. Hs 411641(EIF4EBP1), Accession No. Hs411847(MAPK6), Accession No. Hs 412103(EFHA1), Accession No. Hs412117(ANXA6), Accession No. Hs 412196(ESRRBL1), Accession No. Hs412433(AIP), Accession No. Hs 412468(KLHDC3), Accession No. Hs412842(C10orf7), Accession No. Hs 413036(WBSCR22), Accession No. Hs413482(C21orf33), Accession No. Hs 414579(SCOTIN), Accession No. Hs415342(KIAA1049), Accession No. Hs 416049(TNPO2), Accession No. Hs416436(TRIM50A), Accession No. Hs 417004(S100A11), Accession No. Hs417029(DERP6), Accession No. Hs 418123(CTSL), Accession No. Hs418175(VPS28), Accession No. Hs 418233(MRPL24), Accession No. Hs418450(MRPL11), Accession No. Hs 418533(BUB3), Accession No. Hs418668(ATPSD), Accession No. Hs 419640(PARK7), Accession No. Hs420269(COL6A2), Accession No. Hs 420272(H2AFY), Accession No. Hs421257(RPL7), Accession No. Hs 421509(CCT4), Accession No. Hs422113(ZNF511), Accession No. Hs 423935(RDBP), Accession No. Hs423968(TTC11), Accession No. Hs 424126(SERF2), Accession No. Hs424908(LSM5), Accession No. Hs 425777(UBE2L6), Accession No. Hs426296(C10orf104), Accession No. Hs 426359(DKFZp564J157), Accession No.Hs 429052(ITGB1), Accession No. Hs 429353(SEPN1), Accession No. Hs429581(RTN4), Accession No. Hs 429819(PITPNA), Accession No. Hs429839(MGC23908), Accession No. Hs 430425(GNB1), Accession No. Hs430551(IQGAP1), Accession No. Hs 430606(CS), Accession No. Hs430657(ARF5), Accession No. Hs 430733(CLNS1A), Accession No. Hs431101(GNG12), Accession No. Hs 431367(C6orf55), Accession No. Hs431498(FOXP1), Accession No. Hs 431550(MAP4K4), Accession No. Hs431668(COX6B1), Accession No. Hs 431850(MAPK1), Accession No. Hs431861(PPP5C), Accession No. Hs 431926 NFKB1), Accession No. Hs432121(PRDX2), Accession No. Hs 432438(EML4), Accession No. Hs432491(ESD), Accession No. Hs 432690(SLC39A9), Accession No. Hs432760(CAPZB), Accession No. Hs 432898(RPL4), Accession No. Hs432976(NR1H2), Accession No. Hs 433154(PLSCR3), Accession No. Hs433201(CDK2AP1), Accession No. Hs 433222(NPC2), Accession No. Hs433291(ARD1), Accession No. Hs 433307(BCKDHA), Accession No. Hs433343(SRRM2), Accession No. Hs 433345, Accession No. Hs 433419(COX4I1),Accession No. Hs 433512(ACTR3), Accession No. Hs 433529(RPS11),Accession No. Hs 433540(DNAJC8), Accession No. Hs 433573(Bles03),Accession No. Hs 433615(TUBB2), Accession No. Hs 433701(RPL37A),Accession No. Hs 433722(KIAA1967), Accession No. Hs 33732(CLK1),Accession No. Hs 433750(EIF4G1), Accession No. Hs 433759(BANF1),Accession No. Hs 433795(SHC1), Accession No. Hs 433863(PBP), AccessionNo. Hs 433901(COX8A), Accession No. Hs 433951(GPX4), Accession No. Hs434102(HMGB1), Accession No. Hs 434207(HARS2), Accession No. Hs434219(ANKHD1), Accession No. Hs 434401(ZNF638), Accession No. Hs434937(PPIB), Accession No. Hs 434953(HMGB2), Accession No. Hs434980(APP), Accession No. Hs 435044(TBC1D22A), Accession No. Hs435064(KIAA1608), Accession No. Hs 435120(KIF1C), Accession No. Hs435136(TXN), Accession No. Hs 435166(LBR), Accession No. Hs 435231(ZFR),Accession No. Hs 435255(UBXD1), Accession No. Hs 435326(ACTL6A),Accession No. Hs 435512(PPP3CA), Accession No. Hs 435535(ZNF395),Accession No. Hs 435610(WAC), Accession No. Hs 435741(GCSH), AccessionNo. Hs 435759(THAP4), Accession No. Hs 435771(APIS), Accession No. Hs435841(TNRC15), Accession No. Hs 435850(LYPLA1), Accession No. Hs435933(PHF10), Accession No. Hs 435948(ATAD1), Accession No. Hs435952(CDK5RAP1), Accession No. Hs 435974(MTHFD1), Accession No. Hs436035(TUBA6), Accession No. Hs 436093(BAT2), Accession No. Hs436204(ZNF289), Accession No. Hs 436298(EMP1), Accession No. Hs436405(IDH3B), Accession No. Hs 436437(ALDH2), Accession No. Hs436446(ARMET), Accession No. Hs 436500(DBNL), Accession No. Hs436568(CD74), Accession No. Hs 436578(POLR2F), Accession No. Hs436657(CLU), Accession No. Hs 436687(SET), Accession No. Hs436803(VBP1), Accession No. Hs 437056(SUPT5H), Accession No. Hs437060(CYC5), Accession No. Hs 437110(ANXA2), Accession No. Hs437178(ACADVL), Accession No. Hs 437256(GRINL1A), Accession No. Hs437277(MGAT4B), Accession No. Hs 437367(GBAS), Accession No. Hs437388(PIGT), Accession No. Hs 437403(PP), Accession No. Hs437594(RPLP2), Accession No. Hs 437638(XBP1), Accession No. Hs437779(C11orf10), Accession No. Hs 437831(C14orf32), Accession No. Hs438072(UNC84A), Accession No. Hs 438219(GPS2), Accession No. Hs438429(RPS19), Accession No. Hs 438678(TALDO1), Accession No. Hs438720(MCM7), Accession No. Hs 438970(TBL1XR1), Accession No. Hs438974(CUTL1), Accession No. Hs 439480(RBM5), Accession No. Hs439481(SUPT4H1), Accession No. Hs 439548(FLJ122875), Accession No. Hs439552, Accession No. Hs 439815(HBXIP), Accession No. Hs 440382(RFP),Accession No. Hs 440544(CLIC4), Accession No. Hs 440599(DDX1), AccessionNo. Hs 440604(PSMD7), Accession No. Hs 440899(TTYH3), Accession No. Hs440932(SEPT9), Accession No. Hs 440960(RAD23A), Accession No. Hs440961(CAST), Accession No. Hs 441072(POLR2L), Accession No. Hs441550(C20orf22), Accession No. Hs 442344(IRS2), Accession No. Hs442798(RNF10), Accession No. Hs 443134(GBA2), Accession No. Hs443379(PSMD11), Accession No. Hs 443837(NPEPPS), Accession No. Hs443914(SOD1), Accession No. Hs 444279(DKFZp761C169), Accession No. Hs444356(GRB2), Accession No. Hs 444468(CTDSP1), Accession No. Hs444472(SDHC), Accession No. Hs 444569(VMP1), Accession No. Hs444673(CRR9), Accession No. Hs 444724(AZI2), Accession No. Hs444818(CGGBP1), Accession No. Hs 444931(CRSP6), Accession No. Hs444969(C2orf4), Accession No. Hs 444986(METAP2), Accession No. Hs445081(NS5ATP13TP2), Accession No. Hs 445351(LGALS1), Accession No. Hs445394(VPS29), Accession No. Hs 445498(SKIIP), Accession No. Hs445511(RIOK3), Accession No. Hs 445570(CD63), Accession No. Hs445803(DC2), Accession No. Hs 445893(KHDRBS1), Accession No. Hs445977(GTF3A), Accession No. Hs 446017(WSB1), Accession No. Hs446091(WTAP), Accession No. Hs 446123(CAPZA2), Accession No. Hs446149(LDHB), Accession No. Hs 446260(PSMA6), Accession No. Hs446336(PXN), Accession No. Hs 446345(FTH1), Accession No. Hs446414(CD47), Accession No. Hs 446427(OAZ1), Accession No. Hs446445(YIF1), Accession No. Hs 446450(ITM2B), Accession No. Hs446574(TMSB10), Accession No. Hs 446588(RPS13), Accession No. Hs446623(HNRPL), Accession No. Hs 446628(RPS4X), Accession No. Hs446641(ARAF), Accession No. Hs 446852(EIF3S6IP), Accession No. Hs447477(ST13), Accession No. Hs 447492(PGAM1), Accession No. Hs447547(VPS35), Accession No. Hs 48226(RPLP0), Accession No. Hs448588(NGFRAP1), Accession No. Hs 448646(RPL27A), Accession No. Hs448879, Accession No. Hs 449114(HNRPC), Accession No. Hs 449171(HNRPK),Accession No. Hs 454534(USF2), Accession No. Hs 454699(IL6ST), AccessionNo. Hs 456507(PKD1-like), Accession No. Hs 456557(FLJ10597), AccessionNo. Hs 458320(DC12), Accession No. Hs 458358(TSPYL1), Accession No. Hs458414(IFITM1), Accession No. Hs 458458(C19orf27), Accession No. Hs458747(ANP32A), Accession No. Hs 459106(OAZIN), Accession No. Hs459149(BTBD1), Accession No. Hs 459174(FLJ123790), Accession No. Hs459211(AKAP13), Accession No. Hs 459596(MPG), Accession No. Hs459649(CLCN7), Accession No. Hs 459927(PTMA), Accession No. Hs459940(LITAF), Accession No. Hs 460238(SH3GLB2), Accession No. Hs460317(ALS4), Accession No. Hs 460336(GGA2), Accession No. Hs460468(XPO6), Accession No. Hs 460499(ATXN2L), Accession No. Hs460574(LOC124446), Accession No. Hs 460923(CNOT1), Accession No. Hs460929(GOT2), Accession No. Hs 460978(APPBP1), Accession No. Hs461047(G6PD), Accession No. Hs 461131(CYBS-M), Accession No. Hs461361(CFDP1), Accession No. Hs 461379(GABARAPL2), Accession No. Hs461722(HSPC176), Accession No. Hs 461777(PCOLN3), Accession No. Hs461896(CRK), Accession No. Hs 461925(RPA1), Accession No. Hs462035(UBE2G1), Accession No. Hs 462086(RIP), Accession No. Hs462306(UBE2S), Accession No. Hs 462316(TTC19), Accession No. Hs462492(USP22), Accession No. Hs 462550(PIGS), Accession No. Hs462956(PPARBP), Accession No. Hs 462998(IGFBP4), Accession No. Hs463010(SMARCE1), Accession No. Hs 463035(FKBP10), Accession No. Hs463041(RERE), Accession No. Hs 463059(STAT3), Accession No. Hs463295(CDC27), Accession No. Hs 463506(AKAP1), Accession No. Hs463702(BCAS3), Accession No. Hs 463797(C1orf33), Accession No. Hs464071(PGD), Accession No. Hs 464137(ACOX1), Accession No. Hs464210(SYNGR2), Accession No. Hs 464336(P4HB), Accession No. Hs464438(AGTRAP), Accession No. Hs 464472(MRLC2), Accession No. Hs464595(PPP4R1), Accession No. Hs 464652(TNFSF5IP1), Accession No. Hs464912(P15RS), Accession No. Hs 465224(NARS), Accession No. Hs465374(EFHD2), Accession No. Hs 465498(TXNL4A), Accession No. Hs465529(MIDN), Accession No. Hs 465543(BTBD2), Accession No. Hs465627(MAP2K2), Accession No. Hs 465645(C19orf10), Accession No. Hs465808(HNRPM), Accession No. Hs 465849(PIN1), Accession No. Hs465924(SDHB), Accession No. Hs 466044(PKN1), Accession No. Hs466088(TPM4), Accession No. Hs 466148(NR2F6), Accession No. Hs466471(GPI), Accession No. Hs 466693(SIRT2), Accession No. Hs466766(LTBP4), Accession No. Hs 466775(SNRPA), Accession No. Hs467084(EIF4G3), Accession No. Hs 467097(SNRP70), Accession No. Hs467192(PPP2R1A), Accession No. Hs 467279(LENG4), Accession No. Hs467284(RPS9), Accession No. Hs 467408(TRIM28), Accession No. Hs467637(CDC42), Accession No. Hs 467696(HPCAL1), Accession No. Hs467701(ODC1), Accession No. Hs 467807(LAPTM4A), Accession No. Hs467824(PUM2), Accession No. Hs 467960(RAB10), Accession No. Hs468018(PPP1CB), Accession No. Hs 468415(PIGF), Accession No. Hs468442(CALM2), Accession No. Hs 468760(AFTIPHILIN), Accession No. Hs469022(DGUOK), Accession No. Hs 469171(DKFZP564D0478), Accession No. Hs469331(STARD7), Accession No. Hs 469820(RALB), Accession No. Hs469863(YWHAZ), Accession No. Hs 469925(FLJ14346), Accession No. Hs469970(SFRS4), Accession No. Hs 470091(YWHAE), Accession No. Hs470233(ARL5), Accession No. Hs 470417, Accession No. Hs 470477(PTP4A2),Accession No. Hs 470577(EIF2S2), Accession No. Hs 470588(KPNA6),Accession No. Hs 470943(STAT1), Accession No. Hs 471011(SF3B1),Accession No. Hs 471104(NOP5/NOP58), Accession No. Hs 471207(NDUFS1),Accession No. s 471441(PSMB2), Accession No. Hs 471461(ACSL3), AccessionNo. Hs 471593(CAB39), Accession No. Hs 471768(MGC4796), Accession No. Hs471818(M11S1), Accession No. Hs 471851(HDLBP), Accession No. Hs471873(DTYMK), Accession No. Hs 471933(FKBP1A), Accession No. Hs471975(C20orf116), Accession No. Hs 472010(PRNP), Accession No. Hs472024(C20orf30), Accession No. Hs 472031(UBE2D3), Accession No. Hs472038(CGI-94), Accession No. Hs 472056(SYNCRIP), Accession No. Hs472119(MKKS), Accession No. Hs 472185(NDUFS5), Accession No. Hs472213(RRBP1), Accession No. Hs 472330(C20orf3), Accession No. Hs472475(MACF1), Accession No. Hs 472535(AKIP), Accession No. Hs472558(SDBCAG84), Accession No. Hs 472651(BLCAP), Accession No. Hs472737(TOP1), Accession No. Hs 473296(TPD52L2), Accession No. Hs473583(NSEP1), Accession No. Hs 473648(GART), Accession No. Hs473721(SLC2A1), Accession No. Hs 473761(RTN3), Accession No. Hs473788(OTUB1), Accession No. Hs 474005(SUMO3), Accession No. Hs474010(PTTG1IP), Accession No. Hs 474053(COL6A1), Accession No. Hs474083(B4GALT2), Accession No. Hs 474213(UFD1L), Accession No. Hs474584(AKR1A1), Accession No. Hs 474643(HSPC117), Accession No. Hs474751(MYH9), Accession No. Hs 474833(CSNK1E), Accession No. Hs474914(RUTBC3), Accession No. Hs 474938(SLC25A17), Accession No. Hs474949(RBX1), Accession No. Hs 474982(ACO2), Accession No. Hs475125(ATXN10), Accession No. Hs 475319(LRRFIP2), Accession No. Hs475382(FLJ122405), Accession No. Hs 475392(L0055831), Accession No. Hs475663(RAB5A), Accession No. Hs 475733(TOP2B), Accession No. Hs475812(SIMP), Accession No. Hs 476018(CTNNB1), Accession No. Hs476033(TLP19), Accession No. Hs 476179(SMARCC1), Accession No. Hs476221(IHPK2), Accession No. Hs 76231(IMPDH2), Accession No. Hs476308(ALAS1), Accession No. Hs 476365(SCP2), Accession No. Hs476448(FLNB), Accession No. Hs 476706(MRPL37), Accession No. Hs476930(DKFZP564O123), Accession No. Hs 477157(DULLARD), Accession No. Hs477789(ATP1B3), Accession No. Hs 477892(GYG), Accession No. Hs478000(MBNL1), Accession No. Hs 478044(PA2G4), Accession No. Hs478553(EIF4A2), Accession No. Hs 479208(FBXL5), Accession No. Hs479264(LAP3), Accession No. Hs 479634(SLC30A9), Accession No. Hs479693(SFRS11), Accession No. Hs 479728(GAPD), Accession No. Hs479747(BCAR1), Accession No. Hs 479814(POLR2B), Accession No. Hs480073(HNRPD), Accession No. Hs 480311(PDLIM5), Accession No. Hs480465(SCYE1), Accession No. Hs 80653(ANXA5), Accession No. Hs481571(UQCRH), Accession No. Hs 481720(MYO10), Accession No. Hs481898(KAT3), Accession No. Hs 482144(RPL26), Accession No. Hs482363(SLC30A5), Accession No. Hs 482526(TINP1), Accession No. Hs482868(KIAA0372), Accession No. Hs 483036(PJA2), Accession No. Hs483067(C5orf13), Accession No. Hs 483305(HINT1), Accession No. Hs483408(PPP2CA), Accession No. Hs 483454(CNN3), Accession No. Hs483486(JMJD1B), Accession No. Hs 484138(FBXW11), Accession No. Hs484188(ATP6V0E), Accession No. 484242(ETEA), Accession No. Hs484288(DDX41), Accession No. Hs 484363(RNF130), Accession No. Hs484551(CPM), Accession No. Hs 484813(DEK), Accession No. Hs485155(RPL35), Accession No. Hs 485195(SORT1), Accession No. Hs485246(PSMA5), Accession No. Hs 485262(MTCH1), Accession No. Hs485365(AHCYL1), Accession No. Hs 485616(DST), Accession No. Hs486542(BCLAF1), Accession No. Hs 487027(VIL2), Accession No. Hs487054(TCP1), Accession No. Hs 487635(BZW2), Accession No. Hs487774(HNRPA2B1), Accession No. Hs 488171(KIAA1068), Accession No. Hs488181(OGDH), Accession No. Hs 488307(DKFZP564K0822), Accession No. Hs488478(FLJ10099), Accession No. Hs 488671(BAZ1B), Accession No. Hs489207(ASNS), Accession No. Hs 489284(ARPC1B), Accession No. Hs489287(CPSF4), Accession No. Hs 489336(SYAP1), Accession No. Hs489615(PBEF1), Accession No. Hs 490203(CALD1), Accession No. Hs490394(SSBP1), Accession No. Hs 490415(ZYX), Accession No. Hs490745(DNAJB6), Accession No. Hs 490795(CHR2SYT), Accession No. Hs490874(MTX1), Accession No. Hs 491336(ELP3), Accession No. Hs491359(LMNA), Accession No. Hs 491440(PPP2CB), Accession No. Hs491494(CCT3), Accession No. Hs 491597(VDAC3), Accession No. Hs491695(UBE2V2), Accession No. Hs 491745(TCEA1), Accession No. Hs491988(TRAM1), Accession No. Hs 492236(WDR42A), Accession No. Hs492314(LAPTM4B), Accession No. Hs 492445(EDD), Accession No. Hs492599(EIF3S3), Accession No. Hs 492805(CGI-07), Accession No. Hs493362(AK3L1), Accession No. Hs 493750(WDR40A), Accession No. Hs494173(ANXA1), Accession No. Hs 494419(LAMP1), Accession No. Hs494457(NINJ1), Accession No. Hs 494604(ANP32B), Accession No. Hs494614(XTP2), Accession No. Hs 494691(PFN1), Accession No. Hs494700(CDW92), Accession No. Hs 494985(FBXW2), Accession No. Hs495039(NDUFA8), Accession No. Hs 495349(KIAA0515), Accession No. Hs495471(PMPCA), Accession No. Hs 495605(CD99), Accession No. Hs495851(MGC4825), Accession No. Hs 495960(ATP6AP2), Accession No. Hs496068(PCTK1), Accession No. Hs 496098(DKFZp761A052), Accession No. Hs496271, Accession No. Hs 496487(ATF4), Accession No. Hs 496646(IL13RA1),Accession No. Hs 496684(LAMP2), Accession No. Hs 497183(IVNS1ABP),Accession No. Hs 497599(WARS), Accession No. Hs 497692(C1orf48),Accession No. Hs 497893(ENAH), Accession No. Hs 498239(FH), AccessionNo. Hs 498313(ADSS), Accession No. Hs 498317(PNAS-4), Accession No. Hs498455(KIAA0217), Accession No. Hs 498548(RBM17), Accession No. Hs498727(DHCR24), Accession No. Hs 499145(YME1L1), Accession No. Hs499158(GGA1), Accession No. Hs 499594(TIMM23), Accession No. Hs499833(C10orf74), Accession No. Hs 499891(HNRPH3), Accession No. Hs499925(VPS26), Accession No. Hs 499960(SARA1), Accession No. Hs500067(PPP3CB), Accession No. Hs 500101(VCL), Accession No. Hs500375(ENTPD6), Accession No. Hs 500409(GLUD1), Accession No. Hs500546(IDE), Accession No. Hs 500674(SMBP), Accession No. Hs500775(ZNF207), Accession No. Hs 500842(MGEAS), Accession No. Hs500874(CUEDC2), Accession No. Hs 501012(ADD3), Accession No. Hs501023(MXI1), Accession No. Hs 501203(TIAL1), Accession No. Hs501293(BSG), Accession No. Hs 501309(CIRBP), Accession No. Hs501353(PLEKHJ1), Accession No. Hs 501376(UROS), Accession No. Hs501420(NCLN), Accession No. Hs 501629(IER2), Accession No. Hs501684(NAP1L4), Accession No. Hs 501735(STIM1), Accession No. Hs501853(C11orf15), Accession No. Hs 501924(USP47), Accession No. Hs501991(MLSTD2), Accession No. Hs 502302(CAT), Accession No. Hs502328(CD44), Accession No. Hs 502461(DGKZ), Accession No. Hs502528(NDUFS3), Accession No. Hs 502630(C11orf31), Accession No. Hs502659(RHOC), Accession No. Hs 502705(PRP19), Accession No. Hs502745(FADS2), Accession No. Hs 502769(SLC3A2), Accession No. Hs502773(MTCBP-1), Accession No. Hs 502823(PRDX5), Accession No. Hs502829(SF1), Accession No. Hs 502836(ARL2), Accession No. Hs502842(CAPN1), Accession No. Hs 502872(MAP3K11), Accession No. Hs502876(RHOB), Accession No. Hs 503093(ZFP36L2), Accession No. Hs503222(RAB6A), Accession No. Hs 503251(PME-1), Accession No. Hs503597(HSPC148), Accession No. Hs 503709(PORIMIN), Accession No. Hs503716(MGC2714), Accession No. Hs 503787(DARS), Accession No. Hs504237(ITM1), Accession No. Hs 504517(RPS27), Accession No. Hs504613(PTMS), Accession No. Hs 504620(REA), Accession No. Hs504687(MYL9), Accession No. Hs 504828(DDX47), Accession No. Hs504895(STRAP), Accession No. Hs 505033(KRAS2), Accession No. Hs505059(PSMD4), Accession No. Hs 505625(C12orf10), Accession No. Hs505652(COPZ1), Accession No. Hs 505676(CIP29), Accession No. Hs505705(MYL6), Accession No. Hs 505806(PBXIP1), Accession No. Hs505824(CGI-51), Accession No. Hs 506215(RARS), Accession No. Hs506325(NUDT4), Accession No. Hs 06759(ATP2A2), Accession No. Hs506861(DDX54), Accession No. Hs 507074(KIAA0152), Accession No. Hs507162(FLJ12750), Accession No. Hs 507584(MGC9850), Accession No. Hs507680(PFAAP5), Accession No. Hs 507910(PGRMC2), Accession No. Hs507916(TGFB114), Accession No. Hs 508010(FNDC3A), Accession No. Hs508644(FLJ10154), Accession No. Hs 509163(KIAA1181), Accession No. Hs509226(FKBP3), Accession No. Hs 509264(KLHDC2), Accession No. Hs509414(KTN1), Accession No. Hs 509622(RGL2), Accession No. Hs509736(HSPCB), Accession No. Hs 509791(ERH), Accession No. Hs509909(NUMB), Accession No. Hs 510087(ENSA), Accession No. Hs510328(DDX24), Accession No. Hs 510402(MCP), Accession No. Hs511067(FLJ10579), Accession No. Hs 511138(DKFZP564G2022), Accession No.Hs 511149(SNAP23), Accession No. Hs 511425(SRP9), Accession No. Hs511504(TCF12), Accession No. Hs 511862, Accession No. Hs 511952(CBX6),Accession No. Hs 512005(ARPC3), Accession No. Hs 512465(SURF4),Accession No. Hs 512525(RPS17), Accession No. Hs 512607(MIR16),Accession No. Hs 512640(PRKCSH), Accession No. Hs 512661(KIAA1160),Accession No. Hs 512676, Accession No. Hs 512693(FLJ120859), AccessionNo. Hs 512756(THAP7), Accession No. Hs 512815(AP3D1), Accession No. Hs512857(CD151), Accession No. Hs 512867(H63), Accession No. Hs512908(ARPP-19), Accession No. Hs 513043(C15orf12), Accession No. Hs513055(REC14), Accession No. Hs 513057(RANBP5), Accession No. Hs513058(TMED3), Accession No. Hs 513071(MESDC1), Accession No. Hs513083(RPL9), Accession No. Hs 513141(IDH2), Accession No. Hs513145(NEUGRIN), Accession No. Hs 513153(FURIN), Accession No. Hs513230(MRPL28), Accession No. Hs 513242(RHOT2), Accession No. Hs513261(C16orf34), Accession No. Hs 513266(NDUFB10), Accession No. Hs513470(NFATC2IP), Accession No. Hs 513488(MVP), Accession No. Hs513490(ALDOA), Accession No. Hs 513520(BCKDK), Accession No. Hs513522(FUS), Accession No. Hs 513631(ARL2BP), Accession No. Hs513856(DPH2L1), Accession No. Hs 513984(FLII), Accession No. Hs514012(MAP2K3), Accession No. Hs 514036(SDF2), Accession No. Hs514038(FLOT2), Accession No. Hs 514174(JUP), Accession No. Hs514196(RPL27), Accession No. Hs 514211(MGC4251), Accession No. Hs514216(CGI-69), Accession No. Hs 514220(GRN), Accession No. Hs514297(FLJ13855), Accession No. Hs 514303(PHB), Accession No. Hs514435(SF3B3), Accession No. Hs 514489(WBP2), Accession No. Hs514535(LGALS3BP), Accession No. Hs 514581(ACTG1), Accession No. Hs514590(HGS), Accession No. Hs 514819(AP2B1), Accession No. Hs514870(ATP5F1), Accession No. Hs 514920(NDP52), Accession No. Hs514934(CAPZA1), Accession No. Hs 515003(C19orf6), Accession No. Hs515005(STK11), Accession No. Hs 515018(GNA13), Accession No. Hs515053(AES), Accession No. Hs 515070(EEF2), Accession No. Hs515092(CLPP), Accession No. Hs 515155(MGC2803), Accession No. Hs515162(CALR), Accession No. Hs 515164(GADD45GIP1), Accession No. Hs515210(DNAJB1), Accession No. Hs 515255(LSM4), Accession No. Hs515266(RENT1), Accession No. Hs 515271(SFRS14), Accession No. Hs515329(RPL22), Accession No. Hs 515371(CAPNS1), Accession No. Hs515406(AKT2), Accession No. Hs 515417(EGLN2), Accession No. Hs515432(DEDD2), Accession No. Hs 515472(SNRPD2), Accession No. Hs515475(SYMPK), Accession No. Hs 515487(CALM3), Accession No. Hs515494(SLC1A5), Accession No. Hs 515500(SAE1), Accession No. Hs515515(KDELR1), Accession No. Hs 515517(RPL18), Accession No. Hs515524(NUCB1), Accession No. Hs 515540(PTOV1), Accession No. Hs515550(LOC284361), Accession No. Hs 515598(PRPF31), Accession No. Hs515607(PPP1R12C), Accession No. Hs 515642(GPSN2), Accession No. Hs515785(BLVRB), Accession No. Hs 515846(RUVBL2), Accession No. Hs515848(HADHB), Accession No. Hs 515890(YPEL5), Accession No. Hs516075(TIA1), Accession No. Hs 516077(FLJ14668), Accession No. Hs516087(TEX261), Accession No. Hs 516111(DCTN1), Accession No. Hs516114(WBP1), Accession No. Hs 516157(MAT2A), Accession No. Hs516450(FLJ120297), Accession No. Hs 516522(FLJ121919), Accession No. Hs516539(HNRPA3), Accession No. Hs 516587(UBE2Q), Accession No. Hs516633(NCKAP1), Accession No. Hs 516711(CHPF), Accession No. Hs516790(ARHGEF2), Accession No. Hs 516807(STK25), Accession No. Hs516826(TRIB3), Accession No. Hs 516855(CENPB), Accession No. Hs517080(SLC35C2), Accession No. Hs 517106(CEBPB), Accession No. Hs517134(C20orf43), Accession No. Hs 517145(ENO1), Accession No. Hs517168(TAGLN2), Accession No. Hs 517216(PEA15), Accession No. Hs517232(PEX19), Accession No. Hs 517240(IFNGR2), Accession No. Hs517262(SON), Accession No. Hs 517293(FLJ1R), Accession No. Hs517338(ATP6V1E1), Accession No. Hs 17342(DEDD), Accession No. Hs517356(COL18A1), Accession No. Hs 517357(DGCR2), Accession No. Hs517421(PCQAP), Accession No. Hs 517438(ASCC2), Accession No. Hs517517(EP300), Accession No. Hs 517543(PES1), Accession No. Hs517582(MCM5), Accession No. Hs 517622(UNC84B), Accession No. Hs517641(L3MBTL2), Accession No. Hs 517666(DIA1), Accession No. Hs517731(PP2447), Accession No. Hs 517768(DKFZP564B167), Accession No. Hs517792(C3orf10), Accession No. Hs 517817(MGC3222), Accession No. Hs517821, Accession No. Hs 517888(CRTAP), Accession No. Hs 517948(DHX30),Accession No. Hs 517949(MAP4), Accession No. Hs 517969(APEH), AccessionNo. Hs 517981(TUSC2), Accession No. Hs 518060(ARL6IP5), Accession No. Hs518123(TFG), Accession No. Hs 518236(SEC61A1), Accession No. Hs518244(RPN1), Accession No. Hs 518249(ZNF9), Accession No. Hs518250(COPG), Accession No. Hs 518265(H41), Accession No. Hs518326(SERP1), Accession No. Hs 518346(SSR3), Accession No. Hs518374(QSCN6), Accession No. Hs 518424(NDUFB5), Accession No. Hs518460(AP2M1), Accession No. Hs 518464(PSMD2), Accession No. Hs518525(GLUL), Accession No. Hs 518551(RPL31), Accession No. Hs518608(PP784), Accession No. Hs 518609(ARPC5), Accession No. Hs518750(OCIAD1), Accession No. Hs 18805(HMGA1), Accession No. Hs518827(CCNI), Accession No. Hs 519276(MAPKAPK2), Accession No. Hs519304(PELO), Accession No. Hs 519346(ERBB2IP), Accession No. Hs519347(SFRS12), Accession No. Hs 519520(RPS25), Accession No. Hs519523(SERPINB6), Accession No. Hs 519557(TMEM14C), Accession No. Hs519718(TTC1), Accession No. Hs 519756(STK10), Accession No. Hs519818(MGAT1), Accession No. Hs 519909(MARCKS), Accession No. Hs519930(C6orf62), Accession No. Hs 520026(VARS2), Accession No. Hs520028(HSPA1A), Accession No. Hs 520037(NEU1), Accession No. Hs520070(C6orf82), Accession No. Hs 520140(SRF), Accession No. Hs520189(ELOVL5), Accession No. Hs 520205(EIF2AK1), Accession No. Hs520210(KDELR2), Accession No. Hs 520287(C6orf111), Accession No. Hs520313(CD164), Accession No. Hs 520383(STX7), Accession No. Hs520421(PERP), Accession No. Hs 520459(GTF2I), Accession No. Hs520623(C7orf27), Accession No. Hs 520640(ACTB), Accession No. Hs520740(SCRN1), Accession No. Hs 520794(YKT6), Accession No. Hs520898(CTSB), Accession No. Hs 520943(WBSCR1), Accession No. Hs520967(MDH2), Accession No. Hs 520973(HSPB1), Accession No. Hs520974(YWHAG), Accession No. Hs 521064(ZNF655), Accession No. Hs521151(FLJ122301), Accession No. Hs 521289(REPIN1), Accession No. Hs521487(MGC8721), Accession No. Hs 521640(RAD23B), Accession No. Hs521809(COBRA1), Accession No. Hs 521903(LY6E), Accession No. Hs521924(SIAHBP1), Accession No. Hs 521969(NDUFB11), Accession No. Hs521973(WDR13), Accession No. Hs 522074(DSIPI), Accession No. Hs522110(CREB3), Accession No. Hs 522114(CLTA), Accession No. Hs522310(NANS), Accession No. Hs 522373(GSN), Accession No. Hs522394(HSPA5), Accession No. Hs 522463(EEF1A1), Accession No. Hs522507(FBXW5), Accession No. Hs 522584(TMSB4X), Accession No. Hs522590(EIF1AX), Accession No. Hs 522632(TIMP1), Accession No. Hs522665(MAGED2), Accession No. Hs 522675(FLJ12525), Accession No. Hs522752(PSMD10), Accession No. Hs 522817(BCAP31), Accession No. Hs522819(IRAK1), Accession No. Hs 522823(EMD), Accession No. Hs522932(NCOA4), Accession No. Hs 522995(EIF4EBP2), Accession No. Hs523004(PSAP), Accession No. Hs 523012(DDIT4), Accession No. Hs523054(SMP1), Accession No. Hs 523131(TRAPPC3), Accession No. Hs523145(DDOST), Accession No. Hs 523215(NDUFB8), Accession No. Hs523238(NOLC1), Accession No. Hs 523262(C1orf8), Accession No. Hs523299(EIF3S10), Accession No. Hs 523302(PRDX3), Accession No. Hs523560(HSPCA), Accession No. Hs 523680(SSRP1), Accession No. Hs523789(TncRNA), Accession No. Hs 523829(POLD4), Accession No. Hs523836(GSTP1), Accession No. Hs 523852(CCND1), Accession No. Hs523875(INPPL1), Accession No. Hs 524009(AASDHPPT), Accession No. Hs524081(DPAGT1), Accession No. Hs 524084(RNF26), Accession No. Hs524161(RSU1), Accession No. Hs 524171(RAD52), Accession No. Hs524183(FKBP4), Accession No. Hs 524195(ARHGAP21), Accession No. Hs524214(MLF2), Accession No. Hs 524219(TPI1), Accession No. Hs524271(PHC2), Accession No. Hs 524367(CBARA1), Accession No. Hs524395(TUBA3), Accession No. Hs 524464(ATP5G2), Accession No. Hs524502(RNF41), Accession No. Hs 524530(CTDSP2), Accession No. Hs524590(RAB21), Accession No. Hs 524599(NAP1L1), Accession No. Hs524690(PPIE), Accession No. Hs 524788(RAB35), Accession No. Hs524809(RSN), Accession No. Hs 524899(SAP18), Accession No. Hs524920(ZFP91), Accession No. Hs 524969(Ufm1), Accession No. Hs525134(FLJ120277), Accession No. Hs 525163(ANKRD10), Accession No. Hs525232(LRP10), Accession No. Hs 525238(C14orf119), Accession No. Hs525330(ARF6), Accession No. Hs 525391(FLJ120580), Accession No. Hs525527(RER1), Accession No. Hs 525626(PACS1L), Accession No. Hs525899(C6orf49), Accession No. Hs 526464(PML), Accession No. Hs526521(MDH1), Accession No. Hs 527105(HNRPDL), Accession No. Hs527193(RPS23), Accession No. Hs 527348(AKAP9), Accession No. Hs527412(ASAH1), Accession No. Hs 527861(OS-9), Accession No. Hs527862(PKD1), Accession No. Hs 527980(DUT), Accession No. Hs528050(HARS), Accession No. Hs 528222(NDUFS4), Accession No. Hs528300(PITRM1), Accession No. Hs 528305(DDX17), Accession No. Hs528572(SCAM-1), Accession No. Hs 528668(RPL6), Accession No. Hs528780(GSPT1), Accession No. Hs 528803(UQCRC2), Accession No. Hs529059(EIF3S4), Accession No. Hs 529132(SEPW1), Accession No. Hs529244(NCK2), Accession No. Hs 529280(ANAPC7), Accession No. Hs529303(ARPC2), Accession No. Hs 529369(AFAP), Accession No. Hs529400(IFNAR1), Accession No. Hs 529420(UBE2G2), Accession No. Hs529591(TLOC1), Accession No. Hs 529618(TFRC), Accession No. Hs529631(RPL35A), Accession No. Hs 529782(VCP), Accession No. Hs529798(BTF3), Accession No. Hs 529862(CSNK1A1), Accession No. Hs529890(CANX), Accession No. Hs 529892(SQSTM1), Accession No. Hs529957(SEC63), Accession No. Hs 530096(EIF3S2), Accession No. Hs530118(LUC7L2), Accession No. Hs 530291(ANXA11), Accession No. Hs530314(SSNA1), Accession No. Hs 530331(PDHA1), Accession No. Hs530381(PIM3), Accession No. Hs 530412(PAI-RBP1), Accession No. Hs530436(STXBP3), Accession No. Hs 530479(PMF1), Accession No. Hs530687(RNH), Accession No. Hs 530734(MRPL16), Accession No. Hs530753(FLJ120625), Accession No. Hs 530823(COPS7A), Accession No. Hs530862(PRKAG1), Accession No. Hs 531081(LGALS3), Accession No. Hs531089(PSMA3), Accession No. Hs 531176(SARS), Accession No. Hs531330(CBWD1), Accession No. Hs 531614(BTBD14B), Accession No. Hs531752(RANBP3), Accession No. Hs 531856(GAS5), Accession No. Hs531876(DNCL2A), Accession No. Hs 531879(RAD1), Accession No. Hs532359(RPL5), Accession No. Hs 532399(KIAA0663), Accession No. Hs532755(GTL3), Accession No. Hs 532790(NMT1), Accession No. Hs532793(KPNB1), Accession No. Hs 532803(HN1), Accession No. Hs532826(MCL1), Accession No. Hs 532853(NDUFB7), Accession No. Hs533030(HRIHFB2122), Accession No. Hs 533059(TUBB), Accession No. Hs533122(SFRS10), Accession No. Hs 533136(LRPAP1), Accession No. Hs533192(TOMM20), Accession No. Hs 533222(HSA9761), Accession No. Hs533245(DDX46), Accession No. Hs 533282(NONO), Accession No. Hs533308(PPP2R5D), Accession No. Hs 533317(VIM), Accession No. Hs533437(TCEB1), Accession No. Hs 533440(WWP1), Accession No. Hs533474(PPP1R8), Accession No. Hs 533479(LYPLA2), Accession No. Hs533526(ATRX), Accession No. Hs 533624(H3F3A), Accession No. Hs533712(RBM4), Accession No. Hs 533732(SRP14), Accession No. Hs533771(STUB1), Accession No. Hs 533782(KRT8), Accession No. Hs533977(TXNIP), Accession No. Hs 533985(EXOC7), Accession No. Hs533986(ZNF258), Accession No. Hs 534125(HLA-C), Accession No. Hs534168(NDUFA1), Accession No. Hs 534212(SEC22L1), Accession No. Hs534255(B2M), Accession No. Hs 534307(CCND3), Accession No. Hs534314(EIF5A), Accession No. Hs 534326(ITGB4BP), Accession No. Hs534338(PPP4C), Accession No. Hs 534346(RPS7), Accession No. Hs534350(SMARCB1), Accession No. Hs 534453(GRIM19), Accession No. Hs534456(ANAPC11), Accession No. Hs 534457(C14orf166), Accession No. Hs534473(TOMM22), Accession No. Hs 534483(MGC2941), Accession No. Hs536275(PACS1), Accession No. Hs 541269(NDUFB9), Accession No. Hs546248(CTSD), Accession No. Hs 546250(DNCI2), Accession No. Hs546253(FDFT1), Accession No. Hs 546261(HNRPA1), Accession No. Hs546269(RPL10A), Accession No. Hs 546271(PCBP2), Accession No. Hs546286(RPS3), Accession No. Hs 546289(RPS12), Accession No. Hs546290(RPS18), Accession No. Hs 546291(NET-5), Accession No. Hs546339(SMAP), Accession No. Hs 546356(RPL13A), Accession No. Hs546394(HSPC016), Accession No. Hs 547759(SSBP3), Accession No. Hs549178(C9orf86), Accession No. Hs 552590(HTF9C), Accession No. Hs553496(PGM3), Accession No. Hs 553512(C3F), Accession No. Hs554767(NUP88), Accession No. Hs 554776(SREBF1), Accession No. Hs554894(FLJ12953), Accession No. Hs 554896(MGC11257), Accession No. Hs555194(FAM36A), Accession No. Hs 555866(C1QBP), Accession No. Hs555873(HNRPAB), Accession No. Hs 555875(IDH3A), Accession No. Hs555889(PSMC2), Accession No. Hs 555890(RBBP4), Accession No. Hs555911(RBM8A), Accession No. Hs 555969(RIC8), Accession No. Hs555971(PP1201), Accession No. Hs 555973(MRPS25), Accession No. Hs555994(LONP), Accession No. Hs 556267(FBXL10), Accession No. Hs556461(NDUFV2), Accession No. Hs 556795(PAIC5), Accession No. Hs557550(NPM1), Accession No. Hs 558296(ACP1), Accession No. Hs558313(COX6A1), Accession No. Hs 558322(EEF1B2), Accession No. Hs558325(EIF5), Accession No. Hs 558328(FKBP5), Accession No. Hs558330(FTL), Accession No. Hs 558338(HSPE1), Accession No. Hs558345(1K), Accession No. Hs 558354(LAMR1), Accession No. Hs558360(NDUFB4), Accession No. Hs 558361(NME2), Accession No. Hs558362(NUMA1), Accession No. Hs 558376(RAC1), Accession No. Hs558381(RNU65), Accession No. Hs 558382(RPL15), Accession No. Hs558383(RPL18A), Accession No. Hs 558384(RPL19), Accession No. Hs558385(RPL23A), Accession No. Hs 558386(RPL34), Accession No. Hs558388(RPS3A), Accession No. Hs 558389(RPS8), Accession No. Hs558390(RPS24), Accession No. Hs 558391(RPS26), Accession No. Hs558396(SCD), Accession No. Hs 558424(CSDA), Accession No. Hs558426(EIF3S5), Accession No. Hs 558429(G10), Accession No. Hs558431(RPL14), Accession No. Hs 558442(PDCD6IP), Accession No. Hs558448(TXNL2), Accession No. Hs 558453(ATP5L), Accession No. Hs558454(NUDC), Accession No. Hs 558458(COPS8), Accession No. Hs558473(C18orf10), Accession No. Hs 558499(8D6A), Accession No. Hs558511(PSARL), Accession No. Hs 558521(C2orf33), Accession No. Hs558591(ORMDL1), Accession No. Hs 558825(PDE4DIP), Accession No. Hs558995, Accession No. Hs 567260(CD2BP2), Accession No. Hs567263(C1orf43), Accession No. Hs 567267(ATP2C1) and Accession No. Hs567279(HCNGP). According to the present invention, the detection reagentis a pair of primers and/or probes applicable to the amplification ofthe candidate reference gene.

Suitable for use in the composition of the present invention is a pairof a sense primer and an antisense primer, both ranging in length from10 to 50 bp, corresponding to a sense or antisense sequence of theselected candidate reference gene, respectively. The sense primer ispreferably 12-30 bp, more preferably 15-26 bp, and most preferably 17-22bp in length. This is also true of the antisense primer. However, aslong as they are useful in the amplification of the gene, the primersused in the present invention can be any length. The primers may bedesigned using a well-known primer design program. Additionally, theprimers are not limited as to their position on the gene, as long asthey can be used in the amplification of the gene.

In contrast to previously reported traditional HKGs, in which genesencoding metabolism and ribosome proteins are contained in highproportions (Eisenberg E & Levanon E Y, Trends Genet 19:362-5, 2003;Hsiao L L et al., Physiol Genomics 7:97-104, 2001), genes encodingproteins involved in protein fate (23%, 308/1318) and cellular transport(21%, 273/1318) are found at a high proportion within the candidate ERGswhen they are classified by FunCat (Functional Classification Catalogue,Version 2.0, Ruepp A et al., Nucleic Acids Res 32:5539-45, 2004) (seeFIG. 2). Further, analysis on the 2,087 genes shows a high frequency ofCpG islands, which is in line with the results of previous reports(Larsen F et al., Genomics 13:1095-107, 1992; Ponger L et al., GenomeRes 11:1854-60, 2001) (see TABLE 1).

Moreover, the genes can be detected using microarray, SAGE (SerialAnalysis of Gene Expression) or qRT-PCR (quantitative real time PCR).Out of the genes, the most abundant transcript was found to come fromEEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10A inHG-U133 microarray (see Table 2).

In addition, the reference genes selected and identified according tothe present invention are adopted as candidate reference genes which maybe useful in the analysis of the genes of interest through thevalidation of expression stability.

In accordance with a further aspect thereof, the present inventionprovides a method for quantifying an expression level of a gene ofinterest, comprising:

1) performing real-time PCR to amplify the gene of interest with a pairof primers and/or probes and then performing real-time PCR to amplifythe candidate endogenous reference gene with the composition; and

2) normalizing the expression level of the gene of interest relative tothat of the candidate endogenous reference gene.

In accordance with still a further aspect thereof, the present inventionprovides a method for selecting guide genes, comprising measuring theselected candidate endogenous reference genes for coefficient ofvariation (CV) and ranking the endogenous reference genes in anascending order of CV.

In an embodiment, the guide genes are expressed in most human bodytissues. The guide genes can be used to normalize expression levels forrelative quantification of gene expression between different samples.The higher the coefficient of variation (CV) is, the more greatly thegene expression varies from one tissue to another.

CVs of the candidate reference genes, selected using the selectionmethod of the present invention, were calculated for each UniGenecluster in the datasets including EST, ShortSAGE, LongSAGE andmicroarray, and the genes were arranged in ascending order of CV. Fromthe candidate ERG were selected the reference genes which were found tobe stably expressed across a wide range of tissues. Out of the 400 genes(corresponding to about 20% of the candidate ERG) which werepreferentially ranked in ascending order of CV from each dataset, 13ERGs common to all four datasets were selected (see FIG. 1 and Table 3).The 13 reference genes are identified as Accession No. Hs500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs242458(SPG21).

In other words, the reference genes are genes that show lower expressionvariations than do the other genes among the 2,087 genes expressed inmost tissues. The reference genes identified according to the presentinvention are expressed in a manner similar to that in which themajority of the intracellular transcripts are expressed at lowabundance.

In an aspect of gene expression level and CV, the 13 reference genesidentified according to the present invention were compared with 13traditional reference genes (see Table 4). In all datasets, six of the13 traditional reference genes showed relatively high mean expressionlevels, while the other traditional reference genes indicated expressionlevels similar to or lower than those of the reference genes of thepresent invention. In terms of both expression level and CV, thetraditional reference genes are generally greater than the endogenousreference genes of the present invention (see FIGS. 6 and 7).

In order to validate the suitability of the 13 genes for referencegenes, they were examined for gene copy number variation with referenceto the Database of Genomic Variants(//projects.tcag.ca/variation/)(seeTable 5). As a result, only OAZ1 and DIMT1L, among the 13 genes of thepresent invention, were found on chromosome regions known for gene copyvariation, whereas many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) ofthe traditional reference genes were located in such chromosome regions.

Furthermore, the quantitative real-time RT-PCR (qRT-PCR) analysis (seeTable 7) of ERG on human tissue samples and cancer cell lines (see Table6) indicated that the 13 novel ERGs were expressed in all 48 samples,including frozen human tissues and cancer cell lines (see FIG. 8). Thenovel 13 ERGs ranged from 19 to 29 in Cp (Crossing Point, the cyclenumber at which fluorescence crosses the background signal upon qRT-PCR)(see FIG. 9). In addition, using geNorm v3.4 software (Vandesompele J etal., Genome Biol 3:RESEARCH0034, 2002) and NormFinder software (AndersenC L et al., Cancer Res 64:5245-50, 2004), ERGs were analyzed forexpression stability according to the following Mathematical Formula 4in consideration of the efficiency of the PCR performed above (see Table8). All of the 13 novel ERGs according to the present invention werefound to show higher expression stability than were the traditional ERGsas calculated by the geNorm and NormFinder programs (see Table 9). InTable 9, lower expression stability values (M by geNorm, S byNormFinder) mean more stable expression.

Relative Expression=(1+E)^(ΔCp)  <Mathematical Formula 4>

-   -   ΔCp=Minimum Cp−Sample Cp;    -   Minimum Cp=lowest Cp value; and    -   E=PCR Efficiency

There was no significant correlation between the M values, which werecalculated with geNorm (M) and CV in microarray and LongSAGE datasets,but significance was found in EST and ShortSAGE datasets. Likewise, asfor the stability values(S), calculated with NormFinder, significantcorrelation was found in EST, ShortSAGE and LongSAGE, but not inmicroarray. Both the M and the S values showed highest agreement with CVin ShortSAGE (see Table 10).

These results indicate that the reference genes identified according tothe present invention are more stably expressed than are the traditionalreference genes.

In consideration of the fact that the majority of intracellulartranscripts are expressed in low abundance (Warrington J A et al.,Physiol Genomics 2(3):143-147, 2000), traditional reference genes,having high expression levels, may not be suitable for use innormalization. A reference gene with an expression level similar to thatof a target gene is recommended, so that the measurement can be done onthe same linear scale (Szabo A et al., Genome Biol 5(8):R59, 2004;RocheAppliedScience Technical Note No. LC 15/2005). Therefore, theendogenous reference genes identified according to the present inventionare believed to be more suitable and widely used because they showrelatively lower expression and lower variability than do thetraditional reference genes (Czechowski T et al., Plant Physiol139(1):5-17, 2005).

In accordance with still another aspect thereof, the present inventionprovides a composition for detecting at least one of the guide genesidentified according to the present invention, comprising a detectionreagent applicable to amplification of the guide gene.

In an embodiment of this aspect, the guide genes feature low expressionlevels, like most low-abundance intracellular transcripts. The guidegene useful in the present invention is one or more genes selected froma group consisting of Accession No. Hs 500775(ZNF207), Accession No. Hs446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs494985(FBXW2) and Accession No. Hs 242458(SPG21). According to thepresent invention, the detection reagent is a pair of primers and/orprobes applicable to the amplification of the guide gene.

Suitable for use in the composition of the present invention is a pairof a sense primer and an antisense primer, both ranging in length from10 to 50 bp corresponding to sense or antisense sequence of theidentified guide genes, respectively. The sense primer is preferably12-30 bp, more preferably 15-26 bp, and most preferably 17-22 bp inlength. This is also true of the antisense primer. However, as long asthey are useful in the amplification of the gene, any length of primerscan be used in the present invention. The primers may be designed usinga well-known primer design program. Additionally, the primers are notlimited by the position on the gene as long as they can be used in theamplification of the gene.

In addition, the detection method is preferably conducted usingmicroarray, SAGE (Serial Analysis of Gene Expression) or qRT-PCR(quantitative real time PCR).

In accordance with yet a further aspect thereof, the present inventionprovides a method for quantifying an expression level of a target gene,comprising:

1) synthesizing cDNA from RNA of a subject;

2) performing real-time PCR to amplify the target gene using a pair ofprimers and/or probes, with the cDNA serving as a template and thenperforming real-time PCR to amplify the candidate endogenous referencegene using the composition; and

2) normalizing the expression level of the target gene to that of thecandidate endogenous reference gene.

In accordance with yet another aspect thereof, the present inventionprovides a method for identifying the amplification of a target gene ingenomic DNA, comprising:

1) amplifying the target gene with a pair of primers or probes throughreal-time PCR, with a genomic DNA of a subject serving as a template andthan performing real-time PCR to amplify the candidate endogenousreference gene with the composition; and

2) normalizing the expression level of the target gene to that of thecandidate endogenous reference gene.

MODE FOR INVENTION

A better understanding of the present invention may be obtained throughthe following examples which are set forth to illustrate, but are not tobe construed as the limit of the present invention.

Example 1: Gene Expression Dataset Construction

EST (expressed sequence tag) and SAGE (serial analysis of geneexpression) human gene expression data were collected from the publiclyavailable CGAP site (The Cancer Genome Project,http://cgap.nci.nih.gov/). Microarray gene expression data were obtainedfrom the GeneExpress Oncology Datasuite™ of Gene Logic Inc., based onthe Affymetrix Human Genome U133 array set.

Out of a total of 8,633 libraries in Hs_LibData.dat (31/Oct/05) file, 77libraries meeting the requirements: 1) non-normalized and 2)>10,000sequences, were included in the EST dataset constructed from the CGAPsite. EST frequency in each library was obtained from Hs_ExprData.dat(31/Oct/05) file. 29 different tissues, including normal and tumorsamples, and 26,117 UniGene clusters were included in these libraries.

SAGE short data for all 280 libraries (Hs_short.frequencies.gz,05/Dec/06), representing 38,290 UniGene clusters, and SAGE long data(Hs_long.frequencies.gz, 05/Dec/06) for 46 libraries, representing21,868 UniGene clusters, were used in creating the dataset for SAGEshort (ShortSAGE) and long (LongSAGE), respectively. Also, SAGE tagswere mapped to UniGene clusters using the files Hs_short.best_gene.gz(05/Dec/06) and Hs_long.best_gene.gz (05/Dec/06). ShortSAGE and LongSAGEcontained information on SAGE expression in 28 and 9 different tissues,including normal and tumor samples, respectively.

Affymetrix GeneChips gene expression data from 567 different samplesrepresenting 13 different tissues including the brain, the breast, thecolon, the esophagus, the kidney, the liver, the lung, the lymph node,the ovary, the pancreas, the prostate, the rectum and the stomach werealso analyzed (Table 11). Affymetrix (CA) HG-U133 and 44,760 differentprobe sets (total 44,928 probe sets) were included in the microarraydataset.

Example 2: Selection of Candidate ERG

Using the datasets constructed in Example 1, expression level wascalculated for UniGene clusters so as to search for housekeeping geneswhich are constitutively expressed in most human tissues.

Gene expression levels of EST dataset for each gene were calculated asthe number of ESTs of a gene in a given library, divided by the totalnumber of ESTs in all genes in a given library and then multiplied by1,000,000, as expressed by Mathematical Formula 1.

Likewise, Gene expression levels of SAGE dataset for each gene werecalculated as the number of tags (sum of tag frequency) of a gene in agiven library, divided by the total number of tags and then multipliedby 1,000,000, as expressed by Mathematical Formula 2.

$\begin{matrix}{{{ETS}\mspace{14mu} {gene}\mspace{14mu} {expression}} = {\frac{\begin{matrix}{{No}\mspace{14mu} {of}\mspace{14mu} {EST}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}} \\{{Gene}\mspace{14mu} {in}\mspace{14mu} {Library}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {ESTs}\mspace{14mu} {in}\mspace{14mu} {Library}} \times 1\text{,}000\text{,}000}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 1} >} \\{{{SAGE}\mspace{14mu} {gene}\mspace{14mu} {expression}} = {\frac{\begin{matrix}{{No}\mspace{14mu} {of}\mspace{14mu} {Tags}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}} \\{{Gene}\mspace{14mu} {in}\mspace{14mu} {Library}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {Tags}\mspace{14mu} {in}\mspace{14mu} {Library}} \times 1\text{,}000\text{,}000}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 2} >}\end{matrix}$

Expression levels in Microarray dataset were represented by the signalintensity calculated for each transcript by the analysis algorithm ofAffymetrix Microarray Suite 5.0. Mean gene expression was defined as theaverage of gene expression level of a given gene in all libraries.

HKGs for use in identifying endogenous reference genes, which areexpressed in most human tissues, were investigated using EST and SAGEdatasets. In order to examine whether a given gene might be an HKG whichis constitutively expressed across a wide range of tissues, theproportion of the tissues not expressing the given gene to the totaltissues of the EST and SAGE datasets was calculated. If gene expressionfrequency is found in any one library of multiple librariescorresponding to one tissue, that gene was considered to be expressed inthat tissue. For this, the 0's proportion, which is defined as the ratioof the number of the tissues in which a given gene was not expressed tothe total number of tissues, was introduced. In the 0's proportion, “0”indicates that the gene is expressed in all tissues, and conversely, “1”means that the gene is not expressed in any tissue.

$\begin{matrix}{{{0'}s\mspace{14mu} {Proportion}} = \frac{\begin{matrix}{{{No}.\mspace{14mu} {of}}\mspace{14mu} {Tissues}\mspace{14mu} {with}\mspace{14mu} {No}} \\{{Expression}\mspace{14mu} {of}\mspace{14mu} a\mspace{14mu} {Given}\mspace{14mu} {Gene}}\end{matrix}}{{Total}\mspace{14mu} {{No}.\mspace{14mu} {of}}\mspace{14mu} {Tissues}}} & {< {{Mathematical}\mspace{14mu} {Formula}\mspace{14mu} 3} >}\end{matrix}$

In a study of 101 samples obtained from 47 different human tissues andcell lines, cutoff values for the 0's proportion were determined in eachof EST and SAGE datasets so as to include most of the 575 housekeepinggenes identified from previous microarray data using the Affymetrix U95Achip (CA), containing 2,600 probes (Eisenberg E and Levanon E Y, TrendsGenet, 19(7), 362-365, 2003). Genes with 0's proportion<0.4 for EST(EST, 4,027 UniGene clusters), 0.1 for ShortSAGE (4,758 UniGeneclusters) and 0.3 for LongSAGE (4,569 UniGene clusters) were sorted.2,087 genes common to the three datasets were selected

Out of the 575 genes obtained by U95A, 451(78.43%) in EST, 432(75.13%)in ShortSAGE, and 446(77.57%) in LongSAGE were included in the selectedhousekeeping genes, respectively. A majority of the 575 HKGs was foundto have low 0's proportion in the constructed datasets, EST, ShortSAGEand LongSAGE even though some genes showed the 0's proportion greaterthan 0.5 unexpectedly. Traditional reference genes like RPLP0, ACTB,PPIA, GAPDH, PGK1, B2M and were TFRC also found in the 2,087 genes.

The mean gene expression value and CV (%) of the housekeeping genesselected from the EST and SAGE datasets were calculated in themicroarray dataset (Affymetrix HG-U133, CA). The microarray expressiondata of 5,238 different probe sets (gene expression data for 5,317fragments, 1,990 UniGene clusters) corresponding to the selected HKGswere obtained.

UniGene clusters were used to allow respective gene probes to correspondthereto in the datasets. On the chip set HG-U133 were found cases wheremultiple probe sets, which show various expression intensities,correspond to one gene or UniGene cluster. In such cases, one probe setfor one UniGene cluster, showing the lowest CV among several probe sets,was selected.

The 2,087 HKGs obtained above were categorized as “candidate ERGs” or“candidate reference genes” in accordance with the present invention.

Experimental Example 1: Analysis of Candidate ERG

<1-1> Functional Classification of Candidate ERG

Using FunCat (Functional Classification Catalogue, Version 2.0, Ruepp,A., et al. Nucleic Acids Res, 32, 5539-45, 2004), the 2,087 genesobtained above were classified.

Out of the 2,087 candidate ERGs, 1,689 UniGene clusters were associatedwith GO terms allocated to MIPS (Munich Information Center for ProteinSequences) FunCat (Functional Catalogue). Among the 1,689 UniGeneclusters, 1,318 UniGene clusters were functionally classified to beassociated with GO terms corresponding to biological processes. These1,318 genes were identified to be involved in various basic cellularfunctions. While a high proportion of the previously reportedtraditional HKGs encode metabolism and ribosome proteins (Eisenberg E &Levanon E Y, Trends Genet 19:362-5, 2003; Hsiao L L et al., PhysiolGenomics 7:97-104, 2001), genes encoding proteins involved in proteinfate (23%, 308/1318) and cellular transport (21%, 273/1318) are found inlarge amounts in the candidate ERGs (FIG. 2).

<1-2> Analysis of Candidate ERGs for CpG Island

Sequences upstream of the annotated transcription start site of the ERGsaccording to the present invention were obtained from the UCSC site(//hgdownload.cse.ucsc.edu/goldenPath/hg18/bigZips/). CpG islandslocated 1,000, 2,000 and 5,000 bp upstream of the transcription startpoints on the basis of a DNA sequence longer than 500 bp, and having aG+C content of 55% and a CpG observed/expected ratio of 0.65 (Takai D &Jones P A Proc Natl Acad Sci USA, 99, 3740-5, 2002), were searched forusing CpGIE software (Wang, Y & Leung, F C Bioinformatics, 20, 1170-7,2004).

The Z-test (R program, //www.R-project.org) was applied to assesswhether there was a statistical significance of differences in thefrequency of genes with CpG island between the candidate ERGs andnon-candidate ERGs. P<0.05 was considered to be significant.

In line with the previous reports (Larsen, F., et al., Genomics, 13,1095-107. 1992; Ponger, L., et al., Genome Res, 11, 1854-60. 42, 2001),most candidate ERGs were found to show high frequencies of CpG islandsin upstream sequences (1000 bp; 70%, 2000 bp; 73%, 5000 bp; 76%). Incontrast, CpG islands were found at low frequencies in the upstreamsequences of non-candidate ERGs (p<0.001, Table 1).

TABLE 1 Comparison of the Proportion of Genes with CpG Islands inUpstream Sequences of the transcription start site in Candidate ERG andNon-Candidate ERG Candidate ERG Non-Candidate ERG (No. = 2002) (No. =14848) Ratios of Ratios of Upstream No. of Genes with No. of Genes withBp Genes CpG Islands Genes CpG Islands p-values 5000 1516 76% 8036 54%<0.001 2000 1456 73% 7410 50% <0.001 1000 1410 70% 7048 47% <0.001

Experimental Example 2: Correlation Analysis

Correlation analysis was performed using a correlation coefficient,which indicates linear association between two groups, with asignificance level of p<0.05. All calculations and scatter plots wereproduced with the statistical analysis program R-Package(//www.r-project.org).

First, Pearson and Spearman's rank correlation analysis were performedto compare the candidate ERGs selected from the four datasets in termsof gene expression and CV. FIG. 3 is a scatter plot of gene expressionfor the four datasets of the candidate ERGs. It was observed that therewas a significant correlation of expression values between all fourdatasets. ShortSAGE versus LongSAGE showed the highest Spearmancorrelation coefficient of 0.853 (p<0.0001) and the lowest Spearmancorrelation of 0.339 between EST and Microarray (p<0.0001).

Next, the coefficient of variation (CV, %) was computed to investigatethe consistency of the expression level of the candidate ERGs acrossvarious libraries in each dataset. Pearson and Spearman's rankcorrelation analyses were performed on the CV thus obtained, indicatingthat the CV was less similar between datasets (Spearman correlationcoefficient<0.5) than was the gene expression level although asignificant correlation was still found (p≦0.001)(FIG. 4).

These results may be attributed to the difference in the kind and numberof samples between datasets because expression levels may vary dependingon the kind and number of the samples.

Experimental Example 3: Comparison Between Candidate ERG andNon-Candidate ERG

A t-test was conducted to examine whether there was a significantdifference in mean gene expression between candidate ERG andnon-candidate ERG. FIG. 5 shows the distribution of the gene expressionsof candidate ERG and non-candidate ERG for each dataset. As wasexpected, the mean gene expression level of the candidate ERGs wassignificantly higher than that of non-candidate ERGs in all fourdatasets (p<0.0001). These results are in line with previous reports(Eisenberg E and Levanon E Y, Trends Genet, 19(7), 362-365, 2003).

Gene expression levels were found to range from 73.83 to 9324.87 in EST,from 28.58 to 4086.25 in ShortSAGE, from 17.47 to 4621.60 in LongSAGE,and from 1.47 to 18598.26 in HG-U133 microarray. A significant number ofgenes encoding ribosomal proteins showed the highest expression levelsin all four datasets. The most abundant transcript was found to comefrom EEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10Ain HG-U133 microarray (Table 2)

TABLE 2 A list of 2087 candidate endogenous reference genes UniGene ESTcluster Symbol Gene Names Mean CV 0's P 120 PRDX6 Peroxiredoxin 6 458.61113.71 0.034 142 SULT1A1 Sulfotransferase family, cytosolic, 1A,phenol-preferring, member 1248.16 105.30 0.241 202 TSPO translocatorprotein 198.55 80.83 0.207 429 ATP5G3 ATP synthase, H+ transporting,mitochondrial F0 complex, subuni 211.73 76.87 0.103 c (subunit 9)isoform 3 695 CSTB Cystatin B (stefin B) 138.20 109.45 0.345 808 HNRPFHeterogeneous nuclear ribonucleoprotein F 340.14 74.87 0.034 861 MAPK3Mitogen-activated protein kinase 3 145.68 106.68 0.241 1063 SNRPC Smallnuclear ribonucleoprotein polypepticte C 171.26 77.26 0.276 1103 TGFB1Transforming growth factor, beta 1 (Camurati-Engelmann disease) 197.32110.45 0.345 2430 VPS72 Vacuolar protein sorting 72 homolog (S.cerevisiae) 117.28 76.90 0.241 2533 ALDH9A1 Aldehyde dehydrogenase 9family, member A1 119.81 68.68 0.207 2795 LDHA Lactate dehydrogenase A723.58 109.92 0.034 2853 PCBP1 Poly(rC) binding protein 1 203.55 81.020.103 3100 KARS Lysyl-tRNA synthetase 242.90 76.66 0.138 3254 MRPL23Mitochondrial ribosomal protein L23 105.59 58.85 0.379 3353 G3BP1 GTPaseactivating protein (SH3 domain) binding protein 1 221.63 105.29 0.1383416 ADFP Adipose differentiation-related protein 250.88 167.90 0.2413439 STOML2 Stomatin (EPB72)-like 2 303.44 78.37 0.069 3530 FUSIP1 FUSinteracting protein (serine/arginine-rich) 1 188.96 77.05 0.138 3989PLXNB2 Plexin B2 365.44 108.04 0.138 4055 KLF6 Kruppel-like factor 6258.77 121.39 0.276 4742 GPAA1 GPAA1P anchor attachment protein 1homolog (yeast) 334.17 107.33 0.207 4747 DKC1 Dyskeratosis congenita 1,dyskerin 232.08 109.39 0.138 4766 FAM32A Family with sequence similarity32, member A 182.68 72.56 0.138 4859 CCNL1 Cyclin L1 117.20 67.94 0.3794997 RBM23 RHA binding motif protein 23 151.36 66.00 0.345 4998 TMOD3Tropomodulin 3 (ubiquitous) 117.77 105.21 0.345 5062 TSPAN3 Tetraspanin3 230.30 90.95 0.069 5086 RBM42 RNA binding motif protein 42 232.3280.47 0.172 5120 DYNLL1 Dynein, light chain, LC8-type 1 202.21 103.080.103 5158 ILK Integrin-linked kinase-2 154.41 64.84 0.138 5245 PIH1D1PIH1 domain containing 1 300.56 124.75 0.207 5258 MAGED1 Melanomaantigen family D, 1 605.46 103.33 0.138 5268 ZDHHC4 Zinc finger,DHHC-type containing 4 105.02 62.27 0.345 5298 ADIPOR1 Adiponectinreceptor 1 175.47 95.76 0.138 5308 UBA52 Ubiquitin A-52 residueribosomal protein fusion product 1 482.46 229.44 0.103 5324 C2orf25Chromosome 2 open reading frame 25 665.12 222.84 0.138 5345 RNPEPL1Arginyl aminopeptidase (aminopeptidase B)-like 1 174.04 85.31 0.310 5662GNB2L1 Guanine nucleotide binding protein (G protein), beta polypeptide2 2888.02 78.73 0.000 like 1 5710 CREG1 Cellular repressor ofE1A-stimulated genes 1 186.09 125.07 0.241 5719 NCAPD2 Non-SMC condensinI complex, subunit D2 285.44 132.20 0.241 5912 FBXO7 F-box protein 7203.36 91.84 0.207 5947 RAB8A RAB8A, member RAS oncogene family 195.7670.42 0.138 6396 JTB Jumping translocation breakpoint 264.77 96.40 0.1726454 GIPC1 GIPC PDZ domain containing family, member 1 283.16 100.250.069 6459 GPR172A G protein-coupled receptor 172A 180.95 83.98 0.2766551 ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1238.13 103.93 0.207 6891 SFRS6 Splicing factor, arginine/serine-rich 6131.50 89.49 0.241 7101 ANAPC5 Anaphase promoting complex subunit 5248.20 68.36 0.103 7236 NOSIP Nitric oxide synthase interacting protein160.80 86.71 0.310 7476 ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c″ 179.43 84.77 0.241 7527 REXO2 REX2, RNA exonuclease 2homolog (S. cerevisiae) 137.24 85.72 0.379 7744 NDUFV1 NADHdehydrogenase (ubiquinone) flavoprotein 1, 51 kDa 373.45 70.69 0.0697753 CALU Calumenin 251.14 83.95 0.069 7768 FIBP Fibroblast growthfactor (acidic) intracellular binding protein 149.44 71.07 0.138 7862PNRC2 Proline-rich nuclear receptor coactivator 2 165.82 66.37 0.2417910 RYBP RING1 and YY1 binding protein 148.78 147.82 0.310 7917 HIGD1AHIG1 domain family, member 1A 1039.59 201.55 0.103 8102 RPS20 Ribosomalprotein S20 808.74 200.51 0.000 8372 UQCR Ubiquinol-cytochrome creductase, 6.4 kDa subunit 171.69 131.04 0.172 8737 WDR6 WD repeatdomain 6 214.98 113.65 0.172 8752 TMEM4 Transmembrane protein 4 133.3983.23 0.345 8765 DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 139.5172.23 0.310 8859 CANT1 Calcium activated nucleotidase 1 195.72 80.270.310 8867 CYR61 Cysteine-rich, angiogenic inducer, 61 267.57 79.910.379 9003 C16orf58 Chromosome 16 open reading frame 58 148.64 68.890.207 9015 LOC57255 Hypothetical locus LOC572558 130.09 98.43 0.276 9043NGDN Neuroguidin, EIF4E binding protein 117.81 54.04 0.379 9234 TMEM147Transmembrane protein 147 129.58 83.82 0.207 9235 NME4 Protein expressedin non-metastatic cells 4 148.59 103.05 0.379 9527 C2orf28 Chromosome 2open reading frame 28 184.04 88.83 0.207 9534 SEC11A SEC11 homolog A (S.cerevisiae) 146.99 82.65 0.069 9573 ABCF1 ATP-binding cassette,sub-family F (GCN20), member 1 173.73 124.13 0.276 9589 UBQLN1 Ubiquilin1 111.34 60.19 0.310 9788 NDFIP1 Nedd4 family interacting protein 1167.04 73.62 0.172 9825 FAM96B Family with sequence similarity 96,member B 139.95 94.16 0.345 9857 DCXR Dicarbonyl/L-xylulose reductase170.77 74.16 0.379 10326 COPE Coatomer protein complex, subunit epsilon383.31 95.38 0.103 10842 RAN RAN, member RAS oncogene family 825.5682.38 0.000 10848 BMS1 BMS1 homolog, ribosome assembly protein (yeast)121.69 60.27 0.345 11125 SPCS1 Signal peptidase complex subunit 1homolog (S. cerevisiae) 151.97 92.91 0.276 11184 UBE2R2Ubiquitin-conjugating enzyme E2R 2 379.09 474.01 0.172 11223 IDH1Isocitrate dehydrogenase 1 (NADP+), soluble 199.04 77.27 0.103 11355TMPO Thymopoietin 213.98 130.12 0.172 11463 CMPK Cytidylate kinase180.54 86.53 0.172 12013 ABCE1 ATP-binding cassette, sub-family E(OABP), member 1 179.59 72.05 0.241 12084 TUFM Tu translation elongationfactor, mitochondrial 518.02 95.08 0.207 12102 SNX3 Sorting nexin 3280.04 91.18 0.207 12107 CHMP2A Chromatin modifying protein 2A 108.7744.44 0.207 12109 CIAO1 Cytosolic iron-sulfur protein assembly 1 homolog(S. cerevisiae) 127.53 69.27 0.207 12144 KIAA1033 KIAA1033 109.38 59.100.345 12152 SRPRB Signal recognition particle receptor, B subunit 197.29199.04 0.310 12272 BECN1 Beclin 1 (coiled-coil, myosin-like BCL2interacting protein) 135.99 56.22 0.310 12341 ADAR Adenosine deaminase,RNA-specific 272.66 83.29 0.103 12457 NUP133 Nucleoporin 133 kDa 134.39100.25 0.310 12865 NSFL1C NSFL1 (p97) cofactor (p47) 137.86 79.36 0.27613662 TMEM109 Transmembrane protein 109 180.15 110.32 0.276 14317 NOLA3Nucleolar protein family A, member 3 (H/ACA small nucleolar 205.32119.91 0.310 RNPs) 14333 ATPBD1B ATP binding domain 1 family, member B159.24 82.57 0.379 14745 CCNY Cyclin Y 133.37 75.66 0.276 14839 POLR2GPolymerase (RNA) II (DNA directed) polypeptide G 141.30 66.30 0.20714846 SLC7A1 Solute carrier family 7 (cationic amino acid transporter,y+ system 139.07 71.59 0.310 member 1 14894 TGOLN2 Trans-golgi networkprotein 2 157.54 69.37 0.241 15277 C16orf33 Chromosome 16 open readingframe 33 120.09 75.30 0.310 15591 COPS6 COP9 constitutivephotomorphogenic homolog subunit 6 217.83 90.78 0.172 (Arabidopsis)15738 RAB7A RAB7A, member RAS oncogene family 400.18 95.67 0.069 16059CCDC56 Coiled-coil domain containing 56 143.39 86.29 0.345 16130 UBE2OUbiquitin-conjugating enzyme E2O 157.52 114.59 0.241 16349 ASCIZATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein 122.72 69.670.310 17118 C1orf149 Chromosome 1 open reading frame 149 139.92 85.350.310 17250 COQ5 Coenzyme Q5 homolog, methyltransferase (S. cerevisiae)91.88 50.52 0.345 17680 FUCA2 Fucosidase, alpha-L-2, plasma 157.91 93.280.276 17731 CCDC14 Coiled-coil domain containing 14 84.79 48.78 0.37917883 PPM1G Protein phosphatase 1G (formerly 2C), magnesium-dependent,381.13 94.17 0.103 gamma isoform 18069 LGMN Legumain 189.38 150.90 0.31018128 C20orf44 Chromosome 20 open reading frame 44 120.34 63.49 0.27618349 MRPL15 Mitochondrial ribosomal protein L15 126.02 62.29 0.31019673 MAF1 MAF1 homolog (S. cerevisiae) 208.66 72.97 0.069 20013 SYF2SYF2 homolog, RNA splicing factor (S. cerevisiae) 109.39 47.58 0.31020107 KLC1 Kinesin light chain 1 158.65 81.31 0.241 20157 CDK5RAP3 CDK5regulatory subunit associated protein 3 186.17 71.88 0.276 20521 PRMT1Protein arginine methyltransferase 1 270.96 72.70 0.103 20529 FAM79AFamily with sequence similarity 79, member A 101.33 68.50 0.379 20573IGF1R Insulin-like growth factor 1 receptor 133.12 72.84 0.379 20716TIMM17A Translocase of inner mitochondrial membrane 17 homolog A 378.20138.09 0.241 (yeast) 22393 DENR Density-regulated protein 147.59 60.970.138 22543 UBE3A Ubiquitin protein ligase E3A (human papilloma virusE6-associated 180.41 98.42 0.276 protein, Angelman syndrome) 22546CYBASC3 Cytochrome b, ascorbate dependent 3 271.22 114.11 0.276 22616KIAA0664 KIAA0664 protein 126.85 69.83 0.276 23033 UBE2Q2Ubiquitin-conjugating enzyme E2Q (putative) 2 127.34 80.73 0.379 23111FARSA Phenylalanyl-tRNA synthetase, alpha subunit 239.95 79.63 0.24123978 SAFB Scaffold attachment factor B 195.91 87.35 0.207 24301 POLR2EPolymerase (RNA) II (DNA directed) polypeptide E, 25 kDa 345.43 77.040.207 24379 TRAPPC1 Trafficking protein particle complex 1 155.30 123.380.172 24601 FBLN1 Fibulin 1 492.05 242.68 0.345 24950 RGS5 Regulator ofG-protein signalling 5 561.58 225.25 0.345 25155 NET1 Neuroepithelialcell transforming gene 1 114.28 95.82 0.207 25450 SLC29A1 Solute carrierfamily 29 (nucleoside transporters), member 1 201.64 68.32 0.379 25723FAM89B Family with sequence similarity 89, member B 140.19 148.04 0.34526010 PFKP Phosphofructokinase, platelet 268.83 113.15 0.103 26023 FOXJ3Forkhead box J3 73.83 44.60 0.379 26136 PIGY Phosphatidylinositol glycananchor biosynthesis, class Y 150.82 96.10 0.345 26232 MAN2C1Mannosidase, alpha, class 2C, member 1 117.43 87.14 0.379 26403 GSTZ1Glutathione transferase zeta 1 (maleylacetoacetate isomerase) 139.4692.67 0.345 26518 TSPAN4 Tetraspanin 4 164.19 75.89 0.310 27222 NOLA2Nucleolar protein family A, member 2 (H/ACA small nucleolar 172.83107.54 0.276 RNPs) 28491 SAT1 Spermidine/spermine N1-acetyltransferase 1578.08 192.92 0.276 28914 APRT Adenine phosphoribosyltransferase 160.48119.31 0.345 29203 GBL G protein beta subunit-like 172.86 96.17 0.31029665 CLSTN1 Calsyntenin 1 223.34 109.23 0.103 30011 TMEM93Transmembrane protein 93 122.56 80.02 0.379 30026 SSU72 SSU72 RNApolymerase II CTD phosphatase homolog (S. cerevisiae) 122.96 77.31 0.13830345 TRAP1 TNF receptor-associated protein 1 433.73 106.66 0.103 30954PMVK Phosphomevalonate kinase 168.78 141.42 0.379 31053 TBCB Tubulinfolding cofactor B 267.45 128.93 0.276 31334 PRPF6 PRP6 pre-mRNAprocessing factor 6 homolog (S. cerevisiae) 278.00 95.93 0.103 31387C3orf60 Chromosome 3 open reading frame 60 194.85 96.83 0.276 34045CDCA4 Cell division cycle associated 4 142.01 95.48 0.379 34576 TAX1BP1Tax1 (human T-cell leukemia virus type I) binding protein 1 166.29 86.390.138 34906 BLOC1S2 Biogenesis of lysosome-related organelles complex-1,subunit 2 110.24 106.36 0.345 35052 TEGT Testis enhanced gene transcript(BAX inhibitor 1) 601.46 76.56 0.000 35828 MARK3 MAP/microtubuleaffinity-regulating kinase 3 181.74 68.97 0.207 36587 PPP1R7 Proteinphosphatase 1, regulatory subunit 7 147.34 89.65 0.207 36927 HSPH1 Heatshock 105 kDa/110 kDa protein 1 142.61 62.36 0.241 37616 STRA13Stimulated by retinoic acid 13 homolog (mouse) 132.28 87.28 0.310 37916DPP7 Dipeptidylpeptidase 7 189.05 126.98 0.207 42806 SDF4 Stromal cellderived factor 4 395.61 110.02 0.138 43297 MTPN Myotrophin 224.31 82.090.172 47062 POLR2I Polymerase (RNA) II (DNA directed) polypeptide I,14.5 kDa 136.77 76.60 0.310 50098 NDUFA4 NADH dehydrogenase (ubiquinone)1 alpha subcomplex, 4, 9 kDa 444.09 142.87 0.310 50308 HIP2 Huntingtininteracting protein 2 145.77 68.04 0.207 50425 PTGES3 Prostaglandin Esynthase 3 (cytosolic) 411.83 77.96 0.103 53066 HSPBP1 Hsp70-interactingprotein 202.07 92.49 0.138 54277 FAM50A Family with sequence similarity50, member A 145.83 129.34 0.345 54457 CD81 CD81 antigen (target ofantiproliferative antibody 1) 303.19 99.16 0.069 54642 MAT2B Methionineadenosyltransferase II, beta 133.55 71.29 0.207 54649 RY1 Putativenucleic acid binding protein RY-1 203.85 97.67 0.241 55682 EIF3S7Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa455.77 153.84 0.034 55847 MRPL51 Mitochondrial ribosomal protein L51122.64 99.22 0.241 58488 CTNNAL1 Catenin (cadherin-associated protein),alpha-like 1 126.66 70.42 0.379 58992 SMC4 Structural maintenance ofchromosomes 4 228.66 99.66 0.207 59486 HSDL2 Hydroxysteroiddehydrogenase like 2 129.48 73.68 0.345 61812 PTPN12 Protein tyrosinephosphatase, non-receptor type 12 108.62 74.97 0.345 65234 DDX27 DEAD(Asp-Glu-Ala-Asp) box polypeptide 27 199.19 91.01 0.241 65238 RNF40 Ringfinger protein 40 193.26 81.38 0.172 66048 MAP1S Microtubule-associatedprotein 1S 131.74 79.04 0.276 66915 C22orf16 Chromosome 22 open readingframe 16 135.11 102.77 0.379 68714 SFRS1 Splicing factor,arginine/serine-rich 1 (splicing factor 2, alternate 249.07 79.18 0.103splicing factor) 69293 HEXB Hexosaminidase B (beta polypeptide) 198.57153.59 0.276 69554 RNF126 Ring finger protein 126 161.03 83.35 0.24169855 UNR Cold shock domain containing E1, RNA-binding 657.29 110.510.103 71465 SQLE Squalene epoxidase 105.27 62.62 0.276 71787 MRPS7Mitochondrial ribosomal protein S7 159.90 59.92 0.310 73527 CSNK2BCasein kinase 2, beta polypeptide 202.65 73.01 0.207 73722 APEX1 APEXnuclease (multifunctional DNA repair enzyme) 1 339.50 85.30 0.103 73799GNAI3 Guanine nucleotide binding protein (G protein), alpha inhibiting150.46 62.95 0.207 activity polypeptide 3 73965 SFRS2 Hypotheticalprotein ET 280.26 73.78 0.000 74047 ETFB Electron-transfer-flavoprotein,beta polypeptide 168.06 80.53 0.138 74050 FVT1 Follicular lymphomavariant translocation 1 98.29 70.32 0.379 74137 TMED10 Transmembraneemp24-like trafficking protein 10 (yeast) 237.09 91.81 0.138 74375 DVL1Dishevelled, dsh homolog 1 (Drosophila) 133.54 77.04 0.276 74405 YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase 413.13 88.00 0.034activation protein, theta polypeptide 74471 GJA1 Gap junction protein,alpha 1, 43 kDa (connexin 43) 183.35 62.77 0.379 74563 OAZ2 Ornithinedecarboxylase antizyme 2 193.33 73.23 0.103 74564 SSR2 Signal sequencereceptor, beta (translocon-associated protein 312.91 86.38 0.034 beta)74576 GDI1 GDP dissociation inhibitor 1 230.50 117.59 0.138 75056 TIMM13Translocase of inner mitochondrial membrane 13 homolog (yeast) 225.2576.11 0.345 75061 MARCKSL MARCKS-like 1 449.23 89.23 0.103 75066 TSNTranslin 128.46 75.98 0.345 75087 FASTK Fas-activated serine/threoninekinase 179.08 68.42 0.345 75117 ILF2 Interleukin enhancer binding factor2, 45 kDa 349.26 76.78 0.034 75133 TFAM Transcription factor A,mitochondrial 111.21 68.59 0.310 75139 ARFIP2 ADP-ribosylation factorinteracting protein 2 (arfaptin 2) 178.80 116.43 0.345 75189 DAPDeath-associated protein 217.73 94.24 0.103 75227 NDUFA9 NADHdehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 290.29 122.15 0.13875243 BRD2 Bromodomain containing 2 301.76 102.55 0.069 75249 ARL6IP1ADP-ribosylation factor-like 6 interacting protein 1 269.13 69.42 0.17275254 IRF3 Interferon regulatory factor 3 131.45 93.03 0.345 75318TUBA4A Tubulin, alpha 4a 346.93 95.88 0.276 75348 PSME1 Proteasome(prosome, macropain) activator subunit 1 (PA28 196.67 85.95 0.138 alpha)75438 QDPR Quinoid dihydropteridine reductase 239.93 101.27 0.345 75527ADSL Adenylosuccinate lyase 187.36 79.69 0.000 75724 COPB2 Coatomerprotein complex, subunit beta 2 (beta prime) 169.19 70.94 0.172 75798C20orf111 Chromosome 20 open reading frame 111 138.12 60.97 0.379 75841ERP29 Endoplasmic reticulum protein 29 170.38 80.11 0.276 75890 MBTPS1Membrane-bound transcription factor peptidase, site 1 143.96 76.79 0.24175914 TMED2 Transmembrane emp24 domain trafficking protein 2 257.3478.55 0.103 76111 DAG1 Dystroglycan 1 (dystrophin-associatedglycoprotein 1) 185.89 66.32 0.310 76394 ECHS1 Enoyl Coenzyme Ahydratase, short chain, 1, mitochondrial 296.18 99.29 0.207 76480 UBL4AUbiquitin-like 4A 177.47 73.71 0.379 76662 ZDHHC16 Zinc finger,DHHC-type containing 16 138.92 90.05 0.276 76686 GPX1 Glutathioneperoxidase 1 154.93 84.27 0.276 76847 GANAB Glucosidase, alpha; neutralAB 371.62 103.22 0.138 77060 PSMB6 Proteasome (prosome, macropain)subunit, beta type, 6 258.61 103.69 0.172 77269 GNAI2 Guanine nucleotidebinding protein (G protein), alpha inhibiting 454.86 93.08 0.103activity polypeptide 2 77313 CDK10 Cyclin-dependent kinase (CDC2-like)10 98.89 72.87 0.345 77422 PLP2 Proteolipid protein 2 (colonicepithelium-enriched) 189.36 121.71 0.310 77558 HMGN3 High mobility groupnucleosomal binding domain 3 161.44 94.74 0.207 77578 USP9X Ubiquitinspecific peptidase 9, X-linked (fat facets-like, Drosophila) 143.3967.26 0.310 77793 CSK C-src tyrosine kinase 222.19 95.17 0.310 77897SF3A3 Splicing factor 3a, subunit 3, 60 kDa 169.65 127.16 0.276 77961HLA-B Major histocompatibility complex, class I, B 851.44 157.10 0.10377978 Hypothetical protein DKFZp761I2123 115.47 65.78 0.345 78466 PSMD8Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 274.96 128.740.241 78601 UROD Uroporphyrinogen decarboxylase 187.65 84.63 0.103 78771PGK1 Phosphoglycerate kinase 1 681.19 86.72 0.034 78880 ILVBL IlvB(bacterial acetolactate synthase)-like 185.37 153.08 0.379 78888 DBIDiazepam binding inhibitor (GABA receptor modulator, acyl- 220.96 127.350.241 Coenzyme A binding protein) 78989 ADH5 Alcohol dehydrogenase 5(class III), chi polypeptide 179.39 72.64 0.034 79064 DHPS Deoxyhypusinesynthase 164.95 100.52 0.241 79081 PPP1CC Protein phosphatase 1,catalytic subunit, gamma isoform 318.25 84.70 0.103 79088 RCN2Reticulocalbin 2, EF-hand calcium binding domain 150.90 75.39 0.20779101 CCNG1 Cyclin G1 240.04 67.65 0.069 79110 NCL Nucleolin 293.0463.35 0.034 79322 QARS Glutaminyl-tRNA synthetase 402.46 67.92 0.13879335 SMARCD1 SWI/SNF related, matrix associated, actin dependentregulator of 146.36 68.95 0.241 chromatin, subfamily d, member 1 79387PSMC5 Proteasome (prosome, macropain) 26S subunit, ATPase, 5 243.7474.96 0.138 79402 POLR2C Polymerase (RNA) II (DNA directed) polypeptideC, 33 kDa 146.42 65.99 0.241 79411 RPA2 Replication protein A2, 32 kDa179.33 111.72 0.345 79625 C20orf149 Chromosome 20 open reading frame 149361.43 94.87 0.310 80545 RPL37 Ribosomal protein L37 755.77 355.66 0.10380919 SYPL1 Synaptophysin-like 1 215.72 101.08 0.207 80986 ATP5G1 ATPsynthase, H+ transporting, mitochondrial F0 complex, subuni 209.65 91.990.276 c (subunit 9), isoform 1 81328 NFKBIA Nuclear factor of kappalight polypeptide gene enhancer in B-cells 186.76 120.33 0.345inhibitor, alpha 81424 SUMO1 SMT3 suppressor of mif two 3 homolog 1(yeast) 313.72 89.00 0.034 81848 RAD21 RAD21 homolog (S. pombe) 368.76164.73 0.103 81964 SEC24C SEC24 related gene family, member C (S.cerevisiae) 186.43 96.07 0.241 82201 CSNK2A2 Casein kinase 2, alphaprime polypeptide 123.76 72.38 0.310 82327 GSS Glutathione synthetase184.39 77.08 0.138 82719 YIPF6 Yip1 domain family, member 6 123.85 72.310.379 82793 PSMB3 Proteasome (prosome, macropain) subunit, beta type, 3158.41 64.83 0.138 82887 PPP1R11 Protein phosphatase 1, regulatory(inhibitor) subunit 11 190.42 75.63 0.241 82890 DAD1 Defender againstcell death 1 202.51 132.00 0.310 82916 CCT6A Chaperonin containing TCP1,subunit 6A (zeta 1) 407.59 75.69 0.034 82927 AMPD2 Adenosinemonophosphate deaminase 2 (isoform L) 148.16 149.07 0.345 83190 FASNFatty acid synthase 562.35 101.57 0.241 83347 AAMP Angio-associated,migratory cell protein 224.46 80.95 0.138 83383 PRDX4 Peroxiredoxin 4152.24 74.89 0.379 83734 STX4 Syntaxin 4 117.13 61.41 0.276 83753 SNRPBSmall nuclear ribonucleoprotein polypeptides B and B1 874.09 87.85 0.13883765 DHFR Dihydrofolate reductase 111.62 78.02 0.310 83916 NDUFA5 NADHdehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13 455.28 149.11 0.20784359 GABARAP GABA(A) receptor-associated protein 190.65 77.34 0.13884753 NT5DC2 5′-nucleotidase domain containing 2 158.64 96.33 0.31085155 ZFP36L1 Zinc finger protein 36, C3H type-like 1 196.81 98.76 0.20785769 DNTTIP2 Deoxynucleotidyltransferase, terminal, interacting protein2 105.55 51.70 0.379 85962 CTF8 Chromosome transmission fidelity factor8 homolog (S. cerevisiae) 170.29 139.62 0.276 86131 FADD Fas(TNFRSF6)-associated via death domain 158.82 101.13 0.172 87752 MSNMoesin 275.46 95.27 0.103 89545 PSMB4 Proteasome (prosome, macropain)subunit, beta type, 4 463.81 87.69 0.034 89643 TKT Transketolase(Wernicke-Korsakoff syndrome) 588.97 97.80 0.103 89649 EPHX1 Epoxidehydrolase 1, microsomal (xenobiotic) 238.26 88.30 0.345 89781 UBTFUpstream binding transcription factor, RNA polymerase I 121.71 54.790.241 89864 SKIV2L Superkiller viralicidic activity 2-like (S.cerevisiae) 132.50 66.99 0.379 90061 PGRMC1 Progesterone receptormembrane component 1 194.16 93.36 0.172 90093 HSPA4 Heat shock 70 kDaprotein 4 149.59 74.25 0.172 90107 ADRM1 Adhesion regulating molecule 1246.89 81.18 0.172 90443 NDUFS8 NADH dehydrogenase (ubiquinone) Fe—Sprotein 8, 23 kDa 153.66 106.13 0.207 (NADH-coenzyme Q reductase) 91142KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)237.57 80.25 0.241 91531 MLLT6 Myeloid/lymphoid or mixed-lineageleukemia (trithorax homolog, 163.44 99.71 0.207 Drosophila);translocated to, 6 93659 PDIA4 Protein disulfide isomerase family A,member 4 221.64 92.23 0.207 93832 TMCO1 Transmembrane and coiled-coildomains 1 215.75 94.44 0.138 95577 CDK4 Cyclin-dependent kinase 4 512.67181.54 0.103 96530 COX11 COX11 homolog, cytochrome c oxidase assemblyprotein (yeast) 133.50 61.61 0.241 96852 EDC3 Enhancer of mRNA decapping3 homolog (S. cerevisiae) 315.49 327.98 0.345 96996 HNRPA0 Heterogeneousnuclear ribonucleoprotein A0 203.93 87.67 0.172 97616 SH3GL1 SH3-domainGRB2-like 1 271.66 106.70 0.069 97887 RCN1 Reticulocalbin 1, EF-handcalcium binding domain 176.05 78.51 0.207 98751 FUBP3 Far upstreamelement (FUSE) binding protein 3 115.91 57.99 0.276 98791 ACTR1B ARP1actin-related protein 1 homolog B, centractin beta (yeast) 154.61 74.840.276 102696 MCTS1 Malignant T cell amplified sequence 1 182.20 108.790.379 102798 PSMA1 Proteasome (prosome, macropain) subunit, alpha type,1 222.80 73.98 0.069 103561 ARL6IP4 ADP-ribosylation-like factor 6interacting protein 4 177.34 82.48 0.172 103834 TMEM106C Transmembraneprotein 106C 164.57 88.83 0.138 104839 TIMP2 TIMP metallopeptidaseinhibitor 2 266.07 83.65 0.172 105547 NPDC1 Neural proliferation,differentiation and control, 1 184.55 89.27 0.345 106185 RALGDS Ralguanine nucleotide dissociation stimulator 113.28 56.31 0.379 106876ATP6V0D1 ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform1 157.31 76.54 0.207 106909 ANAPC13 Anaphase promoting complex subunit13 409.28 124.92 0.310 107003 CCNB1IP1 Cyclin B1 interacting protein 1198.64 135.06 0.207 107101 C1orf86 Chromosome 1 open reading frame 86132.02 90.12 0.310 107387 C7orf20 Chromosome 7 open reading frame 20158.14 146.65 0.379 107393 CLDND1 Claudin domain containing 1 182.6298.17 0.276 108029 SH3BGRL SH3 domain binding glutamic acid-rich proteinlike 217.90 129.37 0.138 108080 CSRP1 Cysteine and glycine-rich protein1 226.87 81.65 0.172 108371 E2F4 E2F transcription factor 4,p107/p130-binding 124.23 53.45 0.207 108408 APH1A Anterior pharynxdefective 1 homolog A (C. elegans) 214.52 73.54 0.276 108957 RPS27LRibosomal protein S27-like 214.43 105.97 0.345 108969 C19orf56Chromosome 19 open reading frame 56 165.48 98.67 0.207 109051 SH3BGRL3SH3 domain binding glutamic acid-rich protein like 3 190.53 95.77 0.207109052 C14orf2 Chromosome 14 open reading frame 2 254.93 147.67 0.310109672 ST6GALNAC6 ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N- 113.89 58.270.379 acetylgalactosaminide alpha-2,6-sialyltransferase 6 109798 C6orf48Chromosome 6 open reading frame 48 221.40 98.21 0.207 110695 SF3B5Splicing factor 3b, subunit 5, 10 kDa 161.11 93.81 0.310 110849 ESRRAEstrogen-related receptor alpha 243.72 107.89 0.310 111286 MRPS11Mitochondrial ribosomal protein S11 118.62 52.84 0.207 111577 ITM2CIntegral membrane protein 2C 293.83 115.98 0.138 111801 ARS2 ARS2protein 213.16 99.08 0.276 112058 SIVA1 SIVA1, apoptosis-inducing factor161.23 58.99 0.345 112318 TOMM7 Translocase of outer mitochondrialmembrane 7 homolog (yeast) 406.79 253.67 0.276 112955 NUDT5 Nudix(nucleoside diphosphate linked moiety X)-type motif 5 197.68 94.29 0.276114033 SSR1 Signal sequence receptor, alpha (translocon-associatedprotein 161.00 68.79 0.207 alpha) 114286 CD9 CD9 antigen (p24) 239.20130.06 0.172 114412 TXNL1 Thioredoxin-like 1 117.31 93.59 0.207 115474RFC3 Replication factor C (activator 1) 3, 38 kDa 175.70 158.89 0.345115792 EXOSC7 Exosome component 7 134.25 74.20 0.207 116448 GLSGlutaminase 192.13 67.06 0.379 117176 PABPN1 Poly(A) binding protein,nuclear 1 124.05 80.27 0.276 117715 ST5 Suppression of tumorigenicity 5101.33 55.39 0.379 118110 BST2 Bone marrow stromal cell antigen 2 216.6884.28 0.241 118400 FSCN1 Fascin homolog 1, actin-bundling protein(Strongylocentrotus 684.83 91.57 0.241 purpuratus) 118463 PNPLA2Patatin-like phospholipase domain containing 2 162.21 88.10 0.345 118638NME1 Non-metastatic cells 1, protein (NM23A) expressed in 290.12 103.600.172 118722 FUT8 Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)118.38 149.55 0.379 118964 GATAD2A GATA zinc finger domain containing 2A124.22 85.19 0.310 118983 GSDMDC1 Gasdermin domain containing 1 184.8795.75 0.379 119177 ARF3 ADP-ribosylation factor 3 239.68 76.49 0.138119192 H2AFZ H2A histone family, member Z 453.31 159.40 0.103 119251UQCRC1 Ubiquinol-cytochrome c reductase core protein 1 442.99 74.480.103 119591 AP2S1 Adaptor-related protein complex 2, sigma 1 subunit177.74 82.21 0.241 119598 RPL3 Ribosomal protein L3 3807.92 79.61 0.000120323 LOC26010 Viral DNA polymerase-transactivated protein 6 128.3569.74 0.310 121088 NUP153 Nucleoporin 153 kDa 123.13 79.84 0.310 121549CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 177.9881.88 0.241 (phosphatidylinositol synthase) 122363 WIPI2 WD repeatdomain, phosphoinositide interacting 2 186.76 89.61 0.138 122523 SND1Staphylococcal nuclease domain containing 1 355.50 74.36 0.034 124126ARPC1A Actin related protein 2/3 complex, subunit 1A, 41 kDa 206.4681.13 0.103 124147 FBXL11 PRO1880 protein 144.07 78.43 0.207 124246C10orf119 Chromosome 10 open reading frame 119 144.50 66.52 0.172 124366BBX Bobby sox homolog (Drosophila) 147.83 66.94 0.345 125113 CCT8Chaperonin containing TCP1, subunit 8 (theta) 187.53 84.03 0.034 125867EVL Enah/Vasp-like 170.08 84.54 0.276 125898 GNAS GNAS complex locus669.01 93.40 0.069 126497 AEBP2 AE binding protein 2 102.85 77.77 0.379126774 DTL Denticleless homolog (Drosophila) 160.79 71.32 0.379 126938NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 196.9284.26 0.069 127092 DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38168.85 103.87 0.379 127249 SNF8 SNF8, ESCRT-II complex subunit, homolog(S. cerevisiae) 134.67 80.08 0.310 127386 MAMDC2 MAM domain containing 2147.47 78.47 0.241 127764 RAB5C RAB5C, member RAS oncogene family 242.33112.45 0.276 128065 CTSC Cathepsin C 238.81 102.05 0.207 128199 SEPT11Septin 11 159.83 63.97 0.241 128548 WDR1 WD repeat domain 1 267.90 69.810.069 129634 CINP Cyclin-dependent kinase 2-interacting protein 104.5370.89 0.345 129673 EIF4A1 Eukaryotic translation initiation factor 4A,isoform 1 1492.15 82.19 0.000 130031 TRIO Triple functional domain(PTPRF interacting) 142.59 75.94 0.310 130098 DDX23 DEAD(Asp-Glu-Ala-Asp) box polypeptide 23 188.55 94.45 0.172 130293 CROPCisplatin resistance-associated overexpressed protein 152.55 84.06 0.207130413 TM9SF2 Transmembrane 9 superfamily member 2 210.83 99.09 0.103131226 BNIP3L BCL2/adenovirus E1B 19 kDa interacting protein 3-like192.67 70.38 0.241 132497 PRNPIP Prion protein interacting protein168.32 67.74 0.310 132513 HSD17B12 Hydroxysteroid (17-beta)dehydrogenase 12 137.10 95.65 0.207 133892 TPM1 Tropomyosin 1 (alpha)606.98 169.48 0.207 134074 SLC35E1 Solute carrier family 35, member E1110.83 70.67 0.345 134688 PSMD13 Proteasome (prosome, macropain) 26Ssubunit, non-ATPase, 13 304.05 104.85 0.207 135406 CEBPZ CCAAT/enhancerbinding protein zeta 126.72 64.41 0.207 136905 HUWE1 HECT, UBA and WWEdomain containing 1 196.13 66.09 0.138 136947 RALY RNA binding protein,autoantigenic (hnRNP-associated with lethal 339.69 92.28 0.069 yellowhomolog (mouse)) 137510 NCOR2 Nuclear receptor co-repressor 2 243.82126.40 0.207 138860 ARHGAP1 Rho GTPase activating protein 1 106.56 50.870.310 139896 MAEA Macrophage erythroblast attacher 203.45 84.45 0.276140452 M6PRBP1 Mannose-6-phosphate receptor binding protein 1 381.09119.04 0.138 142442 HP1BP3 Heterochromatin protein 1, binding protein 3161.28 66.57 0.207 143187 DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide49 144.35 67.10 0.241 143766 ATN1 Atrophin 1 184.56 86.85 0.207 143873S100A10 S100 calcium binding protein A10 (annexin II ligand, calpactinI, 255.56 111.88 0.172 light polypeptide (p11)) 144058 NAT9N-acetyltransferase 9 99.56 67.02 0.345 144468 CHID1 Chitinase domaincontaining 1 179.03 105.35 0.241 144835 EEF1G Eukaryotic translationelongation factor 1 gamma 4056.39 76.55 0.000 144868 VTI1B Vesicletransport through interaction with t-SNAREs homolog 1B 103.57 54.850.310 (yeast) 144941 LRRC41 Leucine rich repeat containing 41 152.4071.74 0.172 144949 ZNF313 Zinc finger protein 313 145.79 62.78 0.138144980 SCAMP4 Secretory carrier membrane protein 4 127.39 96.37 0.345145049 PLEKHM2 Pleckstrin homology domain containing, family M (with RUN205.68 86.88 0.138 domain) member 2 145442 MAP2K1 Mitogen-activatedprotein kinase kinase 1 101.59 55.16 0.241 145575 UBL3 Ubiquitin-like 3157.68 79.65 0.345 146070 TPM3 Tropomyosin 3 695.80 102.33 0.000 146393HERPUD1 Homocysteine-inducible, endoplasmic reticulum stress-inducible,226.44 86.29 0.172 ubiquitin-like domain member 1 146602 UQCRQUbiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa193.38 169.43 0.276 146804 SPIN1 Spindlin 1 127.00 68.69 0.345 146806CUL1 Cullin 1 120.27 57.50 0.207 147433 PCNA Proliferating cell nuclearantigen 258.31 133.96 0.172 148078 UBR4 Ubiquitin protein ligase E3component n-recognin 4 144.18 73.44 0.138 148272 CCM2 Cerebral cavernousmalformation 2 199.79 94.01 0.207 148330 ARF4 ADP-ribosylation factor 4385.93 105.50 0.138 148340 PTPRG Protein tyrosine phosphatase, receptortype, G 1592.61 150.52 0.069 148670 RHOBTB1 Rho-related BTB domaincontaining 1 116.95 99.14 0.345 149004 FBXO31 F-box protein 31 141.6381.88 0.379 149957 RPS6KA1 Ribosomal protein S6 kinase, 90 kDa,polypeptide 1 146.89 140.85 0.310 149983 PEX14 Peroxisomal biogenesisfactor 14 132.69 140.50 0.241 150107 BIRC6 Baculoviral IAPrepeat-containing 6 (apollon) 149.90 66.77 0.345 150540 TMEM112BTransmembrane protein 112B 180.63 177.93 0.379 150580 EIF1 Eukaryotictranslation initiation factor 1 458.80 84.42 0.034 150837 TXNDC5Thioredoxin domain containing 5 483.23 126.33 0.034 151134 OXA1L Oxidase(cytochrome c) assembly 1-like 238.54 70.29 0.103 151220 PALLD Palladin,cytoskeletal associated protein 198.94 75.04 0.345 151413 GMFB Gliamaturation factor beta 190.53 95.31 0.379 151787 EFTUD2 Elongationfactor Tu GTP binding domain containing 2 326.78 81.27 0.069 152536PSMD6 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 134.1463.78 0.241 153177 RPS28 Ribosomal protein S28 437.53 297.35 0.241154023 TXNDC4 Thioredoxin domain containing 4 (endoplasmic reticulum)133.74 72.55 0.345 154073 SLC35B1 Solute carrier family 35, member B199.61 61.75 0.379 155165 ZFPL1 Zinc finger protein-like 1 156.23 92.720.310 155218 HNRPUL1 Heterogeneous nuclear ribonucleoprotein U-like 1474.38 82.52 0.000 155396 NFE2L2 Nuclear factor (erythroid-derived2)-like 2 182.54 63.38 0.172 155829 TBC1D9B TBC1 domain family, member9B (with GRAM domain) 189.13 67.14 0.241 156171 PSMC6 Proteasome(prosome, macropain) 26S subunit, ATPase, 6 202.42 86.99 0.172 156367RPS29 Ribosomal protein S29 735.43 357.07 0.241 156667 CALCOCO Calciumbinding and coiled-coil domain 1 150.95 83.49 0.276 157160 MRPS34Mitochondrial ribosomal protein S34 163.79 79.67 0.276 157351 GTPBP9GTP-binding protein 9 (putative) 256.77 85.59 0.207 157379 H2AFV H2Ahistone family, member V 212.94 72.40 0.138 157394 HAGHHydroxyacylglutathione hydrolase 110.09 79.63 0.345 159014 PRPF4B PRP4pre-mRNA processing factor 4 homolog B (yeast) 101.54 63.09 0.379 159118AMD1 Adenosylmethionine decarboxylase 1 179.16 87.63 0.241 159130 RAF1V-raf-1 murine leukemia viral oncogene homolog 1 148.50 123.34 0.138159161 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 781.87 98.280.138 159699 FBXO21 F-box protein 21 112.15 59.46 0.345 159799 THRAP2Thyroid hormone receptor associated protein 2 135.37 68.96 0.345 160958CDC37 CDC37 cell division cycle 37 homolog (S. cerevisiae) 297.55 114.770.069 161357 PDHB Pyruvate dehydrogenase (lipoamide) beta 188.51 80.700.172 162032 HBP1 HMG-box transcription factor 1 119.42 40.70 0.345162233 CHD4 Chromodomain helicase DNA binding protein 4 294.77 95.150.207 162877 PACSIN2 Protein kinase C and casein kinase substrate inneurons 2 181.10 101.47 0.207 163645 MOCS2 Molybdenum cofactor synthesis2 123.58 91.10 0.276 163776 UBE2J1 Ubiquitin-conjugating enzyme E2, J1(UBC6 homolog, yeast) 229.95 250.60 0.310 163893 PICALMPhosphatidylinositol binding clathrin assembly protein 153.29 84.250.310 165195 VAPA VAMP (vesicle-associated membrane protein)-associatedprotein 170.73 76.58 0.069 A, 33 kDa 166011 CTNND1 Catenin(cadherin-associated protein), delta 1 181.39 76.07 0.138 166204 PHF1PHD finger protein 1 128.96 77.28 0.345 166463 HNRPU Heterogeneousnuclear ribonucleoprotein U (scaffold attachment 279.34 89.13 0.034factor A) 166924 SEC13 SEC13 homolog (S. cerevisiae) 164.56 70.57 0.207166975 SFRS5 Splicing factor, arginine/serine-rich 5 241.85 95.20 0.138167535 SRP54 Signal recognition particle 54 kDa 132.08 105.35 0.241168073 TRPC4AP Transient receptor potential cation channel, subfamily C,member 174.32 67.74 0.241 4 associated protein 168799 METTL3Methyltransferase like 3 133.88 65.22 0.172 169611 DIABLO Diablo homolog(Drosophila) 167.55 69.66 0.276 169718 CNN2 Calponin 2 263.90 111.610.138 170107 UQCRFS1 Ubiquinol-cytochrome c reductase, Rieskeiron-sulfur polypeptide 112.20 75.09 0.241 170131 NFIC Nuclear factorI/C (CCAAT-binding transcription factor) 128.62 75.64 0.379 170553 CNOT7CCR4-NOT transcription complex, subunit 7 119.98 77.62 0.276 170622 CFL1Cofilin 1 (non-muscle) 1372.26 96.41 0.034 171626 SKP1A S-phasekinase-associated protein 1A (p19A) 457.12 128.78 0.138 172550 PTBP1Polypyrimidine tract binding protein 1 554.08 85.76 0.103 172755 BRP44LBrain protein 44-like 150.10 97.09 0.379 172928 COL1A1 Collagen, type I,alpha 1 657.85 170.49 0.276 173024 NUB1 Negative regulator ofubiquitin-like proteins 1 102.38 55.09 0.276 173162 COX4NB COX4 neighbor259.86 100.34 0.310 173381 DPYSL2 Dihydropyrimidinase-like 2 213.6276.62 0.310 173464 FKBP8 FK506 binding protein 8, 38 kDa 446.43 105.380.103 173611 NDUFS2 NADH dehydrogenase (ubiquinone) Fe—S protein 2, 49kDa 308.98 100.60 0.069 (NADH-coenzyme Q reductase) 173705 LOC40115 HCVF-transactivated protein 1 155.92 91.92 0.207 173724 CKB Creatinekinase, brain 395.40 117.54 0.310 174050 EDF1 Endothelialdifferentiation-related factor 1 163.11 77.20 0.345 174195 IFITM2Interferon induced transmembrane protein 2 (1-8D) 439.92 224.90 0.276175473 AK1 Adenylate kinase 1 115.05 96.67 0.345 175955 YTHDC1 YTHdomain containing 1 114.99 56.92 0.310 177530 ATP5E ATP synthase, H+transporting, mitochondrial F1 complex, epsilon 343.57 172.81 0.207subunit 177766 PARP1 Poly (ADP-ribose) polymerase family, member 1260.77 114.80 0.103 178551 RPL8 Ribosomal protein L8 1600.62 93.63 0.034178728 MBD3 Methyl-CpG binding domain protein 3 226.33 93.86 0.241179986 FLOT1 Flotillin 1 239.64 133.66 0.241 180141 CFL2 Cofilin 2(muscle) 236.22 198.55 0.345 180312 MRPS16 Mitochondrial ribosomalprotein S16 148.32 71.61 0.276 180414 HSPA8 Heat shock 70 kDa protein 81204.20 99.10 0.000 180877 H3F3B H3 histone, family 3B (H3.3B) 701.3571.33 0.000 180903 NCAPH2 Non-SMC condensin II complex, subunit H2273.31 91.43 0.310 180909 PRDX1 Peroxiredoxin 1 973.56 146.34 0.138180933 CXXC1 CXXC finger 1 (PHD domain) 127.97 58.18 0.345 181046 DUSP3Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1- 168.09115.04 0.207 related) 181112 MED4 Mediator of RNA polymerase IItranscription, subunit 4 homolog 208.67 152.66 0.276 (yeast) 181163HMGN2 High-mobility group nucleosomal binding domain 2 798.73 84.120.000 181244 HLA-A Major histocompatibility complex, class I, A 874.9596.35 0.138 181368 PRPF8 PRP8 pre-mRNA processing factor 8 homolog(yeast) 308.98 76.46 0.138 181444 TMEM9 Transmembrane protein 9 210.7080.44 0.172 182255 NHP2L1 NHP2 non-histone chromosome protein 2-like 1(S. cerevisiae) 236.95 69.85 0.069 182626 C22orf5 Chromosome 22 openreading frame 5 189.45 87.32 0.310 182885 SLC35B2 Solute carrier family35, member B2 197.27 131.49 0.241 183684 EIF4G2 Eukaryotic translationinitiation factor 4 gamma, 2 571.05 99.96 0.069 183706 ADD1 Adducin 1(alpha) 210.75 70.37 0.138 183800 RANGAP1 Ran GTPase activating protein1 330.34 92.47 0.172 183850 DCTD DCMP deaminase 140.58 59.00 0.345183994 PPP1CA Protein phosphatase 1, catalytic subunit, alpha isoform374.52 71.55 0.103 184062 C20orf24 Chromosome 20 open reading frame 24161.95 77.22 0.310 184211 PMPCB Peptidase (mitochondrial processing)beta 177.15 64.50 0.138 184233 HSPA9 Heat shock 70 kDa protein 9(mortalin) 311.24 80.92 0.034 184492 ELAVL1 ELAV (embryonic lethal,abnormal vision, Drosophila)-like 1 (Hu 130.66 66.07 0.207 antigen R)185172 GNB2 Guanine nucleotide binding protein (G protein), betapolypeptide 2 420.89 178.43 0.172 185597 SPG7 Spastic paraplegia 7,paraplegin (pure and complicated autosomal 167.10 102.17 0.207recessive) 187199 MALAT1 Metastasis associated lung adenocarcinomatranscript 1 (non- 3984.95 243.42 0.241 coding RNA) 187635 RPS15AChromosome 20 open reading frame 19 705.06 435.58 0.138 187763 BRD4Bromodomain containing 4 226.90 138.89 0.241 187866 NPTN Neuroplastin120.12 53.64 0.379 187946 SLC20A1 Solute carrier family 20 (phosphatetransporter), member 1 141.36 96.84 0.207 188501 PAFAH1B2Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit149.54 78.69 0.138 30 kDa 188614 PLEKHA5 Pleckstrin homology domaincontaining, family A member 5 115.79 66.94 0.379 188879 RBM6 RNA bindingmotif protein 6 100.43 54.89 0.379 188882 NUDT3 Nudix (nucleosidediphosphate linked moiety X)-type motif 3 129.54 63.13 0.276 189075 TWF1Twinfilin, actin-binding protein, homolog 1 (Drosophila) 164.98 70.220.310 189119 CXXC5 CXXC finger 5 97.63 45.99 0.345 189329 SMURF1 SMADspecific E3 ubiquitin protein ligase 1 126.19 77.52 0.379 189716 NDUFAB1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 224.8587.06 0.276 8 kDa 189772 CCT2 Chaperonin containing TCP1, subunit 2(beta) 269.61 95.66 0.069 190028 GSTO1 Glutathione S-transferase omega 1178.51 92.79 0.241 190086 MRCL3 Myosin regulatory light chain MRCL3469.83 322.83 0.172 190334 RAP1A RAP1A, member of RAS oncogene family130.79 76.47 0.310 190384 COPS4 COP9 constitutive photomorphogenichomolog subunit 4 163.76 100.38 0.138 (Arabidopsis) 190722 C19orf62Chromosome 19 open reading frame 62 218.33 85.79 0.207 190904 STRN4Striatin, calmodulin binding protein 4 183.13 100.67 0.241 191186 TTC17Tetratricopeptide repeat domain 17 125.42 63.68 0.310 191346 SEPT7Septin 7 318.59 80.82 0.103 191518 DHX9 DEAH (Asp-Glu-Ala-His) boxpolypeptide 9 239.90 67.53 0.241 191987 UBE2J2 Ubiquitin-conjugatingenzyme E2, J2 (UBC6 homolog, yeast) 125.95 71.90 0.207 192316 CDC2L1Cell division cycle 2-like 1 (PITSLRE proteins) 102.48 85.83 0.379192374 HSP90B1 Heat shock protein 90 kDa beta (Grp94), member 1 388.1288.21 0.034 192425 EIF3S8 Eukaryotic translation initiation factor 3,subunit 8, 110 kDa 1001.22 91.36 0.103 193118 ZMIZ1 Zinc finger,MIZ-type containing 1 125.42 71.59 0.345 193163 BIN1 Bridging integrator1 216.65 88.45 0.241 193491 TUBB6 Tubulin, beta 6 255.15 94.70 0.241194329 TCEAL4 Transcription elongation factor A (SII)-like 4 110.7660.41 0.207 194718 ZRANB2 Zinc finger, RAN-binding domain containing 2170.63 70.34 0.207 195464 FLNA Filamin A, alpha (actin binding protein280) 554.90 92.75 0.172 195642 RNF213 Ring finger protein 213 146.0274.10 0.379 196983 SSFA2 Sperm specific antigen 2 238.74 197.56 0.241198281 PKM2 Pyruvate kinase, muscle 3044.33 101.80 0.000 199561 RANBP2RAN binding protein 2 134.09 59.13 0.379 199625 HAX1 HCLS1 associatedprotein X-1 243.58 94.74 0.138 200063 HDAC7A Histone deacetylase 7A252.27 159.81 0.241 200600 SCAMP3 Secretory carrier membrane protein 3165.58 75.71 0.207 200804 SDCBP Syndecan binding protein (syntenin)355.16 73.99 0.172 201253 CKAP5 Cytoskeleton associated protein 5 157.7177.53 0.069 201390 WDR45L WDR45-like 115.15 53.09 0.138 201712 GLG1Golgi apparatus protein 1 128.23 88.99 0.310 202011 CCDC47 Coiled-coildomain containing 47 108.62 67.48 0.172 202085 VDAC1 Voltage-dependentanion channel 1 179.22 70.07 0.276 202166 HNRPH1 Heterogeneous nuclearribonucleoprotein H1 (H) 199.33 74.31 0.069 202179 SMN2 Survival ofmotor neuron 1, telomeric 103.17 55.27 0.379 203099 WAPAL Wingsapart-like homolog (Drosophila) 162.13 143.02 0.345 203910 SGTA Smallglutamine-rich tetratricopeptide repeat (TPR)-containing, 213.58 79.650.138 alpha 204041 AHSA1 AHA1, activator of heat shock 90 kDa proteinATPase homolog 1 263.29 112.20 0.207 (yeast) 204773 WDR77 WD repeatdomain 77 185.81 74.28 0.172 205163 MRPL3 Mitochondrial ribosomalprotein L3 176.93 58.08 0.069 206500 CTTN Cortactin 148.63 96.70 0.310206824 MGC71993 Similar to DNA segment, Chr 11, Brigham &amp; Womens143.54 88.77 0.345 Genetics 0434 expressed 208597 CTBP1 Hypotheticalprotein LOC285463 136.74 48.53 0.138 209983 STMN1 Stathmin 1/oncoprotein18 619.09 139.81 0.034 210469 ELMO2 Engulfment and cell motility 2(ced-12 homolog, C. elegans) 96.39 71.43 0.379 210532 KIAA0141 KIAA0141138.36 72.99 0.241 211463 DNM2 Dynamin 2 195.67 87.32 0.241 211594 PSMC4Proteasome (prosome, macropain) 26S subunit, ATPase, 4 469.59 192.260.138 211914 NDUFS7 NADH dehydrogenase (ubiquinone) Fe—S protein 7, 20kDa 159.44 73.80 0.379 (NADH-coenzyme Q reductase) 212102 PDIA6 Proteindisulfide isomerase family A, member 6 274.17 97.91 0.103 212395 CIZ1CDKN1A interacting zinc finger protein 1 272.61 88.59 0.138 213061NUCKS1 Nuclear casein kinase and cyclin-dependent kinase substrate 1304.71 64.96 0.138 213470 PSMB7 Proteasome (prosome, macropain) subunit,beta type, 7 247.81 65.94 0.034 213541 LOC55288 Hypothetical LOC552889136.06 60.14 0.345 213666 KIAA0460 KIAA0460 96.71 78.04 0.241 213724SUPT16H Suppressor of Ty 16 homolog (S. cerevisiae) 149.27 79.71 0.207216653 FBXO9 F-box protein 9 92.27 49.72 0.310 220950 FOXO3 Forkhead boxO3 196.88 112.74 0.276 221847 SLC38A2 Solute carrier family 38, member 2204.23 78.33 0.207 222510 DAZAP1 DAZ associated protein 1 126.05 97.180.276 223141 DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 255.5470.08 0.069 224607 SDC1 Syndecan 1 241.65 87.87 0.276 226007 RDH11Retinol dehydrogenase 11 (all-trans and 9-cis) 340.36 135.94 0.172226117 H1F0 H1 histone family, member 0 326.85 160.18 0.310 226755 YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase 199.21 161.02 0.207activation protein, eta polypeptide 227067 ATAD3A ATPase family, AAAdomain containing 3A 254.68 105.30 0.172 227253 TOMM70A Translocase ofouter mitochondrial membrane 70 homolog A 130.67 67.31 0.172 (yeast)227777 PTP4A1 Protein tyrosine phosphatase type IVA, member 1 219.08115.20 0.138 229641 SUB1 SUB1 homolog (S. cerevisiae) 300.51 103.710.138 231295 PITPNC1 Phosphatidylinositol transfer protein, cytoplasmic1 171.09 127.31 0.345 231616 C19orf53 Chromosome 19 open reading frame53 162.05 104.55 0.345 232194 KIAA0174 KIAA0174 204.24 73.78 0.138232543 PDCD4 Programmed cell death 4 (neoplastic transformationinhibitor) 126.25 61.41 0.310 233458 NFYC Nuclear transcription factorY, gamma 92.20 51.11 0.345 233552 CDC2L5 Cell division cycle 2-like 5(cholinesterase-related cell division 139.27 109.94 0.379 controller)233952 PSMA7 Proteasome (prosome, macropain) subunit, alpha type, 7358.81 133.21 0.069 234521 MAPKAPK3 Mitogen-activated proteinkinase-activated protein kinase 3 185.75 77.03 0.379 236030 SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of 198.0783.50 0.207 chromatin, subfamily c, member 2 237536 NT5C3L5′-nucleotidase, cytosolic III-like 160.67 84.27 0.276 237971 XTP3TPAXTP3-transactivated protein A 122.34 67.16 0.276 238839 SCYL1 SCY1-like1 (S. cerevisiae) 173.16 113.72 0.310 240170 OBFC2BOligonucleotide/oligosaccharide-binding fold containing 2B 136.42 69.860.345 241336 ATPIF1 ATPase inhibitory factor 1 227.40 125.29 0.172241543 POLDIP2 Polymerase (DNA-directed), delta interacting protein 2217.98 81.62 0.138 241558 ARIH2 Ariadne homolog 2 (Drosophila) 178.4577.54 0.172 241575 GNPTG N-acetylglucosamine-1-phosphate transferase,gamma subunit 117.17 100.69 0.345 241576 DERL1 Der1-like domain family,member 1 111.58 87.37 0.310 241579 SERPINH1 Serpin peptidase inhibitor,clade H (heat shock protein 47), 380.44 115.76 0.172 member 1, (collagenbinding protein 1) 242458 SPG21 Spastic paraplegia 21 (autosomalrecessive, Mast syndrome) 120.35 59.44 0.310 242947 DGKI Diacylglycerolkinase, iota 131.75 120.70 0.379 246112 ASCC3L1 Activating signalcointegrator 1 complex subunit 3-like 1 278.46 81.24 0.172 246310 ATP5JATP synthase, H+ transporting, mitochondrial F0 complex, subuni 220.45113.90 0.276 F6 246413 CPNE1 RNA binding motif protein 12 392.42 88.160.069 246781 FBXO11 F-box protein 11 141.20 92.55 0.379 247077 RHOA Rashomolog gene family, member A 553.79 77.72 0.034 247186 FBRS Fibrosin145.20 107.50 0.379 247975 HSPD1 Pro-melanin-concentrating hormone-like1 241.69 85.58 0.207 248267 MPST Mercaptopyruvate sulfurtransferase167.67 112.86 0.276 248941 TAF9 TAF9 RNA polymerase II, TATA box bindingprotein (TBP)- 148.14 65.92 0.276 associated factor, 32 kDa 249600DLGAP4 Discs, large (Drosophila) homolog-associated protein 4 233.49169.10 0.276 250009 ARL8B ADP-ribosylation factor-like 8B 132.27 55.790.379 250429 SUPT6H Suppressor of Ty 6 homolog (S. cerevisiae) 162.2582.76 0.379 250758 PSMC3 Proteasome (prosome, macropain) 26S subunit,ATPase, 3 391.11 115.64 0.138 250899 HSBP1 Heat shock factor bindingprotein 1 214.94 105.83 0.069 250905 TMEM85 Transmembrane protein 85156.08 143.74 0.241 251531 PSMA4 Proteasome (prosome, macropain)subunit, alpha type, 4 739.81 217.34 0.138 252457 MVD Mevalonate(diphospho) decarboxylase 170.93 117.34 0.379 252713 TTC15Tetratricopeptide repeat domain 15 105.62 56.20 0.345 252967 C1orf144Chromosome 1 open reading frame 144 240.90 109.65 0.207 253726 PAPOLAPoly(A) polymerase alpha 216.15 65.36 0.172 253903 STOM Stomatin 199.17100.65 0.276 254042 BAT1 HLA-B associated transcript 1 351.44 89.430.069 255015 VPS24 Vacuolar protein sorting 24 (yeast) 126.82 67.800.069 255093 PFKL Phosphofructokinase, liver 342.69 81.83 0.207 255932XRN2 5′-3′ exoribonuclease 2 166.16 57.70 0.069 255935 BTG1 B-celltranslocation gene 1, anti-proliferative 272.14 115.44 0.138 255973 EID1EP300 interacting inhibitor of differentiation 1 227.90 86.79 0.138256301 C19orf48 Chromosome 19 open reading frame 48 337.67 84.54 0.207256549 NUBP2 Nucleotide binding protein 2 (MinD homolog, E. coli) 200.7598.94 0.241 257008 PLD3 Phospholipase D family, member 3 349.21 100.000.276 257341 SAV1 Salvador homolog 1 (Drosophila) 91.57 65.55 0.276257761 SH3BP5 SH3-domain binding protein 5 (BTK-associated) 170.93 92.540.345 258551 DNPEP Aspartyl aminopeptidase 168.16 84.05 0.138 258563FEZ2 Fasciculation and elongation protein zeta 2 (zygin II) 190.19204.72 0.345 258798 NSMCE4A Non-SMC element 4 homolog A (S. cerevisiae)79.52 52.34 0.345 259461 PALM2- PALM2-AKAP2 protein 171.91 79.41 0.310AKAP2 260603 PIP5K2B Phosphatidylinositol-4-phosphate 5-kinase, type II,beta 132.75 67.00 0.276 262823 IARS2 Isoleucyl-tRNA synthetase 2,mitochondrial 139.24 59.53 0.345 265829 ITGA3 Integrin, alpha 3 (antigenCD49C, alpha 3 subunit of VLA-3 404.31 148.83 0.379 receptor) 268488LRRC47 Leucine rich repeat containing 47 115.89 116.32 0.379 268530 GPS1Radical fringe homolog (Drosophila) 263.51 64.58 0.138 268742 POMPProteasome maturation protein 213.22 98.49 0.276 268849 GLO1 GlyoxalaseI 293.88 85.24 0.138 268939 MATR3 Matrin 3 292.73 68.23 0.034 269528NAT13 N-acetyltransferase 13 237.37 198.20 0.172 269577 PTPRA Proteintyrosine phosphatase, receptor type, A 183.68 82.75 0.207 269782 GNAQGuanine nucleotide binding protein (G protein), q polypeptide 174.12105.06 0.241 269944 MTCH2 Mitochondrial carrier homolog 2 (C. elegans)158.42 74.35 0.103 270291 ACTN4 Actinin, alpha 4 341.13 108.40 0.172270428 SUCLG1 Succinate-CoA ligase, GDP-forming, alpha subunit 242.34241.99 0.241 270525 LASS5 LAG1 longevity assurance homolog 5 (S.cerevisiae) 111.31 73.14 0.379 270869 ZNF410 Zinc finger protein 410135.77 84.28 0.172 271135 ATP5C1 ATP synthase, H+ transporting,mitochondrial F1 complex, gamma 448.47 176.19 0.172 polypeptide 1 271695NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 111.46 73.070.310 272062 PTPRF Protein tyrosine phosphatase, receptor type, F 269.1088.46 0.310 272168 SERINC3 Serine incorporator 3 121.11 72.44 0.138272630 ATP6V1D ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D149.33 85.72 0.207 272927 SEC23A Sec23 homolog A (S. cerevisiae) 128.2474.07 0.379 273077 TMEM14B Transmembrane protein 14B 128.20 70.29 0.345274184 TFE3 Transcription factor binding to IGHM enhancer 3 111.31 57.200.276 274772 C15orf15 Chromosome 15 open reading frame 15 1163.64 205.160.172 274873 CARS Cysteinyl-tRNA synthetase 176.72 76.48 0.207 275243S100A6 S100 calcium binding protein A6 (calcyclin) 361.59 101.08 0.103275775 SEPP1 Selenoprotein P, plasma, 1 543.33 189.21 0.379 275865 PCNPPEST-containing nuclear protein 315.34 88.79 0.069 276878 NUP93Nucleoporin 93 kDa 101.32 60.26 0.241 277035 MGLL Monoglyceride lipase399.51 211.97 0.379 277517 C11orf2 Chromosome 11 open reading frame 2193.83 84.84 0.241 278186 ARHGEF1 Rho guanine nucleotide exchange factor(GEF) 1 194.28 91.63 0.345 278362 MEA1 Male-enhanced antigen 1 152.6083.00 0.276 278426 PDAP1 PDGFA associated protein 1 184.93 86.49 0.172278429 C9orf78 Chromosome 9 open reading frame 78 109.74 79.17 0.276278500 GNPDA1 Glucosamine-6-phosphate deaminase 1 174.64 74.75 0.241278569 SNX17 Sorting nexin 17 297.66 66.25 0.069 278573 CD59 CD59antigen p18-20 (antigen identified by monoclonal antibodies 336.75 91.210.138 16.3A5, EJ16, EJ30, EL32 and G344) 278721 SLC39A7 Solute carrierfamily 39 (zinc transporter), member 7 147.65 72.58 0.379 279061 GLOD4Glyoxalase domain containing 4 148.90 76.66 0.172 279245 TACC1Transforming, acidic coiled-coil containing protein 1 186.16 79.86 0.241279257 PCMT1 Protein-L-isoaspartate (D-aspartate) O-methyltransferase172.73 62.20 0.103 279413 POLD1 Polymerase (DNA directed), delta 1,catalytic subunit 125 kDa 164.91 99.93 0.276 279529 PRELID1 PRELI domaincontaining 1 224.95 77.28 0.172 279583 METTL9 Methyltransferase like 9183.44 155.70 0.241 279623 SEPX1 Selenoprotein X, 1 117.70 54.66 0.345279640 TPR Translocated promoter region (to activated MET oncogene)94.90 66.61 0.310 279652 MRPL4 Mitochondrial ribosomal protein L4 173.4073.00 0.276 279669 TUBG1 Tubulin, gamma 1 169.58 65.01 0.310 279696SUMF2 Sulfatase modifying factor 2 149.85 83.02 0.345 279806 DDX5RNA-binding protein 45 (RBP45), putative 457.60 87.95 0.103 279836COMMD9 COMM domain containing 9 104.98 49.94 0.379 279920 YWHAB Tyrosine3-monooxygenase/tryptophan 5-monooxygenase 288.39 87.94 0.034 activationprotein, beta polypeptide 279929 TMED9 Transmembrane emp24 proteintransport domain containing 9 291.55 91.04 0.069 280202 SBF1 SET bindingfactor 1 382.01 317.21 0.310 280342 PRKAR1A Protein kinase,cAMP-dependent, regulatory, type I, alpha (tissue 266.02 111.27 0.103specific extinguisher 1) 280378 SNRPB2 Small nuclear ribonucleoproteinpolypeptide B″ 243.47 100.43 0.310 282410 CALM1 Calmodulin 1(phosphorylase kinase, delta) 246.78 67.76 0.103 282700 SPCS2 Signalpeptidase complex subunit 2 homolog (S. cerevisiae) 232.99 84.36 0.207282901 RBM39 RNA binding motif protein 39 166.92 85.70 0.138 282998 RBM9RNA binding motif protein 9 477.00 221.29 0.103 283111 C14orf124Chromosome 14 open reading frame 124 168.06 139.52 0.207 283454 BNIP2BCL2/adenovirus E1B 19 kDa interacting protein 2 130.03 68.79 0.310283521 RHEB Ras homolog enriched in brain 193.25 113.28 0.310 283610ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 180.36 88.440.172 283652 IDI1 Isopentenyl-diphosphate delta isomerase 1 233.34102.32 0.241 283739 UBQLN4 Ubiquilin 4 165.35 84.58 0.207 284208 ANKRD25Ankyrin repeat domain 25 124.68 85.84 0.379 284279 HMOX2 Heme oxygenase(decycling) 2 151.53 85.91 0.310 284286 MRPS24 Mitochondrial ribosomalprotein S24 136.83 77.51 0.345 284491 PDXK Pyridoxal (pyridoxine,vitamin B6) kinase 235.50 93.74 0.138 285354 MAX MYC associated factor X109.16 60.60 0.345 285976 LASS2 LAG1 longevity assurance homolog 2 (S.cerevisiae) 203.17 82.28 0.172 286221 ARF1 ADP-ribosylation factor 1704.87 66.67 0.069 286226 MYO1C Myosin IC 253.69 114.87 0.310 288193KPNA4 Karyopherin alpha 4 (importin alpha 3) 144.60 134.58 0.379 288856PFDN5 Prefoldin 5 226.65 96.63 0.103 288969 NMRAL1 NmrA-like familydomain containing 1 126.04 77.91 0.379 289008 NUS1 Nuclear undecaprenylpyrophosphate synthase 1 homolog (S. cerevisiae) 157.63 95.67 0.310289092 COTL1 Coactosin-like 1 (Dictyostelium) 315.93 109.13 0.172 289123DCTN2 Dynactin 2 (p50) 261.39 105.34 0.069 289271 CYC1 Cytochrome c-1345.69 78.79 0.172 290243 GBF1 Golgi-specific brefeldin A resistancefactor 1 241.54 85.11 0.310 290404 SLC25A3 Solute carrier family 25(mitochondrial carrier; phosphate carrier), 1579.85 87.93 0.034 member 3290758 DDB1 Damage-specific DNA binding protein 1, 127 kDa 452.78 82.290.138 291587 ARID1B AT rich interactive domain 1B (SWI1-like) 135.9782.06 0.310 292026 EIF4E2 Eukaryotic translation initiation factor 4Emember 2 186.78 88.38 0.138 292063 EIF4B Hypothetical protein PRO1843439.43 110.97 0.103 292078 LARP1 La ribonucleoprotein domain family,member 1 246.82 65.22 0.069 292265 ZMYND11 Zinc finger, MYND domaincontaining 11 133.13 109.13 0.207 292457 SNHG5 Small nucleolar RNA hostgene (non-protein coding) 5 400.14 267.50 0.276 292493 XRCC6 X-rayrepair complementing defective repair in Chinese hamster 691.10 100.070.034 cells 6 (Ku autoantigen, 70 kDa) 292524 CCNH Cyclin H 158.48 96.800.276 292579 PTDSS1 Phosphatidylserine synthase 1 195.76 80.55 0.276293563 C1orf108 Chromosome 1 open reading frame 108 144.99 87.81 0.172295917 ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunitB, 151.09 76.58 0.207 isoform 2 297324 TIMP3 TIMP metallopeptidaseinhibitor 3 (Sorsby fundus dystrophy, 505.19 227.34 0.310pseudoinflammatory) 298198 CMTM3 CKLF-like MARVEL transmembrane domaincontaining 3 127.34 71.77 0.310 298280 ATP5A1 ATP synthase, H+transporting, mitochondrial F1 complex, alpha 1791.25 357.36 0.000subunit, isoform 1, cardiac muscle 298654 DUSP6 Dual specificityphosphatase 6 208.26 87.60 0.310 299002 FBL Fibrillarin 591.46 179.470.138 299055 GDI2 GDP dissociation inhibitor 2 323.73 77.59 0.069 300141RPL39 Ribosomal protein L39 775.36 419.08 0.172 300684 RCP9 Calcitoningene-related peptide-receptor component protein 79.62 45.89 0.241 300772TPM2 Tropomyosin 2 (beta) 881.72 370.12 0.345 300816 RAB1B RAB1B, memberRAS oncogene family 228.92 96.00 0.172 300834 GALNT2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- 155.76 89.15 0.241acetylgalactosaminyltransferase 2 (GalNAc-T2) 301404 RBM3 RNA bindingmotif (RNP1, RRM) protein 3 325.81 102.69 0.172 301412 UFC1Ubiquitin-fold modifier conjugating enzyme 1 142.19 76.03 0.276 302742MRPS6 Mitochondrial ribosomal protein S6 184.15 77.33 0.276 302903 UBE2IUbiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 178.40 82.890.172 303676 G3BP2 Ras-GTPase activating protein SH3 domain-bindingprotein 2 149.92 66.30 0.241 304192 DSTN Destrin (actin depolymerizingfactor) 223.11 77.62 0.207 304682 CST3 Cystatin C (amyloid angiopathyand cerebral hemorrhage) 266.47 126.42 0.172 306123 MAGEF1 Melanomaantigen family F, 1 183.67 83.29 0.379 306242 RANBP9 RAN binding protein9 116.92 67.43 0.310 306329 ZFAND6 Zinc finger, AN1-type domain 6 247.2899.07 0.276 306425 IBTK Inhibitor of Bruton agammaglobulinemia tyrosinekinase 104.18 51.87 0.379 308122 ITPK1 Inositol 1,3,4-triphosphate 5/6kinase 254.52 81.30 0.276 308340 NUP188 Nucleoporin 188 kDa 329.72144.04 0.241 308709 PDIA3 Protein disulfide isomerase family A, member 3204.27 87.48 0.069 309090 SFRS7 Splicing factor, arginine/serine-rich 7,35 kDa 189.69 89.49 0.172 309231 C6orf153 Chromosome 6 open readingframe 153 157.44 80.31 0.310 309641 RNF11 Ring finger protein 11 162.8268.82 0.172 309753 STARD3NL STARD3 N-terminal like 119.30 74.99 0.310309849 C14orf159 Chromosome 14 open reading frame 159 122.74 74.53 0.379310542 TOMM40 Translocase of outer mitochondrial membrane 40 homolog(yeast) 267.48 79.87 0.138 310645 RAB1A RAB1A, member RAS oncogenefamily 252.99 84.41 0.241 311072 MRPS35 Mitochondrial ribosomal proteinS35 138.81 64.82 0.345 311346 CMAS Cytidine monophosphateN-acetylneuraminic acid synthetase 109.31 97.45 0.345 311609 DDX39 DEAD(Asp-Glu-Ala-Asp) box polypeptide 39 260.02 110.28 0.138 311640 RPS27ARibosomal protein S27a 524.64 119.16 0.034 312098 ADAM15 ADAMmetallopeptidase domain 15 (metargidin) 200.26 132.76 0.345 313847TXNDC11 Thioredoxin domain containing 11 106.99 71.40 0.345 314263 BAZ2ABromodomain adjacent to zinc finger domain, 2A 164.92 91.68 0.241 314359EIF3S12 Eukaryotic translation initiation factor 3, subunit 12 248.91116.13 0.103 315177 IFRD2 Interferon-related developmental regulator 2180.25 60.11 0.276 315230 EIF1B Eukaryotic translation initiation factor1B 166.77 108.63 0.207 319334 NASP Nuclear autoantigenic sperm protein(histone-binding) 320.92 87.44 0.103 321391 ELOF1 Elongation factor 1homolog (S. cerevisiae) 119.51 68.26 0.345 321541 RAB11A RAB11A, memberRAS oncogene family 193.82 99.65 0.172 323363 ATG9A ATG9 autophagyrelated 9 homolog A (S. cerevisiae) 159.62 88.11 0.276 323489 PTCD3Pentatricopeptide repeat domain 3 153.29 80.62 0.172 324250 NDUFB2 NADHdehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8 kDa 245.74 182.660.379 324844 VKORC1 Vitamin K epoxide reductase complex, subunit 1151.74 66.24 0.276 325650 EHD2 EH-domain containing 2 160.03 99.53 0.379326387 MORF4L2 Mortality factor 4 like 2 313.02 109.69 0.103 330384CORO1C Coronin, actin binding protein, 1C 171.53 69.53 0.103 331431SCC-112 SCC-112 protein 242.38 75.28 0.069 333388 EEF1D Eukaryotictranslation elongation factor 1 delta (guanine nucleotide 899.57 105.630.000 exchange protein) 333579 HSPC152 Hypothetical protein HSPC152209.20 133.84 0.172 333786 PSMA2 Proteasome (prosome, macropain)subunit, alpha type, 2 207.24 97.57 0.138 333823 MRPL13 Mitochondrialribosomal protein L13 113.33 69.75 0.345 334017 TUBA1B Tubulin, alpha 1b1834.27 95.82 0.000 334479 TRAF7 TNF receptor-associated factor 7 242.13130.36 0.138 334534 GNS Glucosamine (N-acetyl)-6-sulfatase (Sanfilippodisease IIID) 129.18 72.76 0.276 334587 RBPMS RNA binding protein withmultiple splicing 136.68 59.93 0.345 334713 UBL7 Ubiquitin-like 7 (bonemarrow stromal cell-derived) 192.75 67.45 0.207 334851 LASP1 LIM and SH3protein 1 297.69 80.06 0.034 334868 PPP2R5E Protein phosphatase 2,regulatory subunit B (B56), epsilon isoform 111.74 78.51 0.345 335003ANKRD11 Ankyrin repeat domain 11 152.63 135.85 0.276 335057 SEPT2 Septin2 321.01 90.60 0.069 335163 LIMCH1 LIM and calponin homology domains 1217.46 84.47 0.379 335918 FDPS Farnesyl diphosphate synthase (farnesylpyrophosphate 635.55 104.20 0.034 synthetase,dimethylallyltranstransferase, geranyltranstransferase 337295 STIP1Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing 326.55 78.190.172 337766 TXNRD1 Thioredoxin reductase 1 641.30 103.44 0.034 339278COPB1 Coatomer protein complex, subunit beta 1 144.35 59.14 0.241 339639COX7A2L Cytochrome c oxidase subunit VIIa polypeptide 2 like 222.2184.81 0.241 339697 GRINA Glutamate receptor, ionotropic, N-methylD-asparate-associated 287.06 90.28 0.103 protein 1 (glutamate binding)343911 EI24 Etoposide induced 2.4 mRNA 172.38 72.77 0.103 345694 KCMF1Potassium channel modulatory factor 1 114.01 57.72 0.345 346868 EBNA1BP2EBNA1 binding protein 2 190.81 79.22 0.276 348418 DR1 Down-regulator oftranscription 1, TBP-binding (nagative cofactor 109.41 77.62 0.207349656 SCARB2 Scavenger receptor class B, member 2 147.31 89.03 0.241350194 ZMAT2 Zinc finger, matrin type 2 115.49 53.42 0.207 350229 CASC3Cancer susceptibility candidate 3 124.19 53.21 0.241 350268 IRF2BP2Interferon regulatory factor 2 binding protein 2 153.03 81.62 0.276350364 FAM120AOS Family with sequence similarity 120A opposite strand107.30 65.11 0.379 350927 SLC25A6 Solute carrier family 25(mitochondrial carrier; adenine nucleotide 952.99 85.55 0.000translocator), member 6 351099 FLJ10241 Hypothetical protein FLJ10241126.93 65.83 0.276 351296 LOC51035 SAPK substrate protein 1 210.44 71.710.172 351316 TM4SF1 Transmembrane 4 L six family member 1 422.43 110.130.276 351474 PAQR4 Progestin and adipoQ receptor family member IV 212.87153.70 0.345 351680 CDNA clone IMAGE: 5302006 133.19 88.88 0.276 351875COX6C Cytochrome c oxidase subunit VIc 304.69 180.70 0.310 352341 STCHStress 70 protein chaperone, microsome-associated, 60 kDa 121.74 86.320.379 352656 GHITM Growth hormone inducible transmembrane protein 363.9299.19 0.103 352768 PSMB1 Proteasome (prosome, macropain) subunit, betatype, 1 292.02 82.24 0.103 354056 POR P450 (cytochrome) oxidoreductase227.09 82.79 0.379 355141 TNIP1 TNFAIP3 interacting protein 1 269.8197.79 0.241 355606 TMEM167 Transmembrane protein 167 211.08 149.60 0.276355643 RNPS1 RNA binding protein S1, serine-rich domain 423.42 65.750.103 355708 TMEM127 Transmembrane protein 127 77.31 49.24 0.379 355750JOSD3 Josephin domain containing 3 117.50 61.17 0.379 355753 AGPAT61-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic 150.1373.56 0.345 acid acyltransferase, zeta) 355867 MARS Methionine-tRNAsynthetase 323.10 233.26 0.069 355927 VDAC2 Voltage-dependent anionchannel 2 242.40 82.56 0.103 355934 SFPQ Splicing factorproline/glutamine-rich (polypyrimidine tract binding 269.46 133.96 0.138protein associated) 355983 BZW1 Basic leucine zipper and W2 domains 1338.32 108.39 0.103 356061 MAP1LC3B Microtubule-associated protein 1light chain 3 beta 126.69 74.25 0.207 356096 MAP7D1 MAP7 domaincontaining 1 191.33 92.49 0.207 356190 UBB Ubiquitin B 742.69 74.990.000 356270 SDHD Succinate dehydrogenase complex, subunit D, integralmembrane 977.72 187.08 0.207 protein 356285 HMGN1 High-mobility groupnucleosome binding domain 1 279.36 80.39 0.138 356331 PPIAPeptidylprolyl isomerase A (cyclophilin A) 1225.70 78.02 0.034 356368RPS2 Ribosomal protein S2 5031.59 91.00 0.000 356371 RPL28 Ribosomalprotein L28 622.10 176.27 0.034 356377 RNF187 Ring finger protein 187188.84 96.73 0.207 356487 C19orf42 Chromosome 19 open reading frame 42148.32 80.69 0.034 356501 PHF6 PHD finger protein 6 145.65 87.04 0.310356502 RPLP1 Ribosomal protein, large, P1 881.03 208.46 0.000 356549SNRPD3 Small nuclear ribonucleoprotein D3 polypeptide 18 kDa 153.6384.17 0.276 356630 NUTF2 Nuclear transport factor 2 144.29 83.13 0.103356647 SNX6 Sorting nexin 6 134.10 84.57 0.310 356654 PSMC1 Proteasome(prosome, macropain) 26S subunit, ATPase, 1 154.97 82.94 0.172 356766C20orf199 Chromosome 20 open reading frame 199 227.51 154.61 0.310356769 MAN2B1 Mannosidase, alpha, class 2B, member 1 166.87 97.57 0.310356799 RPL41 Ribosomal protein L41 336.21 165.15 0.345 357901 SOX4 SRY(sex determining region Y)-box 4 163.64 90.74 0.345 362728 SEP15 15 kDaselenoprotein 302.87 139.54 0.138 365116 U2AF1 U2(RNU2) small nuclearRNA auxiliary factor 1 152.30 63.70 0.241 368084 LRPPRC Leucine-richPPR-motif containing 180.31 95.65 0.241 368149 CCT7 Chaperonincontaining TCP1, subunit 7 (eta) 968.98 94.04 0.069 368157 PYGBPhosphorylase, glycogen; brain 289.40 94.26 0.241 368240 DYRK1ADual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 132.3993.19 0.379 368264 PPP2R5C Protein phosphatase 2, regulatory subunit B(B56), gamma 235.30 135.72 0.103 368376 SRPR Signal recognition particlereceptor (‘docking protein’) 170.10 91.17 0.138 368402 C8orf55Chromosome 8 open reading frame 55 129.24 75.63 0.379 368404 EXT2Exostoses (multiple) 2 144.25 80.41 0.345 368525 PDLIM1 PDZ and LIMdomain 1 (elfin) 285.39 113.52 0.241 368598 ZC3H15 Zinc finger CCCH-typecontaining 15 153.03 73.26 0.172 368934 C17orf45 Chromosome 17 openreading frame 45 538.27 122.37 0.103 368985 TRIP12 Thyroid hormonereceptor interactor 12 160.59 66.50 0.345 369017 RAB2A RAB2A, member RASoncogene family 165.09 87.27 0.172 369052 SELT Selenoprotein T 368.37150.53 0.172 369068 DYNC1LI2 Dynein, cytoplasmic 1, light intermediatechain 2 158.58 97.53 0.138 369125 PSMD14 Proteasome (prosome, macropain)26S subunit, non-ATPase, 14 166.50 83.15 0.103 369285 INTS7 Integratorcomplex subunit 7 112.06 98.19 0.379 369356 MLL5 Myeloid/lymphoid ormixed-lineage leukemia 5 (trithorax homolog, 156.73 73.07 0.276Drosophila) 369606 CPSF6 Cleavage and polyadenylation specific factor 6,68 kDa 132.90 65.76 0.207 369607 GAK Cyclin G associated kinase 139.6691.16 0.379 369614 COPS2 COP9 constitutive photomorphogenic homologsubunit 2 138.58 64.46 0.241 (Arabidopsis) 369615 SLC25A38 Solutecarrier family 25, member 38 148.69 73.93 0.345 369761 DAZAP2 DAZassociated protein 2 432.10 77.51 0.069 369785 C19orf50 Chromosome 19open reading frame 50 176.53 91.76 0.207 369920 RAP1B RAP1B, member ofRAS oncogene family 160.45 86.70 0.138 370024 SEC31A SEC31 homolog A (S.cerevisiae) 162.54 73.78 0.138 370247 APLP2 Amyloid beta (A4)precursor-like protein 2 331.96 98.29 0.207 370292 BCCIP BRCA2 andCDKN1A interacting protein 116.14 69.62 0.172 370312 FNTAFarnesyltransferase, CAAX box, alpha 113.75 73.97 0.172 370408 COMTCatechol-O-methyltransferase 269.48 182.45 0.138 370581 CAP1 CAP,adenylate cyclase-associated protein 1 (yeast) 429.82 79.15 0.069 370770XPO1 Exportin 1 (CRM1 homolog, yeast) 218.71 75.18 0.172 370771 CDKN1ACyclin-dependent kinase inhibitor 1A (p21, Cip1) 406.91 129.23 0.207370895 RPN2 Ribophorin II 431.77 115.24 0.069 370927 LRRC59 Leucine richrepeat containing 59 338.69 149.06 0.138 370937 TAPBP TAP bindingprotein (tapasin) 159.24 70.81 0.310 371001 EIF3S9 Eukaryotictranslation initiation factor 3, subunit 9 eta, 116 kDa 343.76 63.640.103 371416 CARM1 Coactivator-associated arginine methyltransferase 1168.54 108.72 0.276 371563 RAB14 RAB14, member RAS oncogene family154.08 65.54 0.310 371783 C1orf77 Chromosome 1 open reading frame 77121.36 60.36 0.207 371889 ATP1A1 Hypothetical protein MGC16179 910.43156.53 0.069 372003 FAM120A Family with sequence similarity 120A 211.67121.79 0.241 372050 YIPF5 Yip1 domain family, member 5 117.56 66.390.276 372286 CUL3 Cullin 3 131.34 66.77 0.207 372331 SPTAN1 Spectrin,alpha, non-erythrocytic 1 (alpha-fodrin) 187.03 76.74 0.207 372541KBTBD2 Kelch repeat and BTB (POZ) domain containing 2 100.18 63.32 0.310372616 ARL1 ADP-ribosylation factor-like 1 107.60 50.60 0.345 372914NDRG1 N-myc downstream regulated gene 1 214.33 101.47 0.241 373550 TGIF1TGFB-induced factor homeobox 1 109.97 67.30 0.379 373741 HM13Histocompatibility (minor) 13 280.09 120.85 0.069 373763 HNRPRHeterogeneous nuclear ribonucleoprotein R 210.83 74.59 0.103 373952CAMTA2 Calmodulin binding transcription activator 2 181.38 88.37 0.345373959 VGLL4 Vestigial like 4 (Drosophila) 141.11 70.42 0.310 374043ASXL1 Additional sex combs like 1 (Drosophila) 130.97 88.31 0.241 374257LOC28616 Hypothetical protein LOC286167 151.79 112.19 0.276 374378 CKS1BCDC28 protein kinase regulatory subunit 1B 179.04 67.28 0.172 374477EWSR1 Ewing sarcoma breakpoint region 1 423.33 116.42 0.069 374503MORF4L1 Mortality factor 4 like 1 292.45 60.67 0.069 374588 RPL17Ribosomal protein L17 907.22 138.52 0.034 374596 TPT1 Tumor protein,translationally-controlled 1 987.59 77.14 0.034 374650 IFITM3 Interferoninduced transmembrane protein 3 (1-8U) 366.99 97.80 0.276 374973 PRPF4PRP4 pre-mRNA processing factor 4 homolog (yeast) 103.66 65.33 0.207375001 TLN1 Talin 1 392.09 120.61 0.138 375108 CD24 CD24 antigen (smallcell lung carcinoma cluster 4 antigen) 239.14 95.21 0.310 375217 RNF31Ring finger protein 31 104.06 73.05 0.379 376046 BTN3A2 Butyrophilin,subfamily 3, member A2 149.93 123.05 0.310 376933 GUK1 Guanylate kinase1 401.68 92.59 0.276 377155 MTDH Metadherin 214.89 91.52 0.138 378103RPS5 Ribosomal protein S5 1006.11 134.01 0.069 378532 HBS1L HBS1-like(S. cerevisiae) 131.17 80.02 0.241 378808 EIF2A Eukaryotic translationinitiation factor 2A, 65 kDa 197.55 75.77 0.138 380403 BMI1 BMI1polycomb ring finger oncogene 103.02 59.56 0.276 380774 DDX3X DEAD(Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 183.86 64.56 0.241 380953RPL38 Ribosomal protein L38 472.88 260.03 0.138 380973 SUMO2 SMT3suppressor of mif two 3 homolog 2 (yeast) 634.74 241.40 0.103 381008HLA-E Major histocompatibility complex, class I, E 476.57 108.00 0.103381058 KIAA0146 KIAA0146 protein 136.13 82.82 0.276 381072 PPIFPeptidylprolyl isomerase F (cyclophilin F) 236.14 96.10 0.034 381123RPL21 Ribosomal protein L21 1087.11 152.34 0.069 381126 RPS14 Ribosomalprotein S14 312.13 120.35 0.172 381189 CBX3 Chromobox homolog 3 (HP1gamma homolog Drosophila) 352.70 90.90 0.138 381219 RPL15 Ribosomalprotein L15 454.76 118.60 0.034 381256 GLTP Glycolipid transfer protein107.14 53.95 0.379 382044 MRPS2 Mitochondrial ribosomal protein S2171.06 80.19 0.207 382168 NCOA3 Nuclear receptor coactivator 3 166.37135.20 0.345 385913 ANP32E Acidic (leucine-rich) nuclear phosphoprotein32 family, member E 183.06 71.26 0.345 385986 UBE2BUbiquitin-conjugating enzyme E2B (RAD6 homolog) 135.72 71.52 0.345386434 ANXA7 Annexin A7 173.87 70.85 0.138 386465 CHERP Calciumhomeostasis endoplasmic reticulum protein 177.08 80.21 0.345 386939 USP7Ubiquitin specific peptidase 7 (herpes virus-associated) 181.20 217.360.207 387208 FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV)338.62 163.47 0.103 ubiquitously expressed (fox derived); ribosomalprotein S30 387804 PABPC1 Poly(A) binding protein, cytoplasmic 1 625.6887.04 0.000 388034 RXRB Retinoid X receptor, beta 142.87 89.88 0.310388654 ATP6V1G1 ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit Gisoform 1 234.65 112.64 0.172 388664 RPL11 Ribosomal protein L11 672.13137.34 0.034 388739 XRCC5 X-ray repair complementing defective repair inChinese hamster 346.39 73.79 0.034 cells 5 (double-strand-breakrejoining; Ku autoantigan, 80 kDa) 388927 YY1 YY1 transcription factor136.53 65.73 0.103 388956 C19orf22 Chromosome 19 open reading frame 22133.57 84.00 0.345 389037 MCM3APAS MCM3 minichromosome maintenancedeficient 3 (S. cerevisiae) 152.46 115.81 0.207 associated protein389107 ATP6V0C ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c237.34 79.84 0.172 389171 PINK1 PTEN induced putative kinase 1 126.4498.97 0.207 389649 EIF4A3 Eukaryotic translation initiation factor 4A,isoform 3 193.85 75.13 0.138 389734 TCEAL8 Transcription elongationfactor A (SII)-like 8 155.08 72.63 0.345 389996 CHCHD2Colied-coli-helix-coiled-coil-helix domain containing 2 373.11 68.470.034 390667 GSTK1 Glutathione S-transferase kappa 1 168.35 104.34 0.241393201 ACTR2 ARP2 actin-related protein 2 homolog (yeast) 328.49 139.010.172 395482 PTK2 PTK2 protein tyrosine kinase 2 177.88 103.98 0.207396644 PAIP2 Poly(A) binding protein interacting protein 2 198.13 69.250.103 396740 NIP30 NEFA-interacting nuclear protein NIP30 96.64 53.080.241 396783 SLC9A3R1 Solute carrier family 9 (sodium/hydrogenexchanger), member 3 165.70 98.11 0.276 regulator 1 397609 RPS16Ribosomal protein S16 1470.38 224.21 0.069 399800 AKAP8L A kinase (PRKA)anchor protein 8-like 166.62 90.19 0.310 400295 RPL30 Ribosomal proteinL30 473.07 139.61 0.103 401509 RBM10 RNA binding motif protein 10 170.0575.56 0.172 401903 COX5A Cytochrome c oxidase subunit Va 149.97 93.760.379 401929 RPL10 Ribosomal protein L10 1521.64 147.31 0.000 403917STK24 Serine/threonine kinase 24 (STE20 homolog, yeast) 150.48 64.520.276 404056 EIF3S1 Eukaryotic translation initiation factor 3, subunit1 alpha, 35 kDa 140.93 90.80 0.310 404321 GARS Glycyl-tRNA synthetase247.29 80.31 0.034 405144 SFRS3 Splicing factor, arginine/serine-rich 3526.80 137.87 0.034 405410 OGT O-linked N-acetylglucosamine (GlcNAc)transferase (UDP-N- 153.55 55.45 0.379acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 405514KIAA1267 KIAA1267 114.08 65.11 0.345 405590 EIF3S6 Eukaryotictranslation initiation factor 3, subunit 6 48 kDa 654.44 113.72 0.069405880 MRPS21 Mitochondrial ribosomal protein S21 141.88 82.93 0.276405942 CCDC137 Coiled-coil domain containing 137 133.03 86.11 0.241406062 NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11,14.7 kDa 173.17 93.80 0.345 406068 UBE2M Ubiquitin-conjugating enzymeE2M (UBC12 homolog, yeast) 132.46 80.88 0.345 406096 ZFAND5 Zinc finger,AN1-type domain 5 192.43 93.38 0.345 406277 SF3A1 Splicing factor 3a,subunit 1, 120 kDa 296.74 89.39 0.276 406300 RPL23 Ribosomal protein L23696.30 308.79 0.069 406423 SF3B2 Splicing factor 3b, subunit 2, 145 kDa355.96 73.17 0.069 406510 ATP5B ATP synthase, H+ transporting,mitochondrial F1 complex, beta 1002.07 88.90 0.034 polypeptide 406520LOC38954 Similar to CG14977-PA 124.27 87.28 0.276 406534 HMG20BHigh-mobility group 20B 281.92 155.98 0.103 406590 MRFAP1 Mof4 familyassociated protein 1 256.02 73.95 0.207 406620 RPS10 Ribosomal proteinS10 1185.80 153.87 0.034 406683 RPS15 Ribosomal protein S15 521.25123.23 0.069 406799 RAB18 RAB18, member RAS oncogene family 127.87 57.580.310 406840 SLC35A4 Solute carrier family 35, member A4 186.45 71.300.103 407368 LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 151.28 68.770.207 407580 PKP4 Plakophilin 4 130.61 101.53 0.207 407995 MIFMacrophage migration inhibitory factor (glycosylation-inhibiting 520.62161.06 0.241 factor) 408018 RPL36 Ribosomal protein L36 426.58 200.200.276 408073 RPS6 Ribosomal protein S6 1753.93 92.01 0.034 408236 TXNL5Thioredoxin-like 5 137.51 78.57 0.276 408257 NDUFS6 NADH dehydrogenase(ubiquinone) Fe—S protein 6, 13 kDa 167.98 115.41 0.379 (NADH-coenzyme Qreductase) 408293 CEP170 Centrosomal protein 170 kDa 95.55 57.63 0.379408324 FLJ10769 Hypothetical protein FLJ10769 179.63 110.86 0.345 408428FOXN3 Forkhead box N3 171.98 93.85 0.379 408581 SVIL Supervillin 150.7978.33 0.276 408909 GOLPH3 Golgi phosphoprotein 3 (coat-protein) 149.5590.99 0.207 409140 ATP5O ATP synthase, H+ transporting, mitochondrial F1complex, O 238.76 77.50 0.138 subunit (oligomycin sensitivity conferringprotein) 409223 SSR4 Signal sequence receptor, delta(translocon-associated protein 187.19 88.00 0.138 delta) 409230 AGPAT11-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic 188.8378.43 0.207 acid acyltransferase, alpha) 409834 PHPT1 Phosphohistidinephosphatase 1 129.72 80.15 0.379 410197 IDH3G Isocitrate dehydrogenase 3(NAD+) gamma 142.89 74.63 0.276 410596 WDR68 WD repeat domain 68 190.3978.19 0.069 410817 RPL13 Ribosomal protein L13 1259.59 96.20 0.034411480 AUP1 Ancient ubiquitous protein 1 197.34 72.07 0.103 411641EIF4EBP1 Eukaryotic translation initiation factor 4E binding protein 1185.54 87.93 0.310 411847 MAPK6 Mitogen-activated protein kinase 6143.89 100.65 0.207 412103 EFHA1 EF-hand domain family, member A1 130.6968.19 0.276 412117 ANXA6 Annexin A6 173.96 90.66 0.172 412196 IFT57Intraflagellar transport 57 homolog (Chlamydomonas) 109.98 56.91 0.379412433 AIP Aryl hydrocarbon receptor interacting protein 157.20 76.870.207 412468 KLHDC3 Kelch domain containing 3 366.49 77.49 0.172 412842CDC123 Cell division cycle 123 homolog (S. cerevisiae) 155.00 62.200.207 413036 WBSCR22 Williams Beuren syndrome chromosome region 22181.29 80.06 0.103 413482 C21orf33 Chromosome 21 open reading frame 33220.73 103.88 0.172 414579 SCOTIN Scotin 344.80 79.60 0.138 415342 TCF25Transcription factor 25 (basic helix-loop-helix) 132.99 67.57 0.172416049 TNPO2 Transportin 2 (importin 3, karyopherin beta 2b) 121.8074.72 0.345 416436 TRIM50 Tripartite motif-containing 50 253.97 118.360.138 417004 S100A11 S100 calcium binding protein A11 (calgizzarin)282.02 146.47 0.138 417029 C17orf81 Chromosome 17 open reading frame 81116.93 60.21 0.379 418123 CTSLL3 Cathepsin L-like 3 196.99 151.69 0.345418175 VPS28 Vacuolar protein sorting 28 (yeast) 137.80 101.08 0.345418233 MRPL24 Mitochondrial ribosomal protein L24 111.66 117.93 0.345418450 MRPL11 Mitochondrial ribosomal protein L11 169.41 63.02 0.310418533 BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)180.32 113.91 0.172 418668 ATP5D ATP synthase, H+ transporting,mitochondrial F1 complex, delta 142.90 94.88 0.276 subunit 419640 PARK7Parkinson disease (autosomal recessive, early onset) 7 255.09 75.950.172 420269 COL6A2 Collagen, type VI, alpha 2 425.15 132.41 0.379420272 H2AFY H2A histone family, member Y 238.54 78.85 0.069 421257 RPL7Ribosomal protein L7 148.01 111.08 0.138 421509 CCT4 Chaperonincontaining TCP1, subunit 4 (delta) 245.54 69.17 0.138 422113 ZNF511 Zincfinger protein 511 92.03 40.84 0.379 423935 RDBP RD RNA binding protein114.07 56.49 0.241 423968 FIS1 Fission 1 (mitochondrial outer membrane)homolog (S. cerevisiae) 140.14 94.84 0.379 424126 SERF2 Small EDRK-richfactor 2 421.90 169.35 0.103 424908 LSM5 LSM5 homolog, U6 small nuclearRNA associated (S. cerevisiae) 118.18 94.48 0.310 425777 UBE2L6Ubiquitin-conjugating enzyme E2L 6 176.08 83.76 0.345 426296 C10orf104Chromosome 10 open reading frame 104 193.46 94.72 0.207 426359 PRR13proline rich 13 204.04 77.90 0.345 429052 ITGB1 Integrin, beta 1(fibronectin receptor, beta polypeptide, antigen 343.25 71.08 0.207 CD29includes MDF2, MSK12) 429353 SEPN1 Selenoprotein N, 1 163.54 91.46 0.241429581 RTN4 Reticulon 4 587.74 263.68 0.069 429819 PITPNAPhosphatidylinositol transfer protein, alpha 132.54 66.33 0.241 429839BTF3L4 Basic transcription factor 3-like 4 128.62 88.13 0.379 430425GNB1 Guanine nucleotide binding protein (G protein), beta polypeptide 1348.68 72.19 0.069 430551 IQGAP1 IQ motif containing GTPase activatingprotein 1 168.69 68.30 0.241 430606 CS Citrate synthase 377.31 109.460.034 430657 ARF5 ADP-ribosylation factor 5 184.36 99.34 0.310 430733CLNS1A Chloride channel, nucleotide-sensitive, 1A 147.58 71.03 0.207431101 GNG12 Guanine nucleotide binding protein (G protein), gamma 12197.95 72.99 0.310 431367 VTA1 Vps20-associated 1 homolog (S.cerevisiae) 154.26 81.47 0.172 431498 FOXP1 Forkhead box P1 158.95 84.080.345 431550 MAP4K4 Mitogen-activated protein kinase kinase kinasekinase 4 150.49 75.85 0.241 431668 COX6B1 Cytochrome c oxidase subunitVib polypeptide 1 (ubiquitous) 249.30 171.30 0.207 431850 MAPK1Mitogen-activated protein kinase 1 147.43 68.90 0.241 431861 PPP5CProtein phosphatase 5, catalytic subunit 203.35 97.62 0.138 431926 NFKB1Nuclear factor of kappa light polypeptide gene enhancer in B-cells118.70 65.79 0.310 1 (p105) 432121 PRDX2 Peroxiredoxin 2 328.05 98.460.069 432438 EML4 Echinoderm microtubule associated protein like 4127.17 67.00 0.345 432491 ESD Esterase D/formylglutathione hydrolase181.49 81.57 0.103 432690 SLC39A9 Solute carrier family 39 (zinctransporter), member 9 123.27 74.29 0.207 432760 CAPZB Capping protein(actin filament) muscle Z-line, beta 189.76 70.34 0.069 432898 RPL4Mitogen-activated protein kinase kinase kinase 13 2173.97 96.68 0.000432976 NR1H2 Nuclear receptor subfamily 1, group H, member 2 190.02112.04 0.241 433154 PLSCR3 Phospholipid scramblase 3 118.46 78.13 0.345433201 CDK2AP1 CDK2-associated protein 1 137.33 80.77 0.241 433222 NPC2Niemann-Pick disease, type C2 218.82 98.64 0.069 433291 ARD1A ARD1homolog A, N-acetyltransferase (S. cerevisiae) 119.07 75.05 0.207 433307BCKDHA Branched chain keto acid dehydrogenase E1, alpha polypeptide166.35 84.74 0.379 (maple syrup urine disease) 433343 SRRM2Serine/arginine repetitive matrix 2 179.81 99.94 0.103 433345Full-length cDNA clone CL0BB014ZH04 of Neuroblastoma of 131.69 72.430.241 Homo sapiens (human) 433419 COX4I1 Cytochrome c oxidase subunit IVisoform 1 291.96 97.81 0.103 433512 ACTR3 ARP3 actin-related protein 3homolog (yeast) 202.84 72.82 0.103 433529 RPS11 Ribosomal protein S11659.56 130.65 0.069 433540 DNAJC8 DnaJ (Hsp40) homolog, subfamily C,member 8 164.57 66.59 0.172 433573 C11orf68 Chromosome 11 open readingframe 68 109.74 74.58 0.379 433615 TUBB2C Tubulin, beta 2C 1313.99109.59 0.034 433701 RPL37A Ribosomal protein L37a 941.22 280.38 0.034433722 KIAA1967 KIAA1967 137.26 57.51 0.345 433732 CLK1 CDC-like kinase1 179.68 71.24 0.379 433750 EIF4G1 Eukaryotic translation initiationfactor 4 gamma, 1 509.92 79.20 0.138 433759 BANF1 Barrier toautointegration factor 1 185.36 115.51 0.103 433795 SHC1 SHC (Srchomology 2 domain containing) transforming protein 1 307.01 110.48 0.103433863 PEBP1 Phosphatidylethanolamine binding protein 1 349.44 89.200.034 433901 COX8A Cytochrome c oxidase subunit 8A (ubiquitous) 335.34202.06 0.207 433951 GPX4 Glutathione peroxidase 4 (phospholipidhydroperoxidase) 265.60 84.94 0.207 434102 HMGB1 High-mobility group box1 638.86 104.01 0.000 434207 HARS2 Histidyl-tRNA synthetase 2 146.7694.43 0.276 434219 ANKHD1 Ankyrin repeat and KH domain containing 1190.31 76.42 0.103 434401 ZNF638 Zinc finger protein 638 127.61 80.050.276 434937 PPIB Peptidylprolyl isomerase B (cyclophilin B) 258.1278.54 0.069 434953 HMGB2 High-mobility group box 2 275.63 95.40 0.138434980 APP Amyloid beta (A4) precursor protein (peptidase nexin-II,Alzheimer 228.56 92.10 0.172 disease) 435044 TBC1D22A TBC1 domainfamily, member 22A 160.02 137.97 0.310 435064 DENND1A DENN/MADD domaincontaining 1A 99.58 55.26 0.379 435120 KIF1C Kinesin family member 1C210.09 68.46 0.241 435136 TXN Thioredoxin 346.61 189.66 0.276 435166 LBRLamin B receptor 188.22 185.85 0.310 435231 ZFR Zinc finger RNA bindingprotein 158.35 73.83 0.172 435255 UBXD1 UBX domain containing 1 173.66118.04 0.241 435326 ACTL6A Actin-like 6A 152.42 64.63 0.172 435512PPP3CA Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha156.63 85.19 0.345 isoform (calcineurin A alpha) 435535 ZNF395 Zincfinger protein 395 126.06 79.68 0.310 435610 WAC WW domain containingadaptor with coiled-coil 197.21 111.45 0.172 435741 GCSH IQ motif and WDrepeats 1 165.11 72.41 0.138 435759 THAP4 THAP domain containing 4133.58 83.98 0.379 435771 API5 Apoptosis inhibitor 5 191.29 106.97 0.276435841 TNRC15 Trinucleotide repeat containing 15 115.02 60.28 0.310435850 LYPLA1 Lysophospholipase I 278.94 96.93 0.138 435933 PHF10Chromosome 6 open reading frame 120 160.27 71.75 0.276 435948 ATAD1ATPase family, AAA domain containing 1 119.77 79.07 0.310 435952CDK5RAP1 CDK5 regulatory subunit associated protein 1 122.11 83.77 0.310435974 MTHFD1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent)1, 193.28 103.81 0.172 methenyltetrahydrofolate cyclohydrolase,formyltetrahydrofolate synthetase 436035 TUBA1C Tubulin, alpha 1c3419.68 98.12 0.000 436093 BAT2 HLA-B associated transcript 2 414.3596.65 0.172 436204 ZNF289 Zinc finger protein 289, ID1 regulated 187.4870.10 0.138 436298 EMP1 Epithelial membrane protein 1 139.81 90.61 0.310436405 IDH3B Isocitrate dehydrogenase 3 (NAD+) beta 233.17 64.64 0.172436437 ALDH2 Aldehyde dehydrogenase 2 family (mitochondrial) 213.9991.66 0.207 436446 ARMET Arginine-rich, mutated in early stage tumors238.76 107.79 0.379 436500 DBNL Drebrin-like 322.18 106.61 0.241 436568CD74 CD74 antigen (invariant polypeptide of major histocompatibility3672.46 211.82 0.345 complex, class II antigen-associated) 436578 POLR2FPolymerase (RNA) II (DNA directed) polypeptide F 106.90 73.50 0.345436657 CLU Clusterin (complement lysis inhibitor, SP-40,40, sulfated586.91 158.76 0.241 glycoprotein 2, testosterone-repressed prostatemessage 2, apolipoprotein J) 436687 SET SET translocation (myeloidleukemia-associated) 285.02 84.84 0.034 436803 VBP1 Von Hippel-Lindaubinding protein 1 182.84 93.52 0.207 437056 SUPT5H Suppressor of Ty 5homolog (S. cerevisiae) 216.64 117.71 0.207 437060 CYCS Cytochrome c,somatic 1874.90 252.41 0.207 437110 ANXA2 Annexin A2 2060.10 130.610.034 437178 ACADVL Acyl-Coenzyme A dehydrogenase, very long chain288.37 92.69 0.069 437256 GRINL1A Glutamate receptor, ionotropic,N-methyl D-aspartate-like 1A 151.07 83.14 0.345 437277 MGAT4B Mannosyl(alpha-1,3-)-glycoprotein beta-1,4-N- 1083.50 147.46 0.103acetylglucosaminyltransferase, isoenzyme B 437367 GBAS Glioblastomaamplified sequence 143.22 113.71 0.276 437388 PIGT Phosphatidylinositolglycan, class T 227.91 106.45 0.103 437403 PPA1 Pyrophosphatase(inorganic) 1 159.06 72.02 0.138 437594 RPLP2 Ribosomal protein, large,P2 498.18 148.73 0.034 437638 XBP1 X-box binding protein 1 319.21 100.780.069 437779 C11orf10 Chromosome 11 open reading frame 10 241.39 149.440.345 437831 C14orf32 Chromosome 14 open reading frame 32 175.37 74.130.241 438072 UNC84A Unc-84 homolog A (C. elegans) 146.52 82.20 0.345438219 GPS2 G protein pathway suppressor 2 172.78 109.64 0.172 438429RPS19 Ribosomal protein S19 721.53 169.75 0.103 438678 TALDO1Transaldolase 1 280.29 75.06 0.138 438720 MCM7 MCM7 minichromosomemaintenance deficient 7 (S. cerevisiae) 548.49 107.89 0.138 438970TBL1XR1 Transducin (beta)-like 1X-linked receptor 1 185.70 86.87 0.241438974 CUTL1 Cut-like 1, CCAAT displacement protein (Drosophila) 159.6595.91 0.310 439480 RBM5 RNA binding motif protein 5 145.24 117.34 0.379439481 SUPT4H1 Suppressor of Ty 4 homolog 1 (S. cerevisiae) 139.55 62.120.207 439548 FAM96A Family with sequence similarity 96, member A 155.3585.61 0.241 439552 MAP2K3 Mitogen-activated protein kinase kinase 32617.77 147.47 0.000 439815 HBXIP Hepatitis B virus x interactingprotein 127.08 97.39 0.310 440382 TRIM27 Tripartite motif-containing 27155.33 68.54 0.172 440544 CLIC4 Chloride intracellular channel 4 337.71121.54 0.103 440599 DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 433.83283.30 0.103 440604 PSMD7 Proteasome (prosome, macropain) 26S subunit,non-ATPase, 7 156.07 77.17 0.138 (Mov34 homolog) 440899 TTYH3 Tweetyhomolog 3 (Drosophila) 229.54 97.64 0.172 440932 SEPT9 Septin 9 361.7896.86 0.034 440960 RAD23A RAD23 homolog A (S. cerevisiae) 214.38 69.610.207 440961 CAST Calpastatin 194.31 90.01 0.207 441072 POLR2LPolymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa 225.44 138.680.379 441550 ABHD12 Abhydrolase domain containing 12 215.47 106.70 0.241442344 IRS2 Insulin receptor substrate 2 134.97 79.52 0.379 442798 RNF10Ring finger protein 10 210.73 75.43 0.103 443134 GBA2 Glucosidase, beta(bile acid) 2 132.85 60.27 0.379 443379 PSMD11 Proteasome (prosome,macropain) 26S subunit, non-ATPase, 11 180.98 64.45 0.172 443837 NPEPPSAminopeptidase puromycin sensitive 173.54 73.65 0.172 443914 SOD1Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 341.0688.95 0.103 (adult)) 444279 GPBP1 GC-rich promoter binding protein 1132.98 56.92 0.241 444356 GRB2 Growth factor receptor-bound protein 2167.92 61.94 0.172 444468 CTDSP1 CTD (carboxy-terminal domain, RNApolymerase II, polypeptide A 187.59 76.37 0.241 small phosphatase 1444472 SDHC Succinate dehydrogenase complex, subunit C, integralmembrane 175.42 71.22 0.207 protein, 15 kDa 444569 TMEM49 Transmembraneprotein 49 212.58 83.31 0.241 444673 CLPTM1L CLPTM1-like 229.08 106.760.207 444724 AZI2 5-azacytidine induced 2 132.28 73.71 0.345 444818CGGBP1 CGG triplet repeat binding protein 1 177.53 83.72 0.241 444931CRSP6 Cofactor required for Sp1 transcriptional activation, subunit 6,77 kDa 88.71 48.78 0.379 444969 MEMO1 Mediator of cell motility 1 96.5259.19 0.276 444986 METAP2 Methionyl aminopeptidase 2 169.09 73.08 0.172445081 OAF OAF homolog (Drosophila) 113.21 58.71 0.345 445351 LGALS1Lectin, galactoside-binding, soluble, 1 (galectin 1) 564.16 197.93 0.241445394 VPS29 Vacuolar protein sorting 29 (yeast) 278.97 108.32 0.138445498 SNW1 SNW domain containing 1 143.71 69.55 0.138 445511 RIOK3 RIOkinase 3 (yeast) 110.92 105.70 0.379 445570 CD63 CD63 antigen (melanoma1 antigen) 489.45 199.49 0.034 445803 DC2 DC2 protein 658.16 215.090.138 445893 KHDRBS1 KH domain containing, RNA binding, signaltransduction 227.64 88.75 0.138 associated 1 445977 GTF3A Generaltranscription factor IIIA 160.66 73.81 0.172 446017 WSB1 WD repeat andSOCS box-containing 1 239.91 93.71 0.276 446091 WTAP Wilms tumor 1associated protein 119.70 95.46 0.379 446123 CAPZA2 Capping protein(actin filament) muscle Z-line, alpha 2 370.83 95.48 0.138 446149 LDHBLactate dehydrogenase B 1544.78 120.53 0.000 446260 PSMA6 Proteasome(prosome, macropain) subunit, alpha type, 6 224.07 106.72 0.172 446336PXN Paxillin 259.56 97.96 0.138 446345 FTH1 Ferritin, heavy polypeptide1 2359.77 133.58 0.034 446414 CD47 CD47 antigen (Rh-related antigen,integrin-associated signal 165.59 95.67 0.310 transducer) 446427 OAZ1Ornithine decarboxylase antizyme 1 673.68 62.71 0.069 446445 YIF1A Yip1interacting factor homolog A (S. cerevisiae) 151.87 80.99 0.276 446450ITM2B Integral membrane protein 2B 511.62 115.21 0.138 446574 TMSB10Thymosin beta 10 524.43 177.08 0.103 446588 RPS13 Ribosomal protein S13183.34 95.13 0.345 446623 HNRPL Heterogeneous nuclear ribonucleoproteinL 113.61 53.54 0.276 446628 RPS4X Ribosomal protein S4, X-linked 1285.0689.84 0.000 446641 ARAF V-raf murine sarcoma 3611 viral oncogene homolog176.49 69.57 0.241 446852 EIF3S6IP Eukaryotic translation initiationfactor 3, subunit 6 interacting 925.97 188.87 0.034 protein 447477 ST13Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 272.29 141.170.103 interacting protein) 447492 PGAM1 Phosphoglycerate mutase 1(brain) 781.46 84.70 0.034 447547 VPS35 Hypothetical protein MGC34800195.14 67.15 0.103 448226 RPLP0 Ribosomal protein, large, P0 3809.2075.92 0.000 448588 NGFRAP1 Nerve growth factor receptor (TNFRSF16)associated protein 1 218.09 83.14 0.310 448646 RPL27A Ribosomal proteinL27a 766.60 139.37 0.276 448879 LOC38834 similar to ribosomal proteinL13 471.24 99.11 0.069 449114 HNRPC Heterogeneous nuclearribonucleoprotein C (C1/C2) 803.24 90.38 0.034 449171 HNRPKHeterogeneous nuclear ribonucleoprotein K 403.79 69.90 0.034 454534 USF2Upstream transcription factor 2, c-fos interacting 111.98 76.53 0.310454699 IL6ST Interleukin 6 signal transducer (gp130, oncostatin Mreceptor) 266.74 139.73 0.103 456507 KIAA0319L KIAA0319-like 131.4585.77 0.241 456557 C1orf164 chromosome 1 open reading frame 164 143.8971.60 0.276 458320 C3orf37 chromosome 3 open reading frame 37 170.49148.07 0.310 458358 TSPYL1 Squamous cell carcinoma antigen recognized byT cells 2 101.91 73.81 0.345 458414 IFITM1 Interferon inducedtransmembrane protein 1 (9-27) 278.31 223.88 0.345 458458 FAM108A1Family with sequence similarity 108, member A1 149.77 96.59 0.276 458747ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A197.57 100.71 0.172 459106 AZIN1 Antizyme inhibitor 1 209.63 95.22 0.207459149 BTBD1 BTB (POZ) domain containing 1 136.20 84.67 0.310 459174FAM91A1 Family with sequence similarity 91, member A1 133.90 80.72 0.379459211 AKAP13 A kinase (PRKA) anchor protein 13 217.52 97.30 0.310459596 MPG N-methylpurine-DNA glycosylase 110.09 94.77 0.241 459649CLCN7 Chloride channel 7 161.09 107.31 0.207 459927 PTMA Prothymosin,alpha (gene sequence 28) 1066.55 86.69 0.000 459940 LITAFLipopolysaccharide-induced TNF factor 184.70 98.75 0.069 460238 SH3GLB2SH3-domain GRB2-like endophilin B2 146.60 86.41 0.207 460317 SETXSenataxin 132.56 111.94 0.310 460336 GGA2 Golgi associated, gammaadaptin ear containing, ARF binding 253.27 171.03 0.241 protein 2 460468XPO6 Exportin 6 212.84 80.39 0.172 460499 ATXN2L Ataxin 2-like 228.2584.67 0.310 460574 LOC12444 Hypothetical protein BC017488 125.84 87.370.379 460923 CNOT1 CCR4-NOT transcription complex, subunit 1 173.8565.75 0.207 460929 GOT2 Glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate 397.62 79.42 0.103 aminotransferase 2) 460978APPBP1 Amyloid beta precursor protein binding protein 1 133.67 64.710.241 461047 G6PD Glucose-6-phosphate dehydrogenase 274.16 130.32 0.207461131 CYB5B Cytochrome b5 type B (outer mitochondrial membrane) 192.3075.56 0.138 461361 CFDP1 Craniofacial development protein 1 111.79 67.730.310 461379 GABARAPL2 GABA(A) receptor-associated protein-like 2 122.5563.48 0.345 461722 TRAPPC2L Trafficking protein particle complex 2-like97.91 62.09 0.379 461777 CHMP1A Chromatin modifying protein 1A 171.3177.92 0.207 461896 CRK V-crk sarcoma virus CT10 oncogene homolog (avian)158.10 68.61 0.276 461925 RPA1 Replication protein A1, 70 kDa 160.1372.42 0.103 462035 UBE2G1 Ubiquitin-conjugating enzyme E2G1 (UBC7homolog, yeast) 149.46 102.82 0.207 462086 RPAIN RPA interacting protein129.54 77.35 0.379 462306 UBE2S Ubiquitin-conjugating enzyme E2S 216.5474.27 0.310 462316 TTC19 Hypothetical protein LOC125150 116.49 89.170.241 462492 USP22 Ubiquitin specific peptidase 22 379.95 165.78 0.138462550 PIGS Phosphatidylinositol glycan, class S 164.57 97.00 0.345462956 PPARBP PPAR binding protein 106.51 76.59 0.379 462998 IGFBP4Insulin-like growth factor binding protein 4 345.88 87.71 0.207 463010SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of173.85 56.13 0.069 chromatin, subfamily e, member 1 463035 FKBP10 FK506binding protein 10, 65 kDa 164.51 91.24 0.310 463041 REREArginine-glutamic acid dipeptide (RE) repeats 200.18 92.99 0.276 463059STAT3 Signal transducer and activator of transcription 3 (acute-phase205.74 114.93 0.207 response factor) 463295 CDC27 Cell division cycle 27115.34 79.50 0.310 463506 AKAP1 A kinase (PRKA) anchor protein 1 124.1152.64 0.345 463702 BCAS3 Breast carcinoma amplified sequence 3 98.8874.57 0.379 463797 MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 142.2059.85 0.276 464071 PGD Phosphogluconate dehydrogenase 338.78 85.70 0.138464137 ACOX1 Acyl-Coenzyme A oxidase 1, palmitoyl 103.04 66.74 0.241464210 SYNGR2 Synaptogyrin 2 348.69 97.83 0.276 464336 P4HBProcollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4- 859.7489.54 0.069 hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1) 464438 AGTRAP Angiotensin II receptor-associated protein117.55 68.62 0.379 464472 MRLC2 Myosin regulatory light chain MRLC2233.35 102.50 0.034 464595 PPP4R1 Protein phosphatase 4, regulatorysubunit 1 181.18 80.16 0.241 464652 TNFSF5IP1 Tumor necrosis factorsuperfamily, member 5-induced protein 1 145.59 119.46 0.345 464912 P15RSHypothetical protein FLJ10656 142.03 83.19 0.276 465224 NARSAsparaginyl-tRNA synthetase 220.96 70.84 0.103 465374 EFHD2 EF-handdomain family, member D2 265.91 113.85 0.241 465498 TXNL4AThioredoxin-like 4A 121.61 80.29 0.276 465529 MIDN Midnolin 139.65 96.070.345 465543 BTBD2 BTB (POZ) domain containing 2 204.49 98.92 0.207465627 MAP2K2 Mitogen-activated protein kinase kinase 2 154.59 85.810.310 465645 C19orf10 Chromosome 19 open reading frame 10 204.93 79.480.276 465808 HNRPM Heterogeneous nuclear ribonucleoprotein M 258.9599.76 0.103 465849 PIN1 Protein (peptidyl-prolyl cis/trans isomerase)NIMA-interacting 1 121.36 61.35 0.310 465924 SDHB Succinatedehydrogenase complex, subunit B, iron sulfur (lp) 161.79 65.94 0.241466044 PKN1 Protein kinase N1 252.31 87.50 0.276 466088 TPM4 Tropomyosin4 139.00 71.29 0.345 466148 NR2F6 Nuclear receptor subfamily 2, group F,member 6 179.12 94.04 0.379 466471 GPI Glucose phosphate isomerase502.15 94.80 0.069 466693 SIRT2 Sirtuin (silent mating type informationregulation 2 homolog) 2 (S. cerevisiae) 214.11 113.63 0.379 466766 LTBP4Latent transforming growth factor beta binding protein 4 174.46 77.330.379 466775 SNRPA Small nuclear ribonucleoprotein polypeptide A 196.9463.74 0.138 467084 EIF4G3 Eukaryotic translation initiation factor 4gamma, 3 102.77 64.71 0.310 467097 SNRP70 Small nuclearribonucleoprotein 70 kDa polypeptide (RNP antigen) 294.48 80.04 0.103467192 PPP2R1A Protein phosphatase 2 (formerly 2A), regulatory subunit A(PR 65) 475.55 80.67 0.069 alpha isoform 467279 LENG4 Leukocyte receptorcluster (LRC) member 4 315.24 116.72 0.310 467284 RPS9 Ribosomal proteinS9 986.04 73.58 0.069 467408 TRIM28 Tripartite motif-containing 28715.33 79.78 0.138 467637 CDC42 Cell division cycle 42 (GTP bindingprotein, 25 kDa) 158.07 97.05 0.138 467696 HPCAL1 Hippocalcin-like 1172.64 83.71 0.379 467701 ODC1 Ornithine decarboxylase 1 351.16 77.300.103 467807 LAPTM4A Lysosomal-associated protein transmembrane 4 alpha482.50 88.89 0.069 467824 PUM2 Pumilio homolog 2 (Drosophila) 153.2686.50 0.207 467960 RAB10 RAB10, member RAS oncogene family 162.79 57.310.103 468018 PPP1CB Protein phosphatase 1, catalytic subunit, betaisoform 203.84 64.65 0.207 468415 PIGF Phosphatidylinositol glycan,class F 150.01 71.46 0.241 468442 CALM2 Calmodulin 2 (phosphorylasekinase, delta) 1841.31 235.41 0.000 468760 AFTPH Aftiphilin 93.25 61.520.310 469022 DGUOK Deoxyguanosine kinase 116.26 75.71 0.241 469171C1orf160 Chromosome 1 open reading frame 160 116.05 66.17 0.172 469331STARD7 START domain containing 7 312.84 91.19 0.138 469820 RALB V-ralsimian leukemia viral oncogene homolog B (ras related; GTF 125.95 59.650.379 binding protein) 469863 YWHAZ Tyrosine 3-monooxygenase/tryptophan5-monooxygenase 385.89 74.53 0.034 activation protein, zeta polypeptide469925 FAM128B Family with sequence similarity 128, member B 157.8162.74 0.345 469970 SFRS4 Splicing factor, arginine/serine-rich 4 134.1354.16 0.310 470091 YWHAE Tyrosine 3-monooxygenase/tryptophan5-monooxygenase 330.87 97.70 0.069 activation protein, epsilonpolypeptide 470233 ARL5A ADP-ribosylation factor-like 5A 137.43 81.250.345 470417 PEF1 Penta-EF-hand domain containing 1 144.07 63.57 0.241470477 PTP4A2 Protein tyrosine phosphatase type IVA, member 2 163.4569.99 0.103 470577 EIF2S2 Eukaryotic translation initiation factor 2,subunit 2 beta, 38 kDa 175.54 98.23 0.379 470588 KPNA6 Karyopherin alpha6 (importin alpha 7) 105.07 66.63 0.207 470943 STAT1 Signal transducerand activator of transcription 1, 91 kDa 204.00 91.39 0.207 471011 SF3B1Splicing factor 3b, subunit 1, 155 kDa 171.22 65.74 0.276 471104NOP5/NOP58 Nucleolar protein NOP5/NOP58 119.95 77.84 0.207 471207 NDUFS1NADH dehydrogenase (ubiquinone) Fe—S protein 1, 75 kDa 152.75 64.260.207 (NADH-coenzyme Q reductase) 471441 PSMB2 Proteasome (prosome,macropain) subunit, beta type, 2 160.02 84.75 0.207 471461 ACSL3Acyl-CoA synthetase long-chain family member 3 143.25 48.15 0.207 471593CAB39 Calcium binding protein 39 125.47 90.94 0.276 471768 STK40Serine/threonine kinase 40 150.57 81.43 0.310 471818 CAPRIN1 Cell cycleassociated protein 1 233.39 93.24 0.069 471851 HDLBP High densitylipoprotein binding protein (vigilin) 770.41 90.63 0.034 471873 DTYMKDeoxythymidylate kinase (thymidylate kinase) 151.55 81.98 0.276 471933FKBP1A FK506 binding protein 1A, 12 kDa 284.05 83.21 0.138 471975C20orf116 Chromosome 20 open reading frame 116 168.09 95.60 0.379 472010PRNP Prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann- 151.2282.78 0.276 Strausler-Scheinker syndrome, fatal familial insomnia)472024 C20orf30 Chromosome 20 open reading frame 30 180.50 82.62 0.138472031 UBE2D3 Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)305.38 72.17 0.069 472038 UTP11L UTP11-like, U3 small nucleolarribonucleoprotein, (yeast) 116.49 107.41 0.379 472056 SYNCRIPSynaptotagmin binding, cytoplasmic RNA interacting protein 198.01 71.240.103 472119 MKKS McKusick-Kaufman syndrome 110.70 82.99 0.276 472185NDUFS5 NADH dehydrogenase (ubiquinone) Fe—S protein 5, 15 kDa 317.85115.06 0.172 (NADH-coenzyme Q reductase) 472213 RRBP1 Ribosome bindingprotein 1 homolog 180 kDa (dog) 194.55 81.99 0.276 472330 C20orf3Chromosome 20 open reading frame 3 210.62 71.28 0.345 472475 MACF1Glycine-rich protein (GRP3S) 170.84 81.77 0.310 472535 AURKAIP1 Aurorakinase A interacting protein 1 236.28 92.32 0.345 472558 ERGIC3 ERGICand golgi 3 273.22 82.09 0.138 472651 BLCAP Bladder cancer associatedprotein 174.08 74.85 0.241 472737 TOP1 Topoisomerase (DNA) I 145.0771.88 0.310 473296 TPD52L2 Tumor protein D52-like 2 198.42 74.39 0.172473583 YBX1 Y box binding protein 1 706.53 98.38 0.034 473648 GARTPhosphoribosylglycinamide formyltransferase, 159.98 70.49 0.138phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazolesynthetase 473721 SLC2A1 Solute carrier family 2 (facilitated glucosetransporter), member 1 496.75 142.19 0.345 473761 RTN3 Reticulon 3222.45 76.58 0.103 473788 OTUB1 OTU domain, ubiquitin aldehyde binding 1235.08 75.48 0.207 474005 SUMO3 SMT3 suppressor of mif two 3 homolog 3(yeast) 224.13 104.97 0.138 474010 PTTG1IP Pituitary tumor-transforming1 interacting protein 472.39 85.43 0.138 474053 COL6A1 Collagen, typeVI, alpha 1 240.21 60.68 0.345 474083 B4GALT2 UDP-Gal:betaGlcNAc beta1,4-galactosyltransferase, polypeptide 2 118.57 65.47 0.345 474213 UFD1LUbiquitin fusion degradation 1 like (yeast) 117.12 72.56 0.276 474584AKR1A1 Aldo-keto reductase family 1, member A1 (aldehyde reductase)216.03 70.29 0.138 474643 C22orf28 Chromosome 22 open reading frame 28331.66 109.80 0.138 474751 MYH9 Myosin, heavy polypeptide 9, non-muscle426.57 109.52 0.069 474833 CSNK1E Casein kinase 1, epsilon 193.49 86.780.138 474914 RUTBC3 RUN and TBC1 domain containing 3 190.23 157.68 0.345474938 SLC25A17 Solute carrier family 25 (mitochondrial carrier;peroxisomal 113.70 81.93 0.345 membrane protein, 34 kDa), member 17474949 RBX1 Ring-box 1 145.55 82.29 0.241 474982 ACO2 Aconitase 2,mitochondrial 307.04 91.01 0.034 475125 ATXN10 Ataxin 10 198.54 95.440.172 475319 LRRFIP2 Leucine rich repeat (in FLII) interacting protein 2104.35 72.12 0.310 475382 MTMR14 Myotubularin related protein 14 149.4783.39 0.172 475392 TMEM111 Transmembrane protein 111 136.12 88.37 0.379475663 RAB5A RAB5A, member RAS oncogene family 119.70 91.27 0.241 475733TOP2B Topoisomerase (DNA) II beta 180 kDa 180.06 113.03 0.172 475812STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog108.24 76.02 0.310 B (S. cerevisiae) 476018 CTNNB1 Catenin(cadherin-associated protein), beta 1, 88 kDa 138.21 58.20 0.310 476033TXNDC12 Thioredoxin domain containing 12 (endoplasmic reticulum) 146.5770.89 0.172 476179 SMARCC1 SWI/SNF related, matrix associated, actindependent regulator of 171.16 127.75 0.138 chromatin, subfamily c,member 1 476221 IHPK2 Inositol hexaphosphate kinase 2 145.26 55.31 0.241476231 IMPDH2 IMP (inosine monophosphate) dehydrogenase 2 1006.91 110.380.034 476308 ALAS1 Aminolevulinate, delta-, synthase 1 132.82 82.500.345 476365 SCP2 Sterol carrier protein 2 690.56 180.11 0.276 476448FLNB Filamin B, beta (actin binding protein 278) 189.01 103.49 0.310476706 MRPL37 Mitochondrial ribosomal protein L37 249.66 66.27 0.172476930 CHMP2B Chromatin modifying protein 2B 143.22 100.41 0.310 477157DULLARD Dullard homolog (Xenopus laevis) 158.37 96.36 0.103 477789ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 167.45 84.600.138 477892 GYG1 Glycogenin 1 151.92 63.62 0.345 478000 MBNL1Muscleblind-like (Drosophila) 304.13 90.08 0.241 478044 PA2G4Proliferation-associated 2G4, 38 kDa 460.10 87.56 0.103 478553 EIF4A2Eukaryotic translation initiation factor 4A, isoform 2 403.21 91.850.069 479208 FBXL5 F-box and leucine-rich repeat protein 5 140.68 84.670.276 479264 LAP3 Leucine aminopeptidase 3 140.16 84.68 0.241 479634SLC30A9 Solute carrier family 30 (zinc transporter), member 9 123.9063.55 0.379 479693 SFRS11 Splicing factor, arginine/serine-rich 11189.39 69.99 0.172 479728 GAPDH Glyceraldehyde-3-phosphate dehydrogenase7330.72 80.18 0.000 479747 BCAR1 Breast cancer anti-estrogen resistance1 183.08 85.45 0.310 479814 POLR2B Polymerase (RNA) II (DNA directed)polypeptide B, 140 kDa 170.30 62.57 0.310 480073 HNRPD Heterogeneousnuclear ribonucleoprotein D (AU-rich element RN/ 229.02 68.01 0.103binding protein 1, 37 kDa) 480311 PDLIM5 PDZ and LIM domain 5 273.24235.65 0.241 480465 SCYE1 Small inducible cytokine subfamily E, member 1(endothelial 107.39 55.27 0.276 monocyte-activating) 480653 ANXA5Annexin A5 303.60 104.16 0.069 481571 UQCRH Similar toUbiquinol-cytochrome C reductase complex 11 kDa 229.54 102.84 0.138protein, mitochondrial precursor (Mitochondrial hinge protein)(Cytochrome C1, nonheme 11 kDa protein) (Complex III subunit VIII)481720 MYO10 Myosin X 140.50 130.53 0.310 481898 CCBL2 Cysteineconjugate-beta lyase 2 134.41 54.32 0.310 482144 RPL26 Similar to 60Sribosomal protein L26 447.43 95.30 0.034 482363 SLC30A5 Solute carrierfamily 30 (zinc transporter), member 5 78.30 56.98 0.379 482526 TINP1TGF beta-inducible nuclear protein 1 121.52 61.06 0.241 482868 KIAA0372KIAA0372 126.07 60.99 0.241 483036 PJA2 Praja 2, RING-H2 motifcontaining 158.62 65.91 0.276 483067 C5orf13 Chromosome 5 open readingframe 13 318.12 190.12 0.379 483305 HINT1 Histidine triad nucleotidebinding protein 1 236.40 118.42 0.207 483408 PPP2CA Protein phosphatase2 (formerly 2A), catalytic subunit, alpha 230.50 94.12 0.138 isoform483454 CNN3 Calponin 3, acidic 211.93 89.89 0.207 483486 JMJD1B Jumonjidomain containing 1B 107.12 52.95 0.310 484138 FBXW11 F-box and WD-40domain protein 11 117.64 68.50 0.379 484188 ATP6V0E1 ATPase, H+transporting, lysosomal 9 kDa, V0 subunit e1 159.10 68.32 0.138 484242UBXD8 UBX domain containing 8 125.98 75.93 0.207 484288 DDX41 DEAD(Asp-Glu-Ala-Asp) box polypeptide 41 214.13 74.98 0.138 484363 RNF130Ring finger protein 130 97.65 67.32 0.138 484551 CPM Carboxypeptidase M186.28 78.16 0.310 484813 DEK DEK oncogene (DNA binding) 260.77 83.220.172 485155 RPL35 Ribosomal protein L35 281.04 111.39 0.172 485195SORT1 Sortilin 1 150.82 80.52 0.345 485246 PSMA5 Proteasome (prosome,macropain) subunit, alpha type, 5 164.31 83.49 0.207 485262 MTCH1Mitochondrial carrier homolog 1 (C. elegans) 364.72 91.85 0.103 485365AHCYL1 S-adenosylhomocysteine hydrolase-like 1 182.57 61.85 0.207 485616DST Dystonin 144.43 74.83 0.276 486542 BCLAF1 BCL2-associatedtranscription factor 1 184.76 58.42 0.207 487027 VIL2 Villin 2 (ezrin)228.59 71.02 0.138 487054 TCP1 T-complex 1 209.76 78.62 0.138 487635BZW2 Basic leucine zipper and W2 domains 2 250.31 146.18 0.172 487774HNRPA2B1 Heterogeneous nuclear ribonucleoprotein A2/B1 218.53 87.550.103 488171 NUDCD3 NudC domain containing 3 607.73 183.50 0.034 488181OGDH Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 245.90110.90 0.207 488307 ECOP EGFR-coamplified and overexpressed protein151.47 75.46 0.345 488478 C7orf42 Chromosome 7 open reading frame 42151.66 70.90 0.207 488671 BAZ1B Bromodomain adjacent to zinc fingerdomain, 1B 114.54 65.20 0.207 489207 ASNS Asparagine synthetase 262.06124.38 0.172 489284 ARPC1B Actin related protein 2/3 complex, subunit1B, 41 kDa 555.08 109.32 0.103 489287 CPSF4 Cleavage and polyadenylationspecific factor 4, 30 kDa 171.76 69.89 0.172 489336 SYAP1 Synapseassociated protein 1, SAP47 homolog (Drosophila) 126.10 45.09 0.310489615 PBEF1 Pro-B-cell colony enhancing factor 1 211.67 111.85 0.276490203 CALD1 Caldesmon 1 242.44 103.25 0.207 490394 SSBP1Single-stranded DNA binding protein 1 444.28 309.52 0.241 490415 ZYXZyxin 259.67 90.01 0.138 490745 DNAJB6 DnaJ (Hsp40) homolog, subfamilyB, member 6 182.26 74.39 0.103 490795 FAM62B Family with sequencesimilarity 62 (C2 domain containing) 256.81 139.32 0.276 member B 490874MTX1 Metaxin 1 139.52 83.02 0.310 491336 ELP3 Elongation protein 3homolog (S. cerevisiae) 98.38 59.66 0.379 491359 LMNA Lamin A/C 797.11108.53 0.138 491440 PPP2CB Protein phosphatase 2 (formerly 2A),catalytic subunit, beta 146.90 77.42 0.276 isoform 491494 CCT3Chaperonin containing TCP1, subunit 3 (gamma) 1152.31 109.73 0.034491597 VDAC3 Voltage-dependent anion channel 3 189.10 60.03 0.207 491695UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 1324.03 205.58 0.276491745 TCEA1 Transcription elongation factor A (SII), 1 180.17 63.490.241 491988 TRAM1 Translocation associated membrane protein 1 151.7462.44 0.172 492236 WDR42A WD repeat domain 42A 135.63 62.96 0.310 492314LAPTM4B Lysosomal associated protein transmembrane 4 beta 315.85 98.920.138 492445 UBR5 Ubiquitin protein ligase E3 component n-recognin 5133.59 70.25 0.345 492599 EIF3S3 Eukaryotic translation initiationfactor 3, subunit 3 gamma, 40 kDa 457.44 91.86 0.069 492805 NMD3 NMD3homolog (S. cerevisiae) 154.69 68.25 0.276 493362 AK3L1 Adenylate kinase3 138.22 63.01 0.241 493750 WDR40A WD repeat domain 40A 158.95 64.130.345 494173 ANXA1 Annexin A1 663.71 206.40 0.138 494419 LAMP1Lysosomal-associated membrane protein 1 278.30 123.84 0.276 494457 NINJ1Ninjurin 1 146.99 120.17 0.379 494604 ANP32B Acidic (leucine-rich)nuclear phosphoprotein 32 family, member B 297.30 74.71 0.069 494614BAT2D1 BAT2 domain containing 1 103.03 72.44 0.310 494691 PFN1 Profilin1 582.68 96.95 0.069 494700 SLC44A1 Solute carrier family 44, member 1156.34 79.78 0.379 494985 FBXW2 F-box and WD-40 domain protein 2 97.4568.65 0.379 495039 NDUFA8 NADH dehydrogenase (ubiquinone) 1 alphasubcomplex, 8, 19 100.91 70.67 0.345 495349 KIAA0515 KIAA0515 213.7362.92 0.069 495471 PMPCA Peptidase (mitochondrial processing) alpha174.09 84.07 0.172 495605 CD99 CD99 antigen 171.31 62.16 0.138 495851APOO Apolipoprotein O 144.33 80.53 0.345 495960 ATP6AP2 ATPase, H+transporting, lysosomal accessory protein 2 177.66 91.25 0.276 496068PCTK1 PCTAIRE protein kinase 1 177.60 80.15 0.207 496098 OTUD5 OTUdomain containing 5 171.08 119.61 0.207 496271 ? Full-length cDNA cloneCS0DJ002YF04 of T cells (Jurkat cell line) 552.58 198.74 0.172 Cot10-normalized of Homo sapiens (human) 496487 ATF4 Activatingtranscription factor 4 (tax-responsive enhancer element 644.83 92.220.069 B67) 496646 IL13RA1 Interleukin 13 receptor, alpha 1 117.23 77.350.310 496684 LAMP2 Lysosomal-associated membrane protein 2 175.62 85.980.241 497183 IVNS1ABP Influenza virus NS1A binding protein 156.30 56.550.241 497599 WARS Tryptophanyl-tRNA synthetase 328.30 141.43 0.103497692 NSL1 NSL1, MIND kinetochore complex component, homolog (S.cerevisiae) 142.41 132.49 0.379 497893 ENAH Enabled homolog (Drosophila)133.62 90.22 0.276 498239 FH Fumarate hydratase 304.63 108.28 0.276498313 ADSS Adenylosuccinate synthase 138.41 96.89 0.276 498317 C1orf121Chromosome 1 open reading frame 121 139.90 108.25 0.379 498455 LARP5 Laribonucleoprotein domain family, member 5 142.32 72.97 0.241 498548RBM17 RNA binding motif protein 17 119.60 106.34 0.207 498727 DHCR2424-dehydrocholesterol reductase 380.21 178.18 0.207 499145 YME1L1YME1-like 1 (S. cerevisiae) 218.20 87.96 0.241 499158 GGA1 Golgiassociated, gamma adaptin ear containing, ARF binding 149.92 94.46 0.276protein 1 499594 TIMM23 Translocase of inner mitochondrial membrane 23homolog (yeast) 116.05 77.66 0.241 499833 REEP3 Receptor accessoryprotein 3 97.26 86.49 0.345 499891 HNRPH3 Heterogeneous nuclearribonucleoprotein H3 (2H9) 152.75 70.91 0.103 499925 VPS26A Vacuolarprotein sorting 26 homolog A (S. pombe) 129.39 63.83 0.172 499960 SAR1ASAR1 gene homolog A (S. cerevisiae) 122.18 69.10 0.172 500067 PPP3CBProtein phosphatase 3 (formerly 2B), catalytic subunit, beta 120.2766.72 0.241 isoform (calcineurin A beta) 500101 VCL Vinculin 197.78102.19 0.207 500375 ENTPD6 Ectonucleoside triphosphatediphosphohydrolase 6 (putative 163.42 84.78 0.276 function) 500409 GLUD1Glutamate dehydrogenase 1 161.37 95.54 0.138 500546 IDEInsulin-degrading enzyme 112.83 68.82 0.310 500674 TM9SF3 Transmembrane9 superfamily member 3 215.50 58.43 0.207 500775 ZNF207 Zinc fingerprotein 207 233.29 62.27 0.034 500842 MGEA5 Meningioma expressed antigen5 (hyaluronidase) 179.67 93.93 0.310 500874 CUEDC2 CUE domain containing2 129.96 52.06 0.310 501012 ADD3 Adducin 3 (gamma) 223.70 119.75 0.310501023 MXI1 MAX interactor 1 94.44 62.74 0.345 501203 TIAL1 TIA1cytotoxic granule-associated RNA binding protein-like 1 146.01 73.160.276 501293 BSG Basigin (OK blood group) 737.88 112.29 0.103 501309CIRBP Cold inducible RNA binding protein 265.44 117.90 0.034 501353PLEKHJ1 Pleckstrin homology domain containing, family J member 1 100.8756.61 0.379 501376 UROS Uroporphyrinogen III synthase (congenitalerythropoietic porphyria) 130.07 71.33 0.241 501420 NCLN Nicalin homolog(zebrafish) 177.01 86.48 0.241 501629 IER2 Immediate early response 2140.79 60.99 0.241 501684 NAP1L4 Nucleosome assembly protein 1-like 4166.93 111.13 0.138 501735 STIM1 Stromal interaction molecule 1 117.6271.87 0.276 501853 TMEM9B TMEM9 domain family, member B 110.79 91.410.379 501924 USP47 Ubiquitin specific peptidase 47 132.14 118.32 0.345501991 MLSTD2 Male sterility domain containing 2 96.74 62.95 0.379502302 CAT Catalase 158.19 107.96 0.345 502328 CD44 CD44 antigen (homingfunction and Indian blood group system) 366.11 100.63 0.172 502461 DGKZDiacylglycerol kinase, zeta 104 kDa 109.99 96.64 0.310 502528 NDUFS3NADH dehydrogenase (ubiquinone) Fe—S protein 3, 30 kDa 119.28 75.880.207 (NADH-coenzyme Q reductase) 502630 C11orf31 Chromosome 11 openreading frame 31 170.27 98.83 0.276 502659 RHOC Ras homolog gene family,member C 253.62 101.47 0.138 502705 PRPF19 PRP19/PSO4 pre-mRNAprocessing factor 19 homolog (S. cerevisiae) 198.31 100.04 0.276 502745FADS2 Fatty acid desaturase 2 266.18 116.45 0.276 502769 SLC3A2 Solutecarrier family 3 (activators of dibasic and neutral amino acid 276.2484.47 0.138 transport), member 2 502773 ADI1 Acireductone dioxygenase 1159.84 55.74 0.103 502823 PRDX5 Peroxiredoxin 5 183.65 76.11 0.241502829 SF1 Splicing factor 1 263.86 66.20 0.069 502836 ARL2ADP-ribosylation factor-like 2 134.06 114.72 0.310 502842 CAPN1 Calpain1, (mu/I) large subunit 287.11 101.89 0.207 502872 MAP3K11Mitogen-activated protein kinase kinase kinase 11 128.70 82.13 0.276502876 RHOB Ras homolog gene family, member B 165.00 92.57 0.310 503093ZFP36L2 Zinc finger protein 36, C3H type-like 2 150.79 67.83 0.207503222 RAB6A RAB6A, member RAS oncogene family 152.69 73.96 0.241 503251PPME1 Protein phosphatase methylesterase 1 123.71 52.56 0.207 503597HSPC148 Hypothetical protein HSPC148 107.89 76.02 0.276 503709 TMEM123Transmembrane protein 123 339.10 161.64 0.172 503716 DCUN1D5 DCN1,defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)167.32 87.13 0.138 503787 DARS Aspartyl-tRNA synthetase 147.34 55.170.138 504237 STT3A STT3, subunit of the oligosaccharyltransferasecomplex, homolog 117.19 108.95 0.345 A (S. cerevisiae) 504517 RPS27Tetraspanin 9 176.40 121.62 0.379 504613 PTMS Parathymosin 175.13 81.370.345 504620 PHB2 Prohibitin 2 506.51 79.86 0.069 504687 MYL9 Elongationfactor Tu family protein 343.66 100.94 0.379 504828 DDX47 DEAD(Asp-Glu-Ala-Asp) box polypeptide 47 130.63 59.08 0.379 504895 STRAPSerine/threonine kinase receptor associated protein 221.43 95.09 0.138505033 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 115.8283.04 0.310 505059 PSMD4 Proteasome (prosome, macropain) 26S subunit,non-ATPase, 4 259.00 62.63 0.103 505625 C12orf10 Chromosome 12 openreading frame 10 105.33 77.88 0.345 505652 COPZ1 Coatomer proteincomplex, subunit zeta 1 204.89 87.20 0.000 505676 CIP29 Cytokine inducedprotein 29 kDa 184.81 88.39 0.241 505705 MYL6 Myosin, light polypeptide6, alkali, smooth muscle and non-muscle 438.52 109.87 0.069 505806PBXIP1 Pre-B-cell leukemia transcription factor interacting protein 1115.75 83.63 0.310 505824 SAMM50 Sorting and assembly machinerycomponent 50 homolog (S. cerevisiae) 242.60 117.59 0.172 506215 RARSArginyl-tRNA synthetase 192.15 85.96 0.172 506325 NUDT4 Nudix(nucleoside diphosphate linked moiety X)-type motif 4 121.40 87.04 0.379pseudogene 2 506759 ATP2A2 ATPase, Ca++ transporting, cardiac muscle,slow twitch 2 375.19 241.76 0.241 506861 DDX54 DEAD (Asp-Glu-Ala-Asp)box polypeptide 54 199.70 104.77 0.241 507074 KIAA0152 KIAA0152 244.9089.86 0.069 507162 VPS37B Vacuolar protein sorting 37 homolog B (S.cerevisiae) 142.45 79.66 0.276 507584 POLR1D Polymerase (RNA) Ipolypeptide D, 16 kDa 121.94 73.07 0.241 507680 PFAAP5 Phosphonoformateimmuno-associated protein 5 143.30 68.40 0.345 507910 PGRMC2Progesterone receptor membrane component 2 131.09 75.85 0.207 507916TSC22D1 TSC22 domain family, member 1 344.52 102.84 0.172 508010 FNDC3AFibronectin type III domain containing 3A 264.21 157.30 0.241 508644FLJ10154 Hypothetical protein FLJ10154 183.99 75.88 0.310 509163 ERGIC1Endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 147.5471.85 0.103 509226 FKBP3 FK506 binding protein 3, 25 kDa 146.28 97.770.241 509264 KLHDC2 Kelch domain containing 2 117.21 72.23 0.207 509414KTN1 Kinectin 1 (kinesin receptor) 196.92 103.65 0.207 509622 RGL2 Ralguanine nucleotide dissociation stimulator-like 2 136.36 70.20 0.345509736 HSP90AB1 Heat shock protein 90 kDa alpha (cytosolic), class Bmember 1 2045.82 87.83 0.000 509791 ERH Enhancer of rudimentary homolog(Drosophila) 148.95 80.20 0.207 509909 NUMB Numb homolog (Drosophila)115.97 62.99 0.241 510087 ENSA Endosulfine alpha 196.15 70.81 0.034510328 DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 446.38 126.730.103 510402 CD46 CD46 molecule, complement regulatory protein 255.4387.89 0.276 511067 FAM82C Family with sequence similarity 82, member C193.94 125.16 0.345 511138 TMEM87A Transmembrane protein 87A 153.9071.25 0.241 511149 SNAP23 Synaptosomal-associated protein, 23 kDa 159.7670.15 0.276 511425 SRP9 Signal recognition particle 9 kDa 1439.84 206.140.069 511504 TCF12 Transcription factor 12 (HTF4, helix-loop-helixtranscription factors 175.22 83.75 0.276 4) 511862 Similar to 60S acidicribosomal protein P1 182.40 88.27 0.379 511952 CBX6 Chromobox homolog 6153.88 81.20 0.276 512005 ARPC3 Actin related protein 2/3 complex,subunit 3, 21 kDa 175.09 73.61 0.241 512465 SURF4 Surfeit 4 272.49 79.310.069 512525 RPS17 Ribosomal protein S17 1561.21 128.47 0.069 512607MIR16 Membrane interacting protein of RGS16 243.63 112.71 0.207 512640PRKCSH Protein kinase C substrate 80K-H 369.95 87.75 0.172 512661 ISY1ISY1 splicing factor homolog (S. cerevisiae) 247.17 110.21 0.241 512676RPS25 Ribosomal protein S25 200.49 132.68 0.241 512693 METT11D1Methyltransferase 11 domain containing 1 119.37 86.98 0.345 512756 THAP7THAP domain containing 7 139.40 88.58 0.345 512815 AP3D1 Adaptor-relatedprotein complex 3, delta 1 subunit 260.40 98.20 0.034 512857 CD151 CD151antigen 289.17 93.65 0.207 512867 CASC4 Cancer susceptibility candidate4 130.94 70.38 0.207 512908 ARPP-19 Cyclic AMP phosphoprotein, 19 kD226.51 76.75 0.207 513043 IMP3 IMP3, U3 small nucleolarribonucleoprotein, homolog (yeast) 135.64 58.16 0.310 513055 WDR61 WDrepeat domain 61 114.60 53.12 0.345 513057 RANBP5 RAN binding protein 5280.02 118.69 0.172 513058 TMED3 Transmembrane emp24 protein transportdomain containing 3 180.01 81.33 0.138 513071 MESDC1 Mesodermdevelopment candidate 1 153.38 113.49 0.276 513083 RPL9 Ribosomalprotein L9 1564.85 164.78 0.034 513141 IDH2 Isocitrate dehydrogenase 2(NADP+), mitochondrial 276.13 73.73 0.103 513145 NGRN Neugrin, neuriteoutgrowth associated 292.66 85.21 0.034 513153 FURIN Furin (paired basicamino acid cleaving enzyme) 171.95 95.68 0.379 513230 MRPL28Mitochondrial ribosomal protein L28 206.58 141.00 0.241 513242 RHOT2 Rashomolog gene family, member T2 146.56 66.79 0.345 513261 HN1LHematological and neurological expressed 1-like 169.07 73.84 0.138513266 NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22141.77 93.82 0.345 513470 NFATC2IP Nuclear factor of activated T-cells,cytoplasmic, calcineurin- 123.18 55.34 0.310 dependent 2 interactingprotein 513488 MVP Major vault protein 276.00 95.97 0.276 513490 ALDOAAldolase A, fructose-bisphosphate 1575.38 81.23 0.034 513520 BCKDKBranched chain ketoacid dehydrogenase kinase 181.01 99.21 0.276 513522FUS Fusion (involved in t(12; 16) in malignant liposarcoma) 402.21 88.890.034 513631 ARL2BP ADP-ribosylation factor-like 2 binding protein133.32 76.06 0.379 513856 DPH1 DPH1 homolog (S. cerevisiae) 153.80 77.150.172 513984 FLII Flightless 1 homolog (Drosophila) 218.66 80.64 0.103514012 MAP2K3 Mitogen-activated protein kinase kinase 3 206.91 198.730.379 514036 SDF2 Stromal cell-derived factor 2 139.48 83.16 0.379514038 FLOT2 Flotillin 2 205.94 75.37 0.241 514174 JUP Junctionplakoglobin 311.95 175.04 0.310 514196 RPL27 Ribosomal protein L27445.53 163.18 0.103 514211 TMEM101 Transmembrane protein 101 207.7066.43 0.345 514216 SLC25A39 Solute carrier family 25, member 39 372.0978.71 0.103 514220 GRN Granulin 569.94 118.75 0.103 514297 UBE2ZUbiquitin-conjugating enzyme E2Z (putative) 149.22 70.83 0.172 514303PHB Prohibitin 337.86 78.21 0.103 514435 SF3B3 Splicing factor 3b,subunit 3, 130 kDa 245.52 67.98 0.138 514489 WBP2 WW domain bindingprotein 2 367.18 97.07 0.138 514535 LGALS3BP Lectin,galactoside-binding, soluble, 3 binding protein 714.12 134.59 0.172514581 ACTG1 Actin, gamma 1 6790.08 96.54 0.000 514590 HGS Hepatocytegrowth factor-regulated tyrosine kinase substrate 234.48 89.80 0.241514819 AP2B1 Adaptor-related protein complex 2, bela 1 subunit 184.4753.67 0.207 514870 ATP5F1 ATP synthase, H+ transporting, mitochondrialF0 complex, subuni 441.56 130.47 0.034 b, isoform 1 514920 CALCOCOCalcium binding and coiled-coil domain 2 151.26 76.62 0.241 514934CAPZA1 Capping protein (actin filament) muscle Z-line, alpha 1 232.4984.07 0.276 515003 C19orf6 Chromosome 19 open reading frame 6 218.9296.61 0.172 515005 STK11 Serine/threonine kinase 11 (Peutz-Jegherssyndrome) 127.27 85.12 0.379 515018 GNA13 Guanine nucleotide bindingprotein (G protein), alpha 13 162.22 105.65 0.345 515053 AESAmino-terminal enhancer of split 314.90 95.73 0.138 515070 EEF2Eukaryotic translation elongation factor 2 403.41 101.00 0.034 515092CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit173.03 103.29 0.241 homolog (E. coli) 515155 C19orf43 Chromosome 19 openreading frame 43 161.94 77.42 0.138 515162 CALR Calreticulin 575.5888.03 0.034 515164 GADD45GIP1 Growth arrest and DNA-damage-inducible,gamma interacting 191.12 69.42 0.276 protein 1 515210 DNAJB1 DnaJ(Hsp40) homolog, subfamily B, member 1 233.68 80.33 0.207 515255 LSM4LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 266.66105.98 0.276 515266 UPF1 UPF1 regulator of nonsense transcripts homolog(yeast) 163.88 99.99 0.276 515271 SFRS14 Splicing factor,arginine/serine-rich 14 124.30 81.86 0.310 515329 RPL22 Ribosomalprotein L22 191.43 75.49 0.138 515371 CAPNS1 Calpain, small subunit 1404.46 95.10 0.069 515406 AKT2 V-akt murine thymoma viral oncogenehomolog 2 139.00 124.72 0.345 515417 EGLN2 Egl nine homolog 2 (C.elegans) 257.04 138.23 0.379 515432 DEDD2 Death effector domaincontaining 2 94.65 52.25 0.379 515472 SNRPD2 Small nuclearribonucleoprotein D2 polypeptide 16.5 kDa 292.31 154.43 0.207 515475SYMPK Symplekin 133.18 53.29 0.241 515487 CALM3 Calmodulin 3(phosphorylase kinase, delta) 439.26 95.22 0.069 515494 SLC1A5 Solutecarrier family 1 (neutral amino acid transporter), member 5 448.32106.79 0.138 515500 SAE1 SUMO-1 activating enzyme subunit 1 380.21 79.670.034 515515 KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum proteinretention 261.62 81.81 0.138 receptor 1 515517 RPL18 Ribosomal proteinL18 743.38 74.48 0.103 515524 NUCB1 Nucleobindin 1 350.34 117.21 0.103515540 PTOV1 Prostate tumor overexpressed gene 1 175.30 98.47 0.172515550 LOC284361 Hematopoietic signal peptide-containing 135.48 82.610.310 515598 PRPF31 PRP31 pre-mRNA processing factor 31 homolog (yeast)368.40 151.24 0.276 515607 PPP1R12C Protein phosphatase 1, regulatory(inhibitor) subunit 12C 165.22 97.14 0.379 515642 GPSN2 Glycoprotein,synaptic 2 171.37 74.21 0.345 515785 BLVRB Biliverdin reductase B(flavin reductase (NADPH)) 143.92 94.30 0.310 515846 RUVBL2 RuvB-like 2(E. coli) 354.78 98.40 0.138 515848 HADHB Hydroxyacyl-Coenzyme Adehydrogenase/3-ketoacyl-Coenzyme 213.42 90.90 0.103thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), betasubunit 515890 YPEL5 Yippee-like 5 (Drosophila) 181.92 82.16 0.276516075 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 183.2380.58 0.310 516077 FLJ14668 Hypothetical protein FLJ14668 112.96 75.820.276 516087 TEX261 Testis expressed sequence 261 146.81 110.15 0.241516111 DCTN1 Dynactin 1 (p150, glued homolog, Drosophila) 261.96 94.410.103 516114 WBP1 WW domain binding protein 1 114.03 56.61 0.310 516157MAT2A Methionine adenosyltransferase II, alpha 195.52 68.87 0.172 516450SMPD4 Sphingomyelin phosphodiesterase 4, neutral membrane (neutral248.30 97.54 0.172 sphingomyelinase-3) 516522 INTS3 Integrator complexsubunit 3 142.16 102.91 0.379 516539 HNRPA3 Heterogeneous nuclearribonucleoprotein A3 223.52 72.69 0.138 516587 UBE2Q1Ubiquitin-conjugating enzyme E2Q (putative) 1 131.58 55.37 0.345 516533NCKAP1 NCK-associated protein 1 198.42 62.97 0.241 516711 CHPFChondroitin polymerizing factor 213.73 142.81 0.379 516790 ARHGEF2Rho/rac guanine nucleotide exchange factor (GEF) 2 133.62 84.47 0.379516807 STK25 Serine/threonine kinase 25 (STE20 homolog, yeast) 455.41109.35 0.138 516826 TRIB3 Tribbles homolog 3 (Drosophila) 228.24 99.310.241 516855 CENPB Centromere protein B, 80 kDa 202.67 80.52 0.276517080 SLC35C2 Solute carrier family 35, member C2 163.93 94.82 0.207517106 CEBPB CCAAT/enhancer binding protein (C/EBP), beta 178.82 93.370.345 517134 C20orf43 Chromosome 20 open reading frame 43 247.39 69.920.069 517145 ENO1 Enolase 1, (alpha) 3401.32 102.15 0.000 517168 TAGLN2Transgelin 2 626.02 75.92 0.069 517216 PEA15 Phosphoprotein enriched inastrocytes 15 283.17 82.20 0.172 517232 PEX19 Peroxisomal biogenesisfactor 19 151.27 57.99 0.207 517240 IFNGR2 Interferon gamma receptor 2(interferon gamma transducer 1) 158.55 79.26 0.172 517262 SON SON DNAbinding protein 197.08 79.92 0.138 517293 F11R F11 receptor 215.86109.54 0.276 517338 ATP6V1E1 ATPase, H+ transporting, lysosomal 31 kDa,V1 subunit E isoform 1 197.20 81.17 0.069 517342 DEDD Death effectordomain containing 136.31 62.93 0.276 517356 COL18A1 Collagen, typeXVIII, alpha 1 388.40 175.92 0.345 517357 DGCR2 DiGeorge syndromecritical region gene 2 214.17 92.03 0.241 517421 PCQAP PC2 (positivecofactor 2, multiprotein complex) glutamine/Q-rich- 205.74 178.98 0.241associated protein 517438 ASCC2 Activating signal cointegrator 1 complexsubunit 2 138.59 89.52 0.138 517517 EP300 E1A binding protein p300124.61 92.25 0.379 517543 PES1 Pescadillo homolog 1, containing BRCTdomain (zebrafish) 242.64 124.33 0.276 517582 MCM5 MCM5 minichromosomemaintenance deficient 5, cell division 424.00 105.24 0.172 cycle 46 (S.cerevisiae) 517622 UNC84B Unc-84 homolog B (C. elegans) 131.34 80.160.310 517641 L3MBTL2 L(3)mbt-like 2 (Drosophila) 116.46 67.43 0.345517666 CYB5R3 Cytochrome b5 reductase 3 314.58 161.98 0.138 517731 TRABDTraB domain containing 180.88 102.41 0.276 517768 BRP44 Brain protein 44127.10 104.51 0.345 517792 C3orf10 Chromosome 3 open reading frame 10175.04 80.24 0.069 517817 TMEM43 Transmembrane protein 43 136.66 75.360.310 517821 CDNA clone IMAGE: 5278517 120.53 66.29 0.310 517888 CRTAPCartilage associated protein 208.15 77.38 0.207 517948 DHX30 DEAH(Asp-Glu-Ala-His) box polypeptide 30 209.13 121.04 0.207 517949 MAP4Microtubule-associated protein 4 306.69 79.18 0.103 517969 APEHN-acylaminoacyl-peptide hydrolase 330.37 60.97 0.207 517981 TUSC2 Tumorsuppressor candidate 2 129.92 69.61 0.310 518060 ARL6IP5ADP-ribosylation-like factor 6 interacting protein 5 303.59 116.09 0.207518123 TFG TRK-fused gene 189.81 59.70 0.138 518236 SEC61A1 Sec61 alpha1 subunit (S. cerevisiae) 272.42 82.37 0.138 518244 RPN1 Ribophorin I232.54 86.03 0.172 518249 CNBP CCHC-type zinc finger, nucleic acidbinding protein 307.66 69.72 0.034 518250 COPG Coatomer protein complex,subunit gamma 205.51 104.21 0.276 518265 CDV3 CDV3 homolog (mouse)192.56 91.81 0.138 518326 SERP1 Stress-associated endoplasmic reticulumprotein 1 233.71 64.27 0.069 518346 SSR3 Signal sequence receptor, gamma(translocon-associated protein 133.69 62.65 0.241 gamma) 518374 QSOX1Quiescin Q6 sulfhydryl oxidase 1 151.71 84.80 0.310 518424 NDUFB5 NADHdehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16 kDa 625.19 180.450.276 518460 AP2M1 Adaptor-related protein complex 2, mu 1 subunit584.10 76.35 0.069 518464 PSMD2 Proteasome (prosome, macropain) 26Ssubunit, non-ATPase, 2 538.23 93.02 0.103 518525 GLUL Glutamate-ammonialigase (glutamine synthetase) 326.37 86.68 0.138 518551 RPL31 Ribosomalprotein L31 883.50 204.46 0.103 518608 MRFAP1L1 Morf4 family associatedprotein 1-like 1 107.24 53.27 0.172 518609 ARPC5 Actin related protein2/3 complex, subunit 5, 16 kDa 226.65 65.59 0.172 518750 OCIAD1 OCIAdomain containing 1 121.73 78.62 0.172 518805 HMGA1 High mobility groupAT-hook 1 1583.57 131.69 0.172 518827 CCNI Cyclin I 495.99 157.57 0.034519276 MAPKAPK2 Mitogen-activated protein kinase-activated proteinkinase 2 172.89 87.16 0.172 519304 PELO Pelota homolog (Drosophila)204.10 151.63 0.310 519346 ERBB2IP Erbb2 interacting protein 171.0583.90 0.241 519347 SFRS12 Splicing factor, arginine/serine-rich 12 99.9849.97 0.310 519520 RPS25 Ribosomal protein S25 717.45 181.09 0.034519523 SERPINB6 Serpin peptidase inhibitor, clade B (ovalbumin), member6 180.64 74.06 0.172 519557 TMEM14C Transmembrane protein 14C 139.6270.39 0.276 519718 TTC1 Tetratricopeptide repeat domain 1 119.41 63.740.276 519756 STK10 Serine/threonine kinase 10 131.85 89.36 0.379 519818MGAT1 Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N- 179.60 85.97 0.138acetylglucosaminyltransferase 519909 MARCKS Myristoylated alanine-richprotein kinase C substrate 360.12 219.46 0.310 519930 C6orf62 Chromosome6 open reading frame 62 131.39 63.83 0.138 520026 VARS2 Valyl-tRNAsynthetase 317.40 77.78 0.241 520028 HSPA1A Heat shock 70 kDa protein 1A267.63 174.20 0.241 520037 NEU1 Sialidase 1 (lysosomal sialidase) 229.35119.62 0.310 520070 CUTA CUtA divalent cation tolerance homolog (E.coli) 154.48 68.26 0.207 520140 SRF Serum response factor (c-fos serumresponse element-binding 130.75 59.73 0.379 transcription factor) 520189ELOVL5 ELOVL family member 5, elongation of long chain fatty acids137.81 70.07 0.276 (FEN1/Elo2, SUR4/Elo3-like, yeast) 520205 EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1 238.20 66.390.138 520210 KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum proteinretention 225.97 94.83 0.138 receptor 2 520287 C6orf111 Chromosome 6open reading frame 111 170.77 69.67 0.207 520313 CD164 CD164 antigen,sialomucin 387.43 78.65 0.172 520383 STX7 Syntaxin 7 200.61 198.70 0.379520421 PERP PERP, TP53 apoptosis effector 278.10 105.31 0.379 520459GTF2I General transcription factor II, i 179.36 111.40 0.345 520623C7orf27 Chromosome 7 open reading frame 27 107.46 71.73 0.345 520640ACTB Actin, beta 4381.34 95.98 0.034 520740 SCRN1 Secernin 1 162.4176.80 0.276 520794 YKT6 SNARE protein Ykt6 322.61 99.65 0.276 520898CTSB Cathepsin B 555.78 100.98 0.034 520943 EIF4H Eukaryotic translationinitiation factor 4H 520.03 71.02 0.069 520967 MDH2 Malate dehydrogenase2, NAD (mitochondrial) 368.83 66.26 0.069 520973 HSPB1 Heat shock 27 kDaprotein 1 608.95 126.99 0.138 520974 YWHAG Tyrosine3-monooxygenase/tryptophan 5-monooxygenase 171.99 87.92 0.310 activationprotein, gamma polypeptide 521064 ZNF655 Zinc finger protein 655 100.3168.90 0.379 521151 ZNF672 Zinc finger protein 672 185.36 113.36 0.310521289 REPIN1 Replication initiator 1 220.03 101.31 0.172 521487 TMEM66Transmembrane protein 66 276.62 74.21 0.138 521640 RAD23B RAD23 homologB (S. cerevisiae) 334.78 294.31 0.241 521809 RP13- Cofactor of BRCA1180.78 84.61 0.172 122B23.3 521903 LY6E Lymphocyte antigen 6 complex,locus E 425.61 138.70 0.172 521924 SIAHBP1 Fuse-bindingprotein-interacting repressor 381.93 82.10 0.103 521969 NDUFB11 NADHdehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa 144.58 114.750.379 521973 WDR13 WD repeat domain 13 177.47 106.14 0.172 522074TSC22D3 TSC22 domain family, member 3 194.81 93.94 0.207 522110 CREB3CAMP responsive element binding protein 3 153.05 94.31 0.241 522114 CLTAClathrin, light polypeptide (Lca) 317.85 88.44 0.103 522310 NANSN-acetylneuraminic acid synthase (sialic acid synthase) 114.60 62.520.310 522373 GSN Gelsolin (amyloidosis, Finnish type) 434.41 204.850.138 522394 HSPA5 Heat shock 70 kDa protein 5 (glucose-regulatedprotein, 78 kDa) 367.53 102.24 0.172 522463 EEF1A1 Eukaryotictranslation elongation factor 1 alpha 1 9324.87 148.86 0.000 522507FBXW5 F-box and WD-40 domain protein 5 199.15 90.48 0.276 522584 TMSB4XThymosin, beta 4, X-linked 1362.45 161.68 0.172 522590 EIF1AX Eukaryotictranslation initiation factor 1A, X-linked 136.35 67.99 0.207 522632TIMP1 TIMP metallopeptidase inhibitor 1 386.91 180.87 0.241 522665MAGED2 Melanoma antigen family D, 2 430.71 110.49 0.138 522675 LAS1LLAS1-like (S. cerevisiae) 201.59 69.13 0.241 522752 PSMD10 Proteasome(prosome, macropain) 26S subunit, non-ATPase, 10 122.91 60.90 0.276522817 BCAP31 B-cell receptor-associated protein 31 290.93 84.50 0.172522819 IRAK1 Interleukin-1 receptor-associated kinase 1 382.94 97.800.138 522823 EMD Emerin (Emery-Dreifuss muscular dystrophy) 171.35 87.580.379 522932 NCOA4 Nuclear receptor coactivator 4 209.19 70.05 0.138522995 EIF4EBP2 Eukaryotic translation initiation factor 4E bindingprotein 2 176.81 73.83 0.103 523004 PSAP Prosaposin (variant Gaucherdisease and variant metachromatic 1098.27 123.65 0.034 leukodystrophy)523012 DDIT4 DNA-damage-inducible transcript 4 415.15 125.10 0.276523054 TMEM50A Transmembrane protein 50A 139.64 109.41 0.276 523131TRAPPC3 Trafficking protein particle complex 3 139.68 66.61 0.310 523145DDOST Dolichyl-diphosphooligosaccharide-protein glycosyltransferase338.02 90.17 0.103 523215 NDUFB8 NADH dehydrogenase (ubiquinone) 1 betasubcomplex, 8, 19 kDa 199.51 106.37 0.172 523238 NOLC1 Nucleolar andcoiled-body phosphoprotein 1 176.02 83.34 0.138 523262 TMEM59Transmembrane protein 59 262.49 95.63 0.069 523299 EIF3S10 Eukaryotictranslation initiation factor 3, subunit 10 theta, 150/170 kDa 180.2576.56 0.172 523302 PRDX3 Peroxiredoxin 3 948.84 182.31 0.138 523560HSP90AA2 Heat shock protein 90 kDa alpha (cytosolic), class A member 2971.87 81.16 0.000 523680 SSRP1 Structure specific recognition protein 1259.94 67.23 0.138 523789 TncRNA Trophoblast-derived noncoding RNA290.76 109.38 0.310 523829 POLD4 Polymerase (DNA-directed), delta 4192.79 92.64 0.310 523836 GSTP1 Glutathione S-transferase pi 363.8379.45 0.103 523852 CCND1 Cyclin D1 257.94 79.21 0.310 523875 INPPL1Inositol polyphosphate phosphatase-like 1 198.48 82.78 0.310 524009AASDHPPT Aminoadipate-semialdehyde dehydrogenase-phosphopantetheiny139.83 74.10 0.345 transferase 524081 DPAGT1 Dolichyl-phosphate(UDP-N-acetylglucosamine) N- 125.85 78.99 0.345acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase 524084RNF26 Ring finger protein 26 170.50 95.60 0.310 524161 RSU1 Rassuppressor protein 1 173.91 80.13 0.276 524171 RAD52 RAD52 homolog (S.cerevisiae) 128.36 73.88 0.345 524183 FKBP4 FK506 binding protein 4, 59kDa 345.04 165.12 0.138 524195 ARHGAP2 Rho GTPase activating protein 21118.87 87.10 0.379 524214 MLF2 Myeloid leukemia factor 2 271.91 68.750.138 524219 TPI1 Triosephosphate isomerase 1 1085.58 88.77 0.069 524271PHC2 Polyhomeotic-like 2 (Drosophila) 333.79 105.07 0.138 524367 CBARA1Calcium binding atopy-related autoantigen 1 133.75 65.29 0.207 524395TUBA1A Tubulin, alpha 1a 423.08 127.26 0.241 524464 ATP5G2 ATP synthase,H+ transporting, mitochondrial F0 complex, subunit 300.01 124.98 0.172 c(subunit 9), isoform 2 524502 RNF41 Ring finger protein 41 110.38 68.590.241 524530 CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II,polypeptide A 286.91 136.97 0.103 small phosphatase 2 524590 RAB21RAB21, member RAS oncogene family 112.13 48.40 0.379 524599 NAP1L1 60Sribosomal protein L6 (RPL6A) 559.97 99.14 0.034 524690 PPIEPeptidylprolyl isomerase E (cyclophilin E) 224.33 109.34 0.207 524788RAB35 RAB35, member RAS oncogene family 97.18 65.96 0.379 524809 CLIP1CAP-GLY domain containing linker protein 1 121.91 90.76 0.345 524899SAP18 Sin3-associated polypeptide, 18 kDa 129.03 72.41 0.172 524920ZFP91 Zinc finger protein 91 homolog (mouse) 128.10 83.51 0.207 524969UFM1 Ubiquitin-fold modifier 1 172.41 84.47 0.310 525134 POMGNT1 ProteinO-linked mannose beta1,2-N- 161.82 102.74 0.345acetylglucosaminyltransferase 525163 ANKRD10 Ankyrin repeat domain 10156.22 79.59 0.207 525232 LRP10 Low density lipoprotein receptor-relatedprotein 10 201.98 129.16 0.138 525238 C14orf119 Chromosome 14 openreading frame 119 141.96 104.26 0.276 525330 ARF6 ADP-ribosylationfactor 6 191.66 134.63 0.103 525391 C1orf123 Chromosome 1 open readingframe 123 98.24 87.20 0.310 525527 RER1 RER1 retention in endoplasmicreticulum 1 homolog (S. cerevisiae) 137.56 72.32 0.310 525626 PACS2Phosphofurin acidic cluster sorting protein 2 126.74 98.42 0.345 525899C6orf49 Chromosome 6 open reading frame 49 144.67 83.87 0.172 526464 PMLPromyelocytic leukemia 129.51 84.95 0.345 526521 MDH1 Malatedehydrogenase 1, NAD (soluble) 414.98 150.61 0.103 527105 HNRPDLHeterogeneous nuclear ribonucleoprotein D-like 215.39 95.16 0.207 527193RPS23 Ribosomal protein S23 178.23 128.51 0.207 527348 AKAP9 A kinase(PRKA) anchor protein (Yotiao) 9 103.64 60.76 0.310 527412 ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1 216.47 95.28 0.241527861 OS9 Amplified in osteosarcoma 317.55 151.86 0.138 527862 PKD1Hypothetical protein LOC339047 142.25 87.72 0.345 527980 DUT DUTPpyrophosphatase 150.77 79.02 0.207 528050 HARS Histidyl-tRNA synthetase171.62 84.32 0.138 528222 NDUFS4 NADH dehydrogenase (ubiquinone) Fe—Sprotein 4, 18 kDa 112.10 94.04 0.276 (NADH-coenzyme Q reductase) 528300PITRM1 Pitrilysin metallopeptidase 1 122.00 61.07 0.276 528305 DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 298.20 91.95 0.138 528572SORBS3 Sorbin and SH3 domain containing 3 187.70 104.57 0.345 528668RPL6 Ribosomal protein L6 1037.68 85.03 0.034 528780 GSPT1 G1 to S phasetransition 1 170.88 56.71 0.138 528803 UQCRC2 Ubiquinol-cytochrome creductase core protein II 272.39 84.82 0.103 529059 EIF3S4 Eukaryotictranslation initiation factor 3, subunit 4 delta, 44 kDa 311.33 92.440.172 529132 SEPW1 Selenoprotein W 1 231.08 110.89 0.276 529244 NCK2 NCKadaptor protein 2 236.70 169.13 0.345 529280 ANAPC7 Anaphase promotingcomplex subunit 7 94.04 52.31 0.379 529303 ARPC2 Actin related protein2/3 complex, subunit 2, 34 kDa 329.77 127.35 0.034 529369 AFAP1 Actinfilament associated protein 1 101.03 56.96 0.379 529400 IFNAR1Interferon (alpha, beta and omega) receptor 1 108.71 56.53 0.310 529420UBE2G2 Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) 160.64100.65 0.103 529591 TLOC1 Translocation protein 1 141.82 65.80 0.172529618 TFRC Transferrin receptor (p90, CD71) 212.76 85.52 0.241 529631RPL35A Ribosomal protein L35a 453.58 173.13 0.103 529782 VCPValosin-containing protein 532.58 85.03 0.034 529798 BTF3 Basictranscription factor 3 400.11 94.96 0.069 529862 CSNK1A1 Casein kinase1, alpha 1 210.72 69.09 0.103 529890 CANX Calnexin 399.31 129.28 0.069529892 SQSTM1 Sequestosome 1 789.12 108.86 0.034 529957 SEC63 SEC63-like(S. cerevisiae) 120.12 80.80 0.276 530096 EIF3S2 Eukaryotic translationinitiation factor 3, subunit 2 beta, 36 kDa 451.94 86.61 0.034 530118LUC7L2 LUC7-like 2 (S. cerevisiae) 132.76 59.55 0.172 530291 ANXA11Annexin A11 279.25 86.71 0.069 530314 SSNA1 Sjogren's syndrome nuclearautoantigen 1 122.20 58.54 0.379 530331 PDHA1 Pyruvate dehydrogenase(lipoamide) alpha 1 179.99 79.37 0.207 530381 PIM3 Pim-3 oncogene 114.6172.86 0.345 530412 SERBP1 SERPINE1 mRNA binding protein 1 289.56 66.470.069 530436 STXBP3 Syntaxin binding protein 3 113.84 77.40 0.276 530479PMF1 Polyamine-modulated factor 1 128.35 73.53 0.241 530687 RNH1Ribonuclease/angiogenin inhibitor 1 342.47 102.27 0.172 530734 MRPL16Mitochondrial ribosomal protein L16 106.22 67.89 0.345 530753 C11orf59Chromosome 11 open reading frame 59 153.75 63.46 0.276 530823 COPS7ACOP9 constitutive photomorphogenic homolog subunit 7A 202.70 132.830.138 (Arabidopsis) 530862 PRKAG1 Protein kinase, AMP-activated, gamma 1non-catalytic subunit 136.75 73.16 0.241 531081 LGALS3 Lectin,galactoside-binding, soluble, 3 (galectin 3) 318.01 134.08 0.241 531089PSMA3 Proteasome (prosome, macropain) subunit, alpha type, 3 218.4093.16 0.276 531176 SARS Seryl-tRNA synthetase 297.55 88.08 0.138 531330CBWD1 COBW domain containing 2 123.09 79.22 0.310 531614 BTBD14B BTB(POZ) domain containing 14B 123.09 63.39 0.310 531752 RANBP3 RAN bindingprotein 3 122.49 64.65 0.310 531856 GAS5 Growth arrest-specific 5 227.80134.55 0.241 531876 DYNLRB1 Dynein, light chain, roadblock-type 1 167.51104.22 0.241 531879 RAD1 RAD1 homolog (S. pombe) 115.15 74.02 0.379532359 RPL5 Ribosomal protein L5 747.39 72.96 0.000 532399 ZC3H11A Zincfinger CCCH-type containing 11A 139.50 74.48 0.241 532755 C16orf80Chromosome 16 open reading frame 80 95.17 63.38 0.207 532790 NMT1N-myristoyltransferase 1 165.97 105.96 0.172 532793 KPNB1 Karyopherin(importin) beta 1 568.94 129.62 0.000 532803 HN1 Hematological andneurological expressed 1 225.82 90.89 0.103 532826 MCL1 Myeloid cellleukemia sequence 1 (BCL2-related) 252.48 83.80 0.207 532853 NDUFB7 NADHdehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18 kDa 145.80 84.030.345 533030 TRIOBP TRIO and F-actin binding protein 339.95 148.19 0.207533059 TUBB Tubulin, beta polypeptide 2476.41 87.07 0.000 533122 SFRS10Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, 182.5260.97 0.034 Drosophila) 533136 LRPAP1 Low density lipoproteinreceptor-related protein associated protein 1 234.76 108.38 0.207 533192TOMM20 Translocase of outer mitochondrial membrane 20 homolog (yeast)208.87 77.43 0.138 533222 DIMT1L DIM1 dimethyladenosine transferase1-like (S. cerevisiae) 129.17 69.14 0.379 533245 DDX46 DEAD(Asp-Glu-Ala-Asp) box polypeptide 46 118.53 50.97 0.345 533282 NONONon-POU domain containing, octamer-binding 842.92 104.94 0.034 533308PPP2R5D Protein phosphatase 2, regulatory subunit B (B56), delta isoform223.23 100.62 0.138 533317 VIM Vimentin 1800.81 137.19 0.069 533437TCEB1 Transcription elongation factor B (SIII), polypeptide 1 (15 kDa,121.08 94.03 0.276 elongin C) 533440 WWP1 WW domain containing E3ubiquitin protein ligase 1 146.51 87.93 0.345 533474 PPP1R8 Proteinphosphatase 1, regulatory (inhibitor) subunit 8 95.08 118.26 0.379533479 LYPLA2 Lysophospholipase II 223.79 59.26 0.276 533526 ATRX Alphathalassemia/mental retardation syndrome X-linked (RAD54 149.83 61.380.276 homolog, S. cerevisiae) 533624 H3F3A H3 histone, family 3A 322.4481.23 0.103 533712 RBM4 RNA binding motif protein 4 169.22 66.18 0.138533732 SRP14 Signal recognition particle 14 kDa (homologous Alu RNAbinding 223.87 85.87 0.172 protein) 533771 STUB1 STIP1 homology andU-box containing protein 1 238.45 84.03 0.241 533782 KRT8 Keratin 81307.25 94.61 0.379 533977 TXNIP Thioredoxin interacting protein 429.7392.27 0.034 533985 EXOC7 Exocyst complex component 7 168.92 93.23 0.276533986 ZMYM6 Zinc finger, MYM-type 6 99.16 62.99 0.310 534125 HLA-CMajor histocompatibility complex, class I, C 610.10 155.80 0.034 534168NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5 kDa261.51 202.07 0.310 534212 SEC22B SEC22 vesicle trafficking proteinhomolog B (S. cerevisiae) 107.96 68.79 0.379 534255 B2MBeta-2-microglobulin 1303.98 172.16 0.000 534307 CCND3 Cyclin D3 471.76356.89 0.207 534314 EIF5A Eukaryotic translation initiation factor 5A438.38 88.29 0.207 534326 ITGB4BP Integrin beta 4 binding protein 360.0678.91 0.103 534338 PPP4C Protein phosphatase 4 (formerly X), catalyticsubunit 191.52 75.42 0.138 534346 RPS7 Ribosomal protein S7 572.81120.27 0.000 534350 SMARCB1 SWI/SNF related, matrix associated, actindependent regulator of 210.96 162.57 0.172 chromatin, subfamily b,member 1 534453 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alphasubcomplex, 13 194.91 119.87 0.138 534456 ANAPC11 APC11 anaphasepromoting complex subunit 11 homolog (yeast) 164.01 99.17 0.172 534457C14orf166 Chromosome 14 open reading frame 166 171.37 66.04 0.138 534473TOMM22 Translocase of outer mitochondrial membrane 22 homolog (yeast)144.72 100.10 0.207 534483 PHF23 PHD finger protein 23 123.34 63.040.276 536275 PACS1 Phosphofurin acidic cluster sorting protein 1 217.8286.00 0.345 541269 NDUFB9 NADH dehydrogenase (ubiquinone) 1 betasubcomplex, 9, 22 kDa 269.72 132.31 0.172 546248 CTSD Cathepsin D(lysosomal aspartyl peptidase) 660.73 119.52 0.103 546250 DYNC1I2Dynein, cytoplasmic 1, intermediate chain 2 154.54 71.13 0.172 546253FDFT1 Farnesyl-diphosphate farnesyltransferase 1 249.53 81.90 0.034546261 HNRPA1 Heterogeneous nuclear ribonucleoprotein A1 649.46 94.550.000 546269 RPL10A Ribosomal protein L10a 706.14 175.46 0.103 546271PCBP2 Poly(rC) binding protein 2 293.34 87.15 0.103 546286 RPS3Ribosomal protein S3 2290.87 95.60 0.000 546289 RPS12 Ribosomal proteinS12 527.74 281.85 0.103 546290 RPS18 Ribosomal protein S18 939.29 233.810.069 546291 RPS27 Ribosomal protein S27 (metallopanstimulin 1) 725.59382.56 0.172 546339 C11orf58 Chromosome 11 open reading frame 58 580.69190.75 0.138 546356 RPL13A Ribosomal protein L13a 1352.43 84.32 0.000546394 CCDC72 Coiled-coil domain containing 72 244.28 200.01 0.241547759 SSBP3 Single stranded DNA binding protein 3 124.35 57.76 0.310549178 C9orf86 Chromosome 9 open reading frame 86 219.13 114.79 0.138552590 HTF9C HpaII tiny fragments locus 9C 107.24 77.34 0.276 553496PGM3 Phosphoglucomutase 3 103.08 61.39 0.379 553512 MBOAT5 Membranebound O-acyltransferase domain containing 5 124.81 75.10 0.310 554767NUP88 Nucleoporin 88 kDa 120.01 86.75 0.345 554776 SREBF1 Sterolregulatory element binding transcription factor 1 171.91 88.02 0.276554894 WDR54 WD repeat domain 54 114.62 72.99 0.345 554896 C7orf50Chromosome 7 open reading frame 50 193.18 101.69 0.207 555194 FAM36AFamily with sequence similarity 36, member A 120.40 52.67 0.276 555866C1QBP Complement component 1, q subcomponent binding protein 312.3377.95 0.138 555873 HNRPAB Heterogeneous nuclear ribonucleoprotein A/B316.21 89.74 0.034 555875 IDH3A Isocitrate dehydrogenase 3 (NAD+) alpha143.01 87.51 0.345 555889 PSMC2 Proteasome (prosome, macropain) 26Ssubunit, ATPase, 2 219.37 69.24 0.172 555890 RBBP4 Retinoblastomabinding protein 4 204.72 80.47 0.172 555911 RBM8A RNA binding motifprotein 8A 125.26 75.03 0.172 555969 RIC8A Resistance to inhibitors ofcholinesterase 8 homolog A (C. elegans) 261.31 93.56 0.172 555971 TMBIM1Transmembrane BAX inhibitor motif containing 219.28 114.17 0.207 555973MRPS25 Mitochondrial ribosomal protein S25 152.15 62.00 0.207 555994LONP2 Ion peptidase 2, peroxisomal 135.95 87.69 0.379 556267 FBXL10F-box and leucine-rich repeat protein 10 81.84 65.86 0.379 556461 NDUFV2NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa 146.86 108.590.207 556795 PAICS Phosphoribosylaminoimidazole carboxylase, 253.7689.34 0.138 phosphoribosylaminoimidazole succinocarboxamide synthetase557550 NPM1 Nucleophosmin (nucleolar phosphoprotein B23, numatrin)1675.95 168.64 0.000 558296 ACP1 Acid phosphatase 1, soluble 123.8158.79 0.172 558313 COX6A1 Cytochrome c oxidase subunit VIa polypeptide 1170.58 93.53 0.241 558322 EEF1B2 Eukaryotic translation elongationfactor 1 beta 2 450.71 94.79 0.034 558325 EIF5 Eukaryotic translationinititation factor 5 232.38 85.09 0.172 558328 FKBP5 FK506 bindingprotein 5 117.84 59.52 0.310 558330 FTL Ferritin, light polypeptide2521.41 158.72 0.069 558338 HSPE1 Heat shock 10 kDa protein 1(chaperonin 10) 270.37 133.18 0.207 558345 IK IK cytokine,down-regulator of HLA II 252.13 99.25 0.138 558354 RPSA Ribosomalprotein SA 1322.76 86.38 0.034 558360 NDUFB4 NADH dehydrogenase(ubiquinone) 1 beta subcomplex, 4, 15 kDa 211.99 145.77 0.345 558361NME2 Non-metastatic cells 2, protein (NM23B) expressed in 300.76 113.650.276 558362 NUMA1 Nuclear mitotic apparatus protein 1 186.63 72.040.207 558376 RAC1 Ras-related C3 botulinum toxin substrate 1 (rhofamily, small GTP 310.27 151.23 0.000 binding protein Rac1) 558381SNORA65 Small nucleolar RNA, H/ACA box 65 182.13 140.06 0.172 558382RPL15 Ribosomal protein L15 675.76 128.40 0.000 558383 RPL18A Ribosomalprotein L18a 705.56 175.27 0.034 558384 RPL19 Ribosomal protein L19526.89 137.15 0.034 558385 RPL23A Ribosomal protein L23a 699.13 138.420.069 558386 RPL34 Ribosomal protein L34 697.35 378.17 0.069 558388RPS3A Ribosomal protein S3A 2474.40 122.86 0.034 558389 RPS8 Ribosomalprotein S8 962.64 129.92 0.000 558390 RPS24 Ribosomal protein S24 612.43101.36 0.034 558391 RPS26 Ribosomal protein S26 165.48 119.11 0.276558396 SCD Stearoyl-CoA desaturase (delta-9-desaturase) 914.63 104.450.069 558424 CSDA Cold shock domain protein A 226.19 107.82 0.103 558426EIF3S5 Eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa 303.80 92.52 0.172 558429 BUD31 BUD31 homolog (S. cerevisiae) 144.1863.32 0.172 558431 RPL14 Ribosomal protein L14 572.84 76.90 0.069 558442PDCD6IP Programmed cell death 6 interacting protein 197.37 92.14 0.241558448 TXNL2 Thioredoxin-like 2 190.19 99.31 0.276 558453 ATP5L ATPsynthase, H+ transporting, mitochondrial F0 complex, subunit g 303.51169.99 0.172 558454 NUDC Nuclear distribution gene C homolog (A.nidulans) 366.87 118.17 0.207 558458 COPS8 COP9 constitutivephotomorphogenic homolog subunit 8 143.44 86.61 0.207 (Arabidopsis)558473 C18orf10 Chromosome 18 open reading frame 10 143.75 80.47 0.172558499 CD320 CD320 molecule 188.81 75.95 0.379 558511 PARL Presenilinassociated, rhomboid-like 126.27 91.30 0.276 558521 C2orf33 Chromosome 2open reading frame 33 133.19 79.12 0.241 558591 ORMDL1 ORM1-like 1 (S.cerevisiae) 156.16 85.13 0.345 558825 PDE4DIP Phosphodiesterase 4Dinteracting protein (myomegalin) 192.79 111.41 0.241 558995 C1orf151Chromosome 1 open reading frame 151 718.64 244.03 0.103 567260 CD2BP2CD2 antigen (cytoplasmic tail) binding protein 2 161.65 79.42 0.207567263 C1orf43 Chromosome 1 open reading frame 43 337.41 80.70 0.172567267 ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 95.02 60.830.345 567279 SAP30BP SAP30 binding protein 178.67 103.35 0.207 GenomicVariants on Human Genome Assembly Build 36 UniGene SHORT SAGE LONG SAGEAffymetrix Locus cluster Mean CV 0's P Mean CV 0's P Mean CV VariationCytogen ID 120 222.30 77.57 0.000 182.28 77.83 0.000 536.31 44.78CopyNumber 1q25.1 177 142 177.46 78.94 0.036 83.00 75.28 0.000CopyNumber 16p11.2 2900 202 233.57 113.47 0.000 199.28 96.07 0.111419.21 51.49 429 522.98 82.18 0.000 551.21 81.48 0.000 865.18 43.60 695151.39 90.92 0.000 118.87 85.62 0.111 1052.98 100.96 CopyNumber 21q22.33455 808 137.03 66.96 0.000 135.76 77.44 0.222 210.67 38.17 861 68.60107.22 0.000 36.11 50.87 0.222 127.15 87.08 CopyNumber 16p11.2 2903 106396.52 67.18 0.036 100.31 75.40 0.222 194.60 33.14 1103 106.49 111.800.036 125.52 97.41 0.111 106.24 57.23 2430 41.98 80.01 0.071 47.30 88.890.222 218.15 32.90 2533 60.36 77.46 0.071 74.01 77.57 0.111 354.31 47.432795 334.22 95.03 0.000 259.59 82.14 0.111 2250.38 43.77 2853 154.6763.43 0.036 186.93 60.34 0.111 926.32 22.95 3100 67.12 76.40 0.000 61.2467.08 0.222 517.42 29.81 3254 97.41 78.32 0.036 113.88 73.94 0.111211.49 31.45 Inversion 11p15.5 2202 3353 78.09 56.37 0.071 216.42 70.650.000 881.36 27.96 3416 109.67 131.08 0.036 68.67 112.87 0.222 360.44151.18 CopyNumber 9p22.1 1912 3439 70.64 80.75 0.036 89.54 93.24 0.111191.34 38.33 3530 79.35 72.15 0.036 108.31 56.32 0.000 136.00 30.88 398998.71 108.38 0.036 134.74 83.01 0.111 427.22 43.37 4055 257.29 135.830.000 441.94 118.93 0.111 64.49 38.32 4742 107.98 119.15 0.036 39.7165.93 0.222 275.64 44.77 CopyNumber 8q24.3 1879 4747 62.19 73.50 0.07171.07 73.04 0.111 307.46 47.47 4766 55.17 86.86 0.036 72.60 84.36 0.222262.05 27.51 4859 101.90 103.29 0.071 110.40 111.52 0.000 299.38 40.444997 65.10 62.12 0.000 50.72 94.59 0.111 264.44 22.10 4998 60.81 63.220.036 28.78 51.61 0.222 229.36 56.84 5062 333.07 101.42 0.000 111.8281.88 0.111 800.47 52.13 CopyNumber 15q24.3 2811 5086 62.72 72.25 0.03653.42 73.36 0.222 135.70 28.77 5120 212.71 71.64 0.000 204.68 69.540.111 1158.59 29.63 5158 163.14 67.54 0.000 138.55 60.73 0.111 383.9536.39 5245 64.41 74.90 0.000 80.69 73.69 0.000 219.54 21.60 5258 122.1384.40 0.071 133.74 77.92 0.111 589.76 55.05 5268 71.67 78.70 0.000 46.2573.83 0.111 113.40 37.54 5298 78.91 59.08 0.000 58.54 49.70 0.111 296.1131.82 5308 354.49 83.81 0.000 479.50 73.38 0.000 2422.20 38.02 532473.70 64.23 0.000 62.22 66.74 0.111 694.81 25.69 5345 69.83 86.81 0.07161.41 84.79 0.111 73.49 30.51 CopyNumber 2q37.3 515 5662 632.04 87.260.000 651.22 57.10 0.000 2861.36 36.28 5710 58.67 67.53 0.071 34.1380.74 0.111 452.86 45.78 5719 289.65 94.26 0.000 65.99 56.36 0.000 55.5345.18 CopyNumber 12p13.31 2368 5912 53.23 65.61 0.000 30.20 60.87 0.111430.78 30.03 5947 44.57 68.42 0.036 34.91 59.37 0.222 368.59 33.28 6396138.04 72.90 0.036 94.01 39.56 0.222 869.88 31.02 6454 233.69 77.380.000 290.31 91.04 0.000 504.85 40.25 CopyNumber 19p13.12 3223 6459117.70 121.97 0.036 88.34 85.38 0.111 157.79 41.08 CopyNumber 8q24.31880 6551 113.84 102.10 0.000 99.28 83.28 0.000 515.56 45.37 6891 113.9368.55 0.000 79.36 95.32 0.000 437.26 34.58 7101 57.03 85.77 0.071 81.0484.26 0.000 183.19 27.20 7236 73.56 91.55 0.000 89.02 123.50 0.111150.63 53.39 CopyNumber 19q13.33 3277 7476 134.42 85.55 0.000 91.4867.53 0.000 1250.83 39.30 7527 91.89 92.63 0.036 52.36 54.01 0.222 97.4336.93 7744 253.95 85.28 0.000 77.42 71.13 0.000 415.46 37.27 CopyNumber11q13.1-11q13.2 2278 7753 200.10 136.12 0.000 138.00 85.95 0.111 100.6548.84 CopyNumber 7q32.1 1639 7768 81.86 65.21 0.000 63.80 65.95 0.111269.17 27.39 CopyNumber 11q13.1 2276 7862 93.55 74.15 0.036 84.67 63.850.111 7910 165.96 72.05 0.036 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2912 556267 39.65 68.11 0.036 37.29 76.22 0.222556461 99.23 109.80 0.000 89.26 94.15 0.111 556795 122.76 113.17 0.071222.20 105.92 0.111 557550 707.78 90.20 0.000 781.42 91.24 0.000 2030.9930.63 558296 76.31 65.84 0.000 71.76 64.47 0.222 293.40 20.63 CopyNumber2p25.3 261 558313 268.12 83.46 0.000 103.84 61.28 0.111 558322 725.9381.02 0.000 781.10 60.08 0.000 558325 121.20 58.04 0.071 105.00 59.170.000 558328 88.77 175.31 0.071 41.72 74.68 0.222 724.52 77.69CopyNumber 6p21.31 1321 558330 1268.35 119.70 0.000 1306.25 81.82 0.000CopyNumber 19q13.33 3275 558338 259.73 94.69 0.000 392.75 84.14 0.111558345 52.12 68.96 0.036 47.70 48.55 0.222 558354 2215.71 85.28 0.0003392.33 80.75 0.000 558360 213.80 85.52 0.000 198.33 51.08 0.111 558361377.22 86.68 0.000 276.67 71.79 0.111 558362 70.26 74.08 0.036 45.5964.87 0.222 229.35 49.45 558376 423.24 55.75 0.000 528.10 45.88 0.000558381 167.44 127.10 0.000 52.20 90.63 0.000 558382 247.73 62.95 0.036245.75 66.13 0.111 558383 1510.30 92.57 0.000 850.60 69.48 0.111 558384913.52 70.50 0.000 972.23 66.45 0.000 CopyNumber 17q12 3020 558385591.06 76.67 0.000 522.14 55.82 0.111 558386 994.94 70.79 0.000 1008.3763.71 0.000 558388 1599.66 76.32 0.000 1561.96 59.50 0.000 5583891884.53 86.31 0.000 2526.25 46.00 0.000 558390 1096.04 76.07 0.000653.91 60.77 0.000 558391 1253.30 71.38 0.000 1018.49 62.26 0.000 558396153.06 101.60 0.071 177.30 89.88 0.222 187.47 100.01 558424 153.84 92.400.000 144.32 74.76 0.000 558426 111.38 67.09 0.036 90.90 62.22 0.111558429 74.41 78.14 0.036 73.01 72.78 0.111 CopyNumber 7q22.1 1597 558431374.90 100.68 0.000 155.33 60.37 0.000 558442 62.39 68.18 0.000 51.4569.20 0.000 558448 111.05 67.59 0.000 46.04 58.06 0.111 558453 614.0882.84 0.000 530.26 57.92 0.000 558454 97.57 75.98 0.000 112.20 87.340.111 CopyNumber 1p36.11 49 558458 41.97 67.67 0.071 35.79 63.61 0.111558473 66.89 70.64 0.000 40.37 55.42 0.222 104.21 36.46 CopyNumber18q12.2 3132 558499 45.84 78.66 0.071 43.18 52.43 0.222 69.81 63.34CopyNumber 19p13.2 3210 558511 60.47 54.61 0.000 46.40 50.18 0.222558521 84.37 78.28 0.000 61.92 65.33 0.111 558591 92.26 68.02 0.07185.80 56.76 0.111 687.61 32.03 558825 95.41 107.55 0.000 42.12 72.580.000 CopyNumber 1q21.1 147 558995 115.01 53.36 0.000 186.71 64.24 0.111567260 55.10 63.25 0.036 44.20 70.83 0.222 14.03 385.13 CopyNumber16p11.2 2903 567263 106.63 62.05 0.000 93.74 61.88 0.222 27.38 49.92567267 74.61 57.55 0.036 44.12 65.62 0.000 26.18 56.35 567279 55.8365.02 0.036 43.97 59.48 0.111 CopyNumber 17q25.1 3074 Mean: mean geneexpression level, CV: coefficient of variation, 0's P: 0's proportion

Example 3: Identification of ERG

Among the candidate ERGs, reference genes were further identifiedaccording to the following process.

First, CVs were calculated for each UniGene cluster in the datasetsincluding EST, ShortSAGE, LongSAGE and microarray (Affymetrix HG-U133,CA), and genes were preferentially ranked in ascending order of CV. Outof the 400 genes (approx. 20% of the candidate ERG) which werepreferentially ranked in ascending order of CV from each dataset, 13ERGs were found to be common to all four datasets (Table 3). The 13 ERGswere identified as Accession No. Hs 500775(ZNF207), Accession No. Hs446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs494985(FBXW2) and Accession No. Hs 242458(SPG21).

The gene ontology thereof was determined from a Gene Ontology site(http://www.geneontology.org/).

Most of the identified genes (ZNF207, OAZ1, CTBP1, PAPOLA, and FBXW2)were involved in basic cellular physiological processes, particularly incellular metabolic processes. TRIM27 and CUL1 are genes responsible forcell proliferation. OAZ1 showed the lowest CV in both ShortSAGE andLongSAGE. CTBP1 and ZNF207 were the most stable genes in CGAP andMicroarray, respectively. OAZ1, which is involved in polyaminebiosynthesis, showed the highest expression across all four datasets,with relatively low CV in all datasets except for the EST dataset.

Experimental Example 4: Correlation Analysis of Reference Gene BetweenDatasets

Pearson and Spearman's rank correlation analyses were performed on theERGs identified according to the present invention in a manner similarto that of Experimental Example 2 to compare the four datasets in termsof gene expression and CV.

Significant correlations between expression values were observed withinsome of the datasets, whereas no significant correlations of CV betweenany of the datasets were observed.

Although the Spearman correlation between EST-Microarray (0.374,P=0.206) and ShortSAGE-Microarray (0.511, P=0.076) was not significant,the gene expression of the 13 ERGs showed a significant Pearsoncorrelation (p<0.001). No significant correlation in CV was foundbetween the datasets (P>0.05). With the respective transcripts thereoffound in all tissues in both ShortSAGE and LongSAGE, CDC42 and MYL6 weremost stably expressed among the ERGs. HBP1 and PSMC1 showed the lowestCV in EST and Microarray.

Experimental Example 5: Comparison Between Novel Reference Gene andTraditional Reference Gene in Gene Expression Datasets

The 13 endogenous reference genes identified according to the presentinvention were compared with 13 traditional reference genes (Table 4) interms of gene expression level and CV.

As a result, the six traditional endogenous reference genes, RPLP0,ACTB, PPIA, GAPD, PGK1 and B2M, showed high expression levels, while theother genes, GUSB, HPRT1, TBP, TFRC, ALAS1, H6PD and HMBS, exhibitedrelatively low expression levels, in all four datasets (FIG. 6). Theseresults are in line with those of the previous report, in whichpotential endogenous expression genes were analyzed for mRNA level usingqRT-PCR (Radonic A et al., Biochem Biophys Res Commun, 313(4), 856-862,2004). The expression levels of the endogenous reference genesidentified according to the present invention were similar to orslightly higher than those of the low-abundance group of the traditionalendogenous reference genes.

In addition, all of the endogenous reference genes identified accordingto the present invention, except for a few, showed lower CV values thantraditional reference genes (FIG. 7). In other words, the endogenousreference genes of the present invention are generally low in expressionvariation across a wide range of tissues, indicating that the identifiedreference genes according to the present invention are more stablyexpressed than traditional endogenous reference genes.

TABLE 3 ERGs identified from four datasets UniGene EST SHORT SAGE LONGSAGE Affymetrix Gene Ontology cluster Symbol Gene Title Mean CV 0's PMean CV 0's P Mean CV 0's P Mean CV Biological Process MolecularFunction Hs.446427 OAZ1 Ornithine decarboxylase 673.68 62.71 0.069576.39 55.94 0 444.92 41.01 0 1860.9 22.07 Polyamine biosynthesisOrnithine decarboxylase antizyme 1 inhibitor activity Hs.9589 UBQLN1Ubiquilin 1 111.34 60.19 0.31 75.93 61.3 0.036 71.77 49.75 0.111 919.3226.81 Kinase binding Hs.444279 GPBP1 GC-rich promoter 132.98 56.92 0.24163.11 61.65 0 80.72 51.79 0.111 746.56 26.6 binding protein 1 Hs.208397CTBP1 C-terminal binding 136.74 48.53 0.138 213.99 62.01 0 112.96 50.6 0481.51 24.72 Negative regulation of cell Protein C-terminus protein 1proliferation; Protein binding: Transcription phosphorylation; Viralfactor binding genome replication Hs.253726 PAPOLA Poly(A) polymerase216.15 65.36 0.172 118.24 58.02 0 89.5 50.88 0 451.23 27.68 mRNApolyadenylation RNA binding alpha Hs.250009 ARL8B ADP-ribosylationfactor- 132.27 35.79 0.379 134.21 61.55 0 59.19 55.14 0.111 418.28 26.81Chromosome segregation α-tubulin binding; like 8B β-tubulin binding; GDPbinding: GTP binding; GTPase activity Hs.242458 SPG21 Spastic paraplegia21 120.35 59.44 0.31 76.41 57.83 0.036 73.3 49.12 0 415.64 29.35 Antigenreceptor-mediated CD4 receptor binding (autosomal recessive, signallingpathway Mast syndrome) Hs.530118 LUC7L2 LUC7-like 2 (S. 132.76 59.550.172 74.65 63.41 0 57.21 50.39 0.111 386.79 22.9 cerevisiae) Hs.500775ZNF207 Zinc finger protein 207 233.29 62.27 0.034 165.68 56.77 0 154.3252.88. 0.111 358.69 18.38 Regulation of transcription, Transcriptionfactor DNA-dependent activity: Zinc ion binding Hs.533222 DIMT1L DIM1dimethyladenosine 129.17 69.14 0.379 42.41 60.55 0.071 36.87 44.13 0.111164.72 28.3 transferase 1-like (S. cerevisiae) Hs.440382 TRIM27Tripartite motif 155.33 68.54 0.172 80.66 63.06 0 67.84 43.41 0.111163.6 26.3 Cell proliferation; Metal ion binding: containing 27Spermatogenesis Transmembrane receptor protein tyrosine kinase activityHs.146806 CUL1 Culin 1 120.27 57.5 0.207 69.33 63.76 0.036 76.43 550.111 156.47 27.78 Cell cycle arrest: G1/S Protein binding transition ofmitotic cell cycle; Induction of apoptosis by intracellular signals;Negative regulation of cell proliferation Hs.494985 FBXW2 F-box andWD-40 97.45 68.65 0.379 40.27 58.47 0 23.54 51.61 0.111 69.32 28.36Proteolysis Protein binding: ubiquitin domain protein 2 conjugatingenzyme activity: ubiqiutin-protein ligase activity Mean: Mean geneexpression level, CV: Coefficient of variation, 0's P: 0's proportion

TABLE 4 Traditional ERGs used in present invention UniGene EST SHORTSAGE cluster Symbol Gene Title Mean CV 0's P Mean CV 0's P Hs.448226RPLP0 Ribosomal protein, large, 3,809.2 75.92 0 1,108.65 91.01 0 P0Hs.520640 ACTB β-actin 4,381.34 95.98 0.034 1,348.49 91.02 0 Hs.356331PPIA Peptidylprolyl isomerase 1,225.7 78.02 0.034 1,646.83 59.53 0 A(cyclophilin A) Hs.479728 GAPDH Glyceraldehyde-3- 7,330.72 80.18 03,167.05 83.62 0 phosphate dehydrogenase Hs.78771 PGK1 Phosphoglyceratekinase 681.19 86.72 0.034 423.67 85.52 0 1 Hs.534255 B2Mβ-2-microglobulin 1,303.98 172.16 0 2,594.12 96.87 0 Hs.255230 GUSBβ-Glucuronidase 116.77 89.37 0.414 40.98 67.81 0.107 Hs.412707 HPRT1Hypoxanthine 103.48 63.18 0.345 32.51 63.51 0.107phosphoribosyltransferase 1 Hs.1100 TBP TATA box binding 71.46 47.770.448 31.94 62.8 0.286 protein Hs.529618 TFRC Transferrin receptor212.76 85.52 0.241 89.51 87.09 0.036 (p90, CD71) Hs.82609 HMBSHydroxymethylbilane 176.26 105.68 0.172 32.51 76.51 0.214 synthaseHs.463511 H6PD Hexose-6-phosphate 101.9 86.9 0.483 44.65 70.8 0.071dehydrogenase (glucose- 1-dehydrogenase) Hs.476308 ALAS1δ-Aminolevulinate 132.82 82.5 0.345 50.43 72.23 0 synthase 1 UniGeneLONG SAGE Affymetrix cluster Mean CV 0's P Mean CV Hs.448226 1,605.7674.12 0 1,888.46 41.47 Hs.520640 1,961.29 60.59 0.111 5,036.63 31.42Hs.356331 1,683.27 56.79 0 5,223.43 28.46 Hs.479728 3,178.15 102.5 04,934.56 42.86 Hs.78771 445.96 90.9 0 1,179.63 41.05 Hs.534255 2,910.69103.61 0 4,736.9 32.54 Hs.255230 11.42 89.36 0.556 360.37 49.14Hs.412707 33.29 49.07 0.222 233.36 40.85 Hs.1100 17.58 69.22 0.444 25.4473.23 Hs.529618 82.62 91.59 0.111 36.01 56.84 Hs.82609 28.04 42.5 0.444119.08 33.63 Hs.463511 25.33 101.45 0.222 25.04 28.85 Hs.476308 22.550.59 0.222 178.95 107.93 Mean: Mean gene expression level, CV:Coefficient of variation, 0's P: 0's proportion

Experimental Example 6: Gene Copy Number Variations of ERGs

The 13 ERGs identified according to the present invention were examinedfor gene copy number variation with reference to the Database of GenomicVariants (http://projects.tcag.ca/variation/). Only OAZ1 and DIMT1L,among the 13 genes of the present invention, were found in chromosomeregions known to exhibit gene copy number variation (Table 5). Incontrast, many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) of thetraditional reference genes were located at such genomic loci (Table 5).These results suggest that almost all of the identified reference genesof the present invention, except for the two genes, can be used as guidegenes for the measurement of gene amplification because they might behighly unlikely to show variation in gene copy number.

Experimental Example 7: Validation of Reference Gene

<7-1> Validation of Expression Level of ERG by Quantitative RT-PCR(qRT-PCR)

For use in validating the expression stability of the ERGs identifiedfrom the datasets, a total of 108 human samples, including 26 frozenhuman tissues, 60 formalin-fixed, paraffin embedded (FFPE) humantissues, and 22 human cancer cell lines were obtained (Table 6). The 60FFPE tissues were composed of 10 breast cancer tissues, 8 normal stomachtissues, 9 stomach cancer tissues, 10 normal ovary tissues, 4 ovariandropsy tissues, 9 borderline ovarian tumors, and 10 ovarian cancertissues. Total RNA was isolated from these tissues and cell lines. Forfrozen human tissues and human cancer cell line samples, RNA which metthe requirements of A260/280≧1.80 and rRNA (28S/18S)≧1.0 was used inqRT-PCR. cDNA was synthesized from the RNA using a standard techniqueand then diluted in distilled water (1:3 cDNA:DW) before qRT-PCR. PCRprimers are summarized, together with the Universal Probe Library (UPL)thereof, in Table 7, below.

For use in this qRT-PCR, traditional ERGs were selected on the basis ofthe use frequency in previous reports and commercially available kitsand the CV calculated from the database of the present invention. The 8ERGs (B2M, ACTB, GAPDH, HMBS, PPIA, HPRT1, TBP and H6PD) that are mostwidely used can be found in commercially available kits such as Taqmanhuman endogenous control plate (Applied Biosystems) and HKG selectionkit (Roche Applied Science, Ohl F et, al., J Mol Med 83:1014-24, 2005;Roche Applied Science Technical Note No. LC 15/2005; Applied Biosystems,2001). Each gene was measured at 530 nm using an FAM-conjugate UPL probe(Roche Applied Science) or a custom-made specific probe (TIB MOLBIOLGmbH, Germany). All PCR was performed in a Lightcycler 2.0 (RocheApplied Science, USA) using standard protocols.

PCR efficiency for each gene was measured using a cDNA serial dilution(Pfaffl M W et al., Nucleic Acids Res 29: e45, 2001) of the stomachcancer cell line MKN74 and calculated with Lightcycler software 4.0(Roche Applied Science, USA). It was found to fall within a range from90 to 100% (Table 8).

Also, PCR efficiency for each probe in tissue samples was estimatedusing a LinRegPCR program (Ramakers C et al., Neurosci Lett 339:62-6,2003). A Cp value is an average of three measurements for each gene. Thesame genes from different tissue samples were measured under the samePCR conditions so as to minimize experimental variation. Because it wasnot measured in any of 4 samples, normal lung, liver, breast and kidneytissues, the Cp value of H6PD was omitted from subsequent calculations.For each experiment that was conducted in triplicate, the Cp values werefound to have a CV less than 5%.

Expression levels of 20 genes, except for H6PD, across 48 samples,including frozen human tissues and cancer cell lines, are depicted inFIG. 8. The 13 novel ERGs of the present invention were expressed in all48 samples. 7 traditional ERGs showed a wide expression range (Cp:13.52˜29.39) whereas H6PD was not found in some tissues. The 13 ERGsranged in Cp from 18.90 to 28.79 (FIG. 9). Traditional ERGs can beclassified into a high-expression group (median<20 cycles) and alow-expression group (median>23 cycles). B2M, PPIA, GAPDH and ACTB areincluded in the high-expression group and HPRT1, TBP, and HMBS are foundin the low-expression group. All of the novel ERGs of the presentinvention, except for OAZ1, show expression levels between those of thehigh-expression group and the low-expression group of the traditionalERGs. ZNF2007 had the highest expression level among the ERGs, followedby UBQLN1 and CUL1. OAZ1 had the lowest expression level.

TABLE 5 Gene copy number variations of traditional ERG and novel ERGNovel candidate ERGs Traditional ERGs Gene Genomic Genomic Variation**Gene Genomic Genomic Variation** Symbol location* Variation type LocusID References symbol location* Variation type Locus ID References ZNF20717q11.2 RPLP0 12q24.23 OAZ1 19p13.3 Copy number 3199 Wong et al (2007)ACTB 7p22.1 Copy number 1487 Wong et al (2007) LUC7L2 7q34 PPIA 7p13CTBP1 4p16.3 GAPDH 12p13.31 Copy number 2368 Redon et al (2006) TRIM276p22.1 PGK1 Xq21.1 Copy number 3567 Iafrate et al (2004) GPBP1 5q11.2B2M 15q21.1 Copy number 2773 Redon et al. (2006) UBQLN1 9q21.33 GUSB7q11.21 ARL8B 3p26.1 HPRT1 Xq26.2 PAPOLA 14q32.2 TBP 6q27 Copy number1479 Redon et al (2006) CUL1 7q36.1 TFRC 3q29 Copy number 753 Iafrate etal (2004) Copy number Redon et al. (2006) DIMT1L 5q12.1 Copy number 1137Redon et al (2006) HMBS 11q23.3 FBXW2 9q33.2 H6PD 1p36.22 SPG21 15q22.31ALAS1 3p21.2 Copy number 590 Wong et al (2007) *Genomic location wassearched from Ensembl (http://www.ensembl.org/index.html) **Genomicvariations were searched in the Database of Genomic Variants(http://projects.tcag.ca/variation/, Human Genome Assembly Build 36(hgl8)).

<7-2> Validation of ERG Using Expression Stability Based on qRT-PCR Data

Gene expression stability was analyzed using geNorm v3.4 software(Vandesompele J et al., Genome Biol 3:RESEARCH0034, 2002) and NormFindersoftware (Andersen C L et al., Cancer Res 64:5245-50, 2004). For geNormand NormFinder analysis, Cp values were converted into relativeexpression levels in consideration of the PCR efficiencies of genesshown in Table 8 (GeNorm software manual, update on Sep. 6, 2004.//medgen.ugnet.be/˜jvdesomp/genorm/).Relative expression was calculatedaccording to the following Mathematical Formula 4.

Relative Expression=(1+E)^(ΔCp)  <Mathematical Formula 4>

-   -   ΔCp=Minimum Cp−Sample Cp;    -   Minimum Cp=lowest Cp value; and    -   E=PCR Efficiency

Correlation between the gene expression stability calculated with thegeNorm or NormFinder program (M by geNorm, S by NormFinder) and the CVcalculated in each dataset was analyzed with R analysis software(//www.R-project.org).

All of the genes were found to have M values (<0.9) lower than thedefault limit, 1.5, of geNorm, with high expression stability, asanalyzed using the geNorm program (Table 9). Lower M values for meanexpression stability mean more stable expression. GPBP1 and CUL1 wereobserved to show the most stable expression. Among the genes analyzed,B2M is the lowest stable expression gene, with the highest M value of0.888, followed by ACTB (M=0.843), HMBS (M=0.815) and GAPDH (M=0.793) indescending order of expression instability.

When using the NormFinder program, TBP and PAPOLA were ranked as the toptwo in terms of expression stability (Table 9). Consistent with thegeNorm result, B2M, ACTB, GAPDH, HMBS and HPRT1 were found to be lessstable in expression level than the novel ERGs of the present invention.Both programs demonstrated that most of the novel ERGs identifiedaccording to the present invention show more stable expression levelsthan do traditional ERGs. Further, when analyzed for gene expressionstability using a LinRegPCR program on the basis of the relativeexpression calculated with PCR efficiency, most novel ERGs were found tomaintain higher expression stability than traditional ERGs.

There is no significant correlation between the M values calculated withgeNorm and the CV values in Microarray and LongSAGE (p>0.05), whereassignificance was found in correlation between M values and CV values inEST (Pearson correlation coefficient: 0.676, p=0.001) and ShortSAGE(Pearson correlation coefficient: 0.659, p=0.002). Likewise, as for theStability values (S), calculated with NormFinder, significantcorrelation was found in EST, ShortSAGE and LongSAGE, but not inmicroarray. Both the M and the S values showed higher agreement with CVin EST and ShortSAGE than in Affymetrix (Table 10).

Furthermore, the 13 novel ERGs were analyzed for expression in 60 FFPEsamples using qRT-PCR in order to examine the possibility of applyingthem to the tissues in which high RNA degradation occurs. All of thegenes, except for DIMT1L, were found to be expressed in all 60 samples.Cp was observed to range from 18.85 to 33.02 for traditional ERGs andfrom 23.33 to 31.38 for the novel ERGs (FIG. 9). Because of the lack ofamplification in 5 samples, DIMT1L was omitted from subsequent stabilityanalyses. Despite difference in the type of samples used in theexperiments, almost all genes, except for several genes, were observedto be expressed in a pattern similar to that observed in the previous 48samples. These results indicate that the novel ERGs of the presentinvention can be applied to gene expression in FFPE samples. geNorm andNormFinder analyses demonstrate that most of the novel ERGs are morestably expressed with lower Cp values in FFPE samples, as well as in the48 samples, than are traditional ERGs (Table 9).

TABLE 6 Human tissues and cancer cell lines used in Real time-PCR Tissueor cell Normal(N)/ No. lines Type Tumor(T) Diagnosis Remarks 1 Adrenalgland frozen tissue N Normal 2 Brain frozen tissue N Normal 3 Breastfrozen tissue N Normal 4 Colon frozen tissue N Normal Normal tissueadjacent to signet ring cell carcinoma, ascending colon 5 Esophagusfrozen tissue N Normal 6 Kidney frozen tissue N Normal 7 Liver frozentissue N Normal 8 Lung frozen tissue N Normal 9 Omentum frozen tissue NNormal 10 Ovary frozen tissue N Normal 11 Placenta frozen tissue NNormal 12 Placenta frozen tissue N Normal Immature placenta with focalintervillous calcifications, normal two umbilical arteries and one vein,and no evidence of chorioamnionitis 13 Rectum frozen tissue N Normal 14Salivary gland frozen tissue N Normal 15 Thyroid gland frozen tissue NNormal 16 Tonsil frozen tissue N Normal 17 Uterus frozen tissue N Normal18 Vein frozen tissue N Normal 19 Vulva frozen tissue N Normal 20 Brainfrozen tissue T Glioblastoma mulfiforme 21 Breast frozen tissue TInvasive ductal carcinoma, upper central 22 Transverse colon frozentissue T Ulcerofungating carcinoma, transverse colon, Mucinousadenocarcinoma 23 Lung frozen tissue T Pleomorphic carcinoma 24 Ovaryfrozen tissue T Transitional cell carcinoma, bilateral ovaries 25 Rectumfrozen tissue T Adenocarcinoma, moderately differentiated with mucinproduction 26 Stomach frozen tissue T Advanced gastric carcinoma,Tubular adenocarcinoma, M/D 27 HL-60 cell lines T Leukemia Blood 28MDA-MB-231 cell lines T Breast cancer Breast 29 C33A cell lines TCervical cancer Cervix 30 HeLa cell lines T Cervical cancer 31 HCC-44cell lines T Lung cancer Lung 32 A549 cell lines T Lung cancer 33 Caov3cell lines T Ovarian cancer Ovary 34 OV-90 cell lines T Ovarian cancer35 OVCAR3 cell lines T Ovarian cancer 36 SK-OV3 cell lines T Ovariancancer 37 SNU119 cell lines T Ovarian cancer 38 SW626 cell lines TOvarian cancer 39 AGS cell lines T Gastric cancer Stomach 40 Kato IIIcell lines T Gastric cancer 41 MKN1 cell lines T Gastric cancer 42 MKN74cell lines T Gastric cancer 43 NCI-N87 cell lines T Gastric cancer 44SNU5 cell lines T Gastric cancer 45 SNU16 cell lines T Gastric cancer 46SNU484 cell lines T Gastric cancer 47 SNU601 cell lines T Gastric cancer48 SNU638 cell lines T Gastric cancer * Normal tissue adjacent to signetring cell carcinoma, ascending colon; and ** immature placenta withfocal intervillous calcifications, normal two umbilical arteries and onevein, and no evidence of chorioamnionitis.

TABLE 7 Primers and Taqman Probes for Real-Time PCR Gene UPL PrimersProduct Names No. Sense Primers Anti-Sense Primers (bp) GAPDH 60SEQ ID NO. 1: SEQ ID NO. 2: 66 agccacatcgctcagaca gcccaatacgaccaaatccACTB 64 SEQ ID NO. 3: SEQ ID NO. 4: 97 ccaaccgcgagaagatgaccagaggcgtacagggatag B2M 42 SEQ ID NO. 5: SEQ ID NO. 6: 86ttctggcctggaggctatc tcaggaaatttgactttccattc PPIA # SEQ ID NO. 7:SEQ ID NO. 8: 326 catctgcactgccaagactgag tgcaatccagctaggcatg HPRT1 73SEQ ID NO. 9: SEQ ID NO. 10: 102 tgaccttgatttattttgcatacccgagcaagacgttcagtcct HMBS 26 SEQ ID NO. 11: SEQ ID NO. 12: 92tgtggtgggaaccagctc tgttgaggtttccccgaat TBP 3 SEQ ID NO. 13:SEQ ID NO. 14: 60 gctggcccatagtgatcttt cttcacacgccaagaaacagt H6PD 89SEQ ID NO. 15: SEQ ID NO. 16: tggagatcatcatgaaagagacgcgaatgacaccgtactcct 74 c ZNF207 27 SEQ ID NO. 17: SEQ ID NO. 18: 65ctgtttcctagcacagcacaa ggtttgaaatctgtaccaacagg OAZ1 74 SEQ ID NO. 19:SEQ ID NO. 20: 67 caccatgccgctcctaag gagggagaccctggaactct LUC7L2 85SEQ ID NO. 21: SEQ ID NO. 22: 60 cgatcacacagcaagaatccagatcgatgtctgcgatgc CTBP1 77 SEQ ID NO. 23: SEQ ID NO. 24: 86actgcgtgaccctgcact gccccttgtctcatctgc TRIM27 7 SEQ ID NO. 25:SEQ ID NO. 26: 71 caggcacgagctgaactct agctgctcaaactcccaaac GPBP1 4SEQ ID NO. 27: SEQ ID NO. 28: 75 tcacttgaggcagaacacagaagcacatgtttcatcattttcac UBQLN1 73 SEQ ID NO. 29: SEQ ID NO. 30: 92gaatcctgaccttgctgcac ttgggagctgttgtctcattt ARL8B 82 SEQ ID NO. 31:SEQ ID NO. 32: 66 aagcatgtgggagcggtat cgatctgcagcatctatcatgt PAPOLA 78SEQ ID NO. 33: SEQ ID NO. 34: 91 gctacgaagaccagtccattgtgttggtcacagatgctgct CUL1 65 SEQ ID NO. 35: SEQ ID NO. 36: 86gcgaggtcctcactcagc ttctttctcaattagaatgtcaatgc DIMT1L 77 SEQ ID NO. 37:SEQ ID NO. 38: 75 tccagtgttgtaaggatagaacc Ccttactagaccatcccattcct taagFBXW2 3 SEQ ID NO. 39: SEQ ID NO. 40: 111 cggctctgcagacttcactttgcacttctgcaaaactacct SPG21 21 SEQ ID NO. 41: SEQ ID NO. 42: 88gatgtctttttccggcagat cgagatggtcccaataaactg

TABLE 8 PCR Efficiency of Genes UPL Probe PCR Efficiency PCR EfficiencyGene Name Nos. (Diluted)* (LinRegPCR)** GAPDH 60 1.899 1.735 ±0.048(137) ACTB 64 2.038 1.491 ± 0.034(137) B2M 42 1.868 1.717 ±0.068(140) PPIA # 1.877 1.773 ± 0.058(142) HPRT1 73 1.800 1.771 ±0.024(143) HMBS 26 1.954 1.431 ± 0.031(143) TBP 3 1.826 1.447 ±0.038(142) H6PD 89 1.874 1.832 ± 0.026(64)  ZNF207 27 1.869 1.648 ±0.018(142) OAZ1 74 2.068 1.498 ± 0.059(142) LUC7L2 85 1.829 1.709 ±0.047(143) CTBP1 77 2.064 1.651 ± 0.055(141) TRIM27 7 1.908 1.693 ±0.034(143) GPBP1 4 1.844 1.715 ± 0.031(141) UBQLN1 73 1.864 1.723 ±0.027(143) ARL8B 82 1.838 1.499 ± 0.074(139) PAPOLA 78 1.830 1.509 ±0.032(141) CUL1 65 1.810 1.695 ± 0.027(139) DIMT1L 77 1.906 1.655 ±0.037(141) FBXW2 3 1.891 1.638 ± 0.02(142)  SPG21 21 1.826 1.636 ±0.021(142) *PCR Efficiency; calculated with Roche Lightcycler software4.0 using serial diluted cDNA of MKN 74 stomach cancer cell line; **PCREfficiency; calculated with LinRegPCR(Ramakers et al., Neurosci Lett339(1): 62-66, 2003); and, #: F-ttcttgctggtcttgccatTcctgga-p; T:TAMRA-labeled; F: FAM-labeled; P: phosphate.

TABLE 9 Expression Stability of Novel and Traditional ERGs Calculated bygeNorm and NormFinder based on Real-Time PCR Data 48 Samples 60 FFPESamples* GeNorm NormFinder GeNorm NormFinder Genes M Genes S Genes MGenes S GPBP1 0.496 TBP 0.276 GPBP1 0.409 ARL8B 0.233 CUL1 PAPOLA 0.280PAPOLA LUC7L2 0.235 PAPOLA 0.536 CUL1 0.287 ARL8B 0.437 OAZ1 0.247 TBP0.548 LUC7L2 0.290 CTBP1 0.454 CTBP1 0.251 LUC7L2 0.565 CTBP1 0.312LUC7L2 0.483 UBQLN1 0.273 TRIM27 0.585 GPBP1 0.317 SPG21 0.509 SPG210.280 FBXW2 0.597 TRIM27 0.317 FBXW2 0.528 FBXW2 0.286 CTBP1 0.608 FBXW20.329 OAZ1 0.545 PAPOLA 0.290 UBQLN1 0.623 DIMT1L 0.364 UBQLN1 0.555TRIM27 0.327 DIMT1L 0.637 PPIA 0.383 TRIM27 0.567 GPBP1 0.345 PPIA 0.661UBQLN1 0.398 TBP 0.580 HPRT1 0.368 OAZ1 0.682 OAZ1 0.438 CUL1 0.593 CUL10.383 ZNF207 0.709 ARL8B 0.494 HPRT1 0.609 TBP 0.402 ARL8B 0.731 SPG210.502 ZNF207 0.625 HMBS 0.407 SPG21 0.749 ZNF207 0.502 HMBS 0.641 ZNF2070.440 HPRT1 0.770 HPRT1 0.516 GAPDH 0.668 PPIA 0.461 GAPDH 0.793 HMBS0.587 PPIA 0.692 GAPDH 0.527 HMBS 0.815 GAPDH 0.591 B2M 0.715 B2M 0.530ACTB 0.843 ACTB 0.618 ACTB 0.737 ACTB 0.541 B2M 0.888 B2M 0.815 *DIMT1Lwas excluded from the analysis. M: mean expression stability calculatedwith geNorm program; S: Stability calculated with NormFinder program.

TABLE 10 Correlation between CV in each dataset and expression stabilitycalculated with geNorm and NormFinder EST-M EST-S ShortSAGE-MShortSAGE-S LongSAGE-M LongSAGE-S Affy-M Affy-S M-S Pearson 0.676 0.7920.659 0.75 0.427 0.561 0.039 0.017 0.953 P value 0.001 <0.001 0.002<0.001 0.061 0.01 0.869 0.944 <0.001 Spearman 0.589 0.605 0.277 0.2680.092 0.105 0.424 0.357 0.955 P value 0.006 0.005 0.237 0.254 0.7010.661 0.063 0.123 <0.001 Pearson 0.623 0.626 0.656 0.737 0.481 0.6720.243 0.335 0.852 P value 0.004 0.004 0.002 <0.001 0.037 0.002 0.3170.161 <0.001 Spearman 0.663 0.596 0.515 0.502 0.374 0.567 0.521 0.5830.841 P value 0.002 0.008 0.024 0.03 0.115 0.013 0.022 0.009 <0.001 M:Mean expression stability calculated with geNorm; S: Stabilitycalculated with NormFinder

TABLE 11 List of 567 Samples Including 13 Tissues in HG-U133 Array Nos.of Tissues Categories Morphology Samples Brain Benign Meningioma 7 23Malignant Glioblastoma Multiforme 7 Oligodendroglioma 6 Medulloblastoma3 Breast Normal Normal Tissue 18 74 Malignant Infiltrating DuctCarcionma 36 Infiltrating Duct and Lobular Carcinoma 7 InfiltratingLobular Carcinoma 13 Colon Normal Normal Tissue 22 62 MalignantAdenocarcinoma 33 Mucinous Adenocarcinoma 7 Esophagus Normal NormalTissue 11 17 Malignant Adenocarcinoma 6 Kidney Normal Normal Tissue 2651 Benign Oncocytoma 5 Malignant Clear Cell Adenocarcinoma 6 Renal CellCarcinoma 14 Liver Normal Normal Tissue 10 29 Malignant HepatocellularCarcinoma 19 Lung Normal Normal Tissue 26 58 Malignant Adenocarcinoma 15Squamous Cell Carcinoma 17 Lymph Normal Normal Tissue 4 23 NodeMalignant Hodgkin's Disease 4 Malignant Lymphoma 15 Ovary Normal NormalTissue 10 50 Malignant Adenocarcinoma 5 Clear Cell Adenocarcinoma 6Mucinous Cystadenocarcinoma 5 Serous Cystadenocarcinoma 6 PapillarySerous Adenocarcinoma 18 Pancreas Normal Normal Tissue 13 41 MalignantAdenocarcinoma 28 Prostate Normal Normal Tissue 14 41 MalignantAdenocarcinoma 27 Rectum Normal Normal Tissue 17 38 MalignantAdenocarcinoma 21 Stomach Normal Normal Tissue 17 60 MalignantAdenocarcinoma 37 Signet Ring Cell Carcinoma 6 Total 567

1. A method for quantifying an expression level of a target gene,comprising: 1) synthesizing cDNA from RNA of a subject; 2) performingreal time PCR to amplify the target gene using a pair of primers and/orprobes with the cDNA serving as a template and then performing real-timePCR to amplify an endogenous reference gene CUL1, wherein saidendogenous reference gene CUL1 is selected by a method comprising (a)computing expression levels of genes from EST (expressed sequence tag),SAGE (serial analysis of gene expression), and microarray datasets; and(b) identifying constitutively expressed genes from more than one tissuetype based on the computed gene expression level of step (a) and zero(0)'s proportions thereof; and 3) normalizing an expression level of thetarget gene to that of the endogenous reference gene CUL1 of step 2) 2.A method for quantifying an expression level of a target gene,comprising: 1) synthesizing cDNA from RNA of a subject; 2) performingreal time PCR to amplify the target gene using a pair of primers and/orprobes with the cDNA serving as a template and then performing real-timePCR to amplify an endogenous reference gene CUL1, wherein saidendogenous reference gene CUL1 is selected by a method comprising (a)computing expression levels of genes from EST (expressed sequence tag),SAGE (serial analysis of gene expression), and microarray datasets; and(b) identifying constitutively expressed genes from more than one tissuetype based on the computed gene expression level of step (a) and zero(0)'s proportions thereof; (c) determining the coefficient of variation(CV) for the endogenous reference gene; and (d) ranking the endogenousgene in an ascending order of CV; and 3) normalizing an expression levelof the target gene to that of the endogenous reference gene CUL1 of step2)